Search Results - "Luk, Kelvin C"

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration by Tran, Hien T., Chung, Charlotte Hiu-Yan, Iba, Michiyo, Zhang, Bin, Trojanowski, John Q., Luk, Kelvin C., Lee, Virginia M.Y.

“…Accumulation of misfolded alpha-synuclein (α-syn) into Lewy bodies (LBs) and Lewy neurites (LNs) is a major hallmark of Parkinson’s disease (PD) and dementia…”
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Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism by Osterberg, Valerie R., Spinelli, Kateri J., Weston, Leah J., Luk, Kelvin C., Woltjer, Randall L., Unni, Vivek K.

“…Aggregated alpha-synuclein inclusions are found where cell death occurs in several diseases, including Parkinson’s disease, dementia with Lewy bodies, and…”
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A growth-factor-activated lysosomal K+ channel regulates Parkinson’s pathology by Wie, Jinhong, Liu, Zhenjiang, Song, Haikun, Tropea, Thomas F., Yang, Lu, Wang, Huanhuan, Liang, Yuling, Cang, Chunlei, Aranda, Kimberly, Lohmann, Joey, Yang, Jing, Lu, Boxun, Chen-Plotkin, Alice S., Luk, Kelvin C., Ren, Dejian

“…Lysosomes have fundamental physiological roles and have previously been implicated in Parkinson’s disease 1 – 5 . However, how extracellular growth factors…”
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Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology by Manfredsson, Fredric P., Luk, Kelvin C., Benskey, Matthew J., Gezer, Aysegul, Garcia, Joanna, Kuhn, Nathan C., Sandoval, Ivette M., Patterson, Joseph R., O'Mara, Alana, Yonkers, Reid, Kordower, Jeffrey H.

“…Alpha-Synuclein (α-syn) is by far the most highly vetted pathogenic and therapeutic target in Parkinson's disease. Aggregated α-syn is present in sporadic…”
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Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death by Volpicelli-Daley, Laura A., Luk, Kelvin C., Patel, Tapan P., Tanik, Selcuk A., Riddle, Dawn M., Stieber, Anna, Meaney, David F., Trojanowski, John Q., Lee, Virginia M.-Y.

“…Inclusions composed of α-synuclein (α-syn), i.e., Lewy bodies (LBs) and Lewy neurites (LNs), define synucleinopathies including Parkinson's disease (PD) and…”
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Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau by Darwich, Nabil F, Phan, Jessica M, Kim, Boram, Suh, EunRan, Papatriantafyllou, John D, Changolkar, Lakshmi, Nguyen, Aivi T, O'Rourke, Caroline M, He, Zhuohao, Porta, Sílvia, Gibbons, Garrett S, Luk, Kelvin C, Papageorgiou, Sokratis G, Grossman, Murray, Massimo, Lauren, Irwin, David J, McMillan, Corey T, Nasrallah, Ilya M, Toro, Camilo, Aguirre, Geoffrey K, Van Deerlin, Vivianna M, Lee, Edward B

“…Neurodegeneration in Alzheimer's disease (AD) is closely associated with the accumulation of pathologic tau aggregates in the form of neurofibrillary tangles…”
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Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells by Luk, Kelvin C, Song, Cheng, O'Brien, Patrick, Stieber, Anna, Branch, Jonathan R, Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M.-Y

“…Cytoplasmic inclusions containing α-synuclein (α-Syn) fibrils, referred to as Lewy bodies (LBs), are the signature neuropathological hallmarks of Parkinson's…”
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Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration by Paumier, Katrina L, Luk, Kelvin C, Manfredsson, Fredric P, Kanaan, Nicholas M, Lipton, Jack W, Collier, Timothy J, Steece-Collier, Kathy, Kemp, Christopher J, Celano, Stephanie, Schulz, Emily, Sandoval, Ivette M, Fleming, Sheila, Dirr, Elliott, Polinski, Nicole K, Trojanowski, John Q, Lee, Virginia M, Sortwell, Caryl E

“…Abstract Previous studies demonstrate that intrastriatal injections of fibrillar alpha-synuclein (α-syn) into mice induce Parkinson's disease (PD)-like Lewy…”
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Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo by Wu, Qihui, Shaikh, Muhammad A., Meymand, Emily S., Zhang, Bin, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M.-Y.

“…Alpha-synuclein (αSyn) preformed fibrils (PFF) induce endogenous αSyn aggregation leading to reduced synaptic transmission. Neuronal activity modulates release…”
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Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages by Haenseler, Walther, Zambon, Federico, Lee, Heyne, Vowles, Jane, Rinaldi, Federica, Duggal, Galbha, Houlden, Henry, Gwinn, Katrina, Wray, Selina, Luk, Kelvin C., Wade-Martins, Richard, James, William S., Cowley, Sally A.

“…To examine the pathogenic role of α-synuclein (αS) in Parkinson’s Disease, we have generated induced Pluripotent Stem Cell lines from early onset Parkinson’s…”
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Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration by Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Luk, Kelvin C, Tansey, Malú G, Paumier, Katrina L, Kanaan, Nicholas M, Fischer, D Luke, Polinski, Nicole K, Barth, Olivia L, Howe, Jacob W, Vaikath, Nishant N, Majbour, Nour K, El-Agnaf, Omar M A, Sortwell, Caryl E

“…Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a platform to…”
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Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils by Patterson, Joseph R., Duffy, Megan F., Kemp, Christopher J., Howe, Jacob W., Collier, Timothy J., Stoll, Anna C., Miller, Kathryn M., Patel, Pooja, Levine, Nathan, Moore, Darren J., Luk, Kelvin C., Fleming, Sheila M., Kanaan, Nicholas M., Paumier, Katrina L., El-Agnaf, Omar M.A., Sortwell, Caryl E.

“…Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn) inclusions, progressive neurodegeneration of the nigrostriatal system…”
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Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity by Luk, Kelvin C., Covell, Dustin J., Kehm, Victoria M., Zhang, Bin, Song, Insung Y., Byrne, Matthew D., Pitkin, Rose M., Decker, Samantha C., Trojanowski, John Q., Lee, Virginia M.-Y.

“…The accumulation and propagation of misfolded α-synuclein (α-Syn) is a central feature of Parkinson’s disease and other synucleinopathies. Molecular…”
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α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice by Uemura, Norihito, Marotta, Nicholas P., Ara, Jahan, Meymand, Emily S., Zhang, Bin, Kameda, Hiroshi, Koike, Masato, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M.-Y.

“…Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been widely described yet templated fibrillization of LB-αSyn often fails…”
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Modeling Lewy pathology propagation in Parkinson's disease by Luk, Kelvin C, Lee, Virginia M.-Y

“…Summary Lewy bodies (LBs) and Lewy neurites (LNs), comprised of alpha-synuclein (aSyn), are intraneuronal inclusions that characterize Parkinson's disease…”
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Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice by Johnson, Michaela E., Bergkvist, Liza, Stetzik, Lucas, Steiner, Jennifer A., Meyerdirk, Lindsay, Schulz, Emily, Wolfrum, Emily, Luk, Kelvin C., Wesson, Daniel W., Krainc, Dimitri, Brundin, Patrik

“…Autophagic dysregulation and lysosomal impairment have been implicated in the pathogenesis of Parkinson's disease, partly due to the identification of…”
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TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson’s Disease by Zhu, Guixin, Harischandra, Dilshan S., Ghaisas, Shivani, Zhang, Pengfei, Prall, Wil, Huang, Liangqian, Maghames, Chantal, Guo, Lili, Luna, Esteban, Mack, Korrie L., Torrente, Mariana P., Luk, Kelvin C., Shorter, James, Yang, Xiaolu

“…Neurodegenerative diseases are characterized by the formation and propagation of protein aggregates, especially amyloid fibrils. However, what normally…”
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Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions by Stoll, Anna C., Kemp, Christopher J., Patterson, Joseph R., Howe, Jacob W., Steece-Collier, Kathy, Luk, Kelvin C., Sortwell, Caryl E., Benskey, Matthew J.

“…Parkinson's disease (PD) pathology is characterized by alpha-synuclein (α-syn) aggregates, degeneration of dopamine neurons in the substantia nigra pars…”
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A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes by Bhatia, Tarun N., Jamenis, Anuj S., Abbas, Muslim, Clark, Rachel N., Miner, Kristin M., Chandwani, Manisha N., Kim, Roxanne E., Hilinski, William, O'Donnell, Lauren A., Luk, Kelvin C., Shi, Yejie, Hu, Xiaoming, Chen, Jun, Brodsky, Jeffrey L., Leak, Rehana K.

“…Reactive microglia are observed with aging and in Lewy body disorders, including within the olfactory bulb of men with Parkinson's disease. However, the…”
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Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition by Stoll, Anna C, Kemp, Christopher J, Patterson, Joseph R, Kubik, Michael, Kuhn, Nathan, Benskey, Matthew, Duffy, Megan F, Luk, Kelvin C, Sortwell, Caryl E

“…Parkinson's disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy…”
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