Search Results - "Luk, Ian"

ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer by Luk, Ian Y, Reehorst, Camilla M, Mariadason, John M

“…The epithelium-specific ETS (ESE) transcription factors (ELF3, ELF5, EHF and SPDEF) are defined by their highly conserved ETS DNA binding domain and…”
Get full text

Dual targeting of FGFR3 and ERBB3 enhances the efficacy of FGFR inhibitors in FGFR3 fusion-driven bladder cancer by Weickhardt, Andrew J, Lau, David K, Hodgson-Garms, Margeaux, Lavis, Austen, Jenkins, Laura J, Vukelic, Natalia, Ioannidis, Paul, Luk, Ian Y, Mariadason, John M

“…Mutations and fusions in Fibroblast Growth Factor Receptor 3 (FGFR3) occur in 10-20% of metastatic urothelial carcinomas and confer sensitivity to FGFR…”
Get full text

EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc -initiated colonic tumorigenesis by Reehorst, Camilla M., Nightingale, Rebecca, Luk, Ian Y., Jenkins, Laura, Koentgen, Frank, Williams, David S., Darido, Charbel, Tan, Fiona, Anderton, Holly, Chopin, Michael, Schoffer, Kael, Eissmann, Moritz F., Buchert, Michael, Mouradov, Dmitri, Sieber, Oliver M., Ernst, Matthias, Dhillon, Amardeep S., Mariadason, John M.

“…ABSTRACT Ets homologous factor (EHF) is a member of the epithelial-specific Ets (ESE) family of transcription factors. To investigate its role in development…”
Get full text

Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis by Nightingale, Rebecca, Reehorst, Camilla M, Vukelic, Natalia, Papadopoulos, Nikolaos, Liao, Yang, Guleria, Shalini, Bell, Caroline, Vaillant, François, Paul, Sudip, Luk, Ian Y, Dhillon, Amardeep S, Jenkins, Laura J, Morrow, Riley J, Jackling, Felicity C, Chand, Ashwini L, Chisanga, David, Chen, Yunshun, Williams, David S, Anderson, Robin L, Ellis, Sarah, Meikle, Peter J, Shi, Wei, Visvader, Jane E, Pal, Bhupinder, Mariadason, John M

“…The transcription factor EHF is highly expressed in the lactating mammary gland, but its role in mammary development and tumorigenesis is not fully understood…”
Get more information

Rapid Resistance of FGFR-driven Gastric Cancers to Regorafenib and Targeted FGFR Inhibitors can be Overcome by Parallel Inhibition of MEK by Lau, David K, Luk, Ian Y, Jenkins, Laura J, Martin, Andrew, Williams, David S, Schoffer, Kael L, Chionh, Fiona, Buchert, Michael, Sjoquist, Katrin, Boussioutas, Alex, Hayes, Sarah A, Ernst, Matthias, Weickhardt, Andrew J, Pavlakis, Nick, Tebbutt, Niall C, Mariadason, John M

“…Amplification or overexpression of the FGFR family of receptor tyrosine kinases occurs in a significant proportion of gastric cancers. Regorafenib is a…”
Get full text

Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death by Jenkins, Laura J, Luk, Ian Y, Fairlie, W Douglas, Lee, Erinna F, Palmieri, Michelle, Schoffer, Kael L, Tan, Tao, Ng, Irvin, Vukelic, Natalia, Tran, Sharon, Tse, Janson W T, Nightingale, Rebecca, Alam, Zakia, Chionh, Fiona, Iatropoulos, George, Ernst, Matthias, Afshar-Sterle, Shoukat, Desai, Jayesh, Gibbs, Peter, Sieber, Oliver M, Dhillon, Amardeep S, Tebbutt, Niall C, Mariadason, John M

“…The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyperactivated in most colorectal cancers. A current limitation of inhibitors of this pathway is that they…”
Get full text

ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types by Chüeh, Anderly C., Tse, Janson W.T., Dickinson, Michael, Ioannidis, Paul, Jenkins, Laura, Togel, Lars, Tan, BeeShin, Luk, Ian, Davalos-Salas, Mercedes, Nightingale, Rebecca, Thompson, Matthew R., Williams, Bryan R.G., Lessene, Guillaume, Lee, Erinna F., Fairlie, Walter D., Dhillon, Amardeep S., Mariadason, John M.

“…Abstract Purpose: Histone deacetylase inhibitors (HDACi) are epigenome-targeting small molecules approved for the treatment of cutaneous T-cell lymphoma and…”
Get full text

Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression by Luk, Ian Y., Jenkins, Laura J., Schoffer, Kael L., Ng, Irvin, Tse, Janson W. T., Mouradov, Dmitri, Kaczmarczyk, Stanislaw, Nightingale, Rebecca, Burrows, Allan D., Anderson, Robin L., Arango, Diego, Dopeso, Higinio, Croft, Larry, Richardson, Mark F., Sieber, Oliver M., Liao, Yang, Mooi, Jennifer K., Vukelic, Natalia, Reehorst, Camilla M., Afshar-Sterle, Shoukat, Whitehall, Vicki L. J., Fennell, Lochlan, Abud, Helen E., Tebbutt, Niall C., Phillips, Wayne A., Williams, David S., Shi, Wei, Mielke, Lisa A., Ernst, Matthias, Dhillon, Amardeep S., Clemons, Nicholas J., Mariadason, John M.

“…Colorectal cancers (CRCs) often display histological features indicative of aberrant differentiation but the molecular underpinnings of this trait and whether…”
Get full text

Cell Line Models of Molecular Subtypes of Colorectal Cancer by Mooi, Jennifer K, Luk, Ian Y, Mariadason, John M

“…Colorectal cancer (CRC) is a genetically diverse disease necessitating the need for well-characterized and reproducible models to enable its accurate…”
Get more information

BCL-XL inhibitors enhance the apoptotic efficacy of BRAF inhibitors in BRAFV600E colorectal cancer by Jenkins, Laura J., Luk, Ian Y., Chionh, Fiona, Tan, Tao, Needham, Kristen, Ayton, Jamieson, Reehorst, Camilla M., Vukelic, Natalia, Sieber, Oliver M., Mouradov, Dmitri, Gibbs, Peter, Williams, David S., Tebbutt, Niall C., Desai, Jayesh, Hollande, Frédéric, Dhillon, Amardeep S., Lee, Erinna F., Merino, Delphine, Fairlie, W. Douglas, Mariadason, John M.

“…Metastatic BRAF V600E colorectal cancer (CRC) carries an extremely poor prognosis and is in urgent need of effective new treatments. While the BRAF V600E…”
Get full text

Author Correction: DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis by Tögel, Lars, Nightingale, Rebecca, Wu, Rui, Chüeh, Anderly C., Al-Obaidi, Sheren, Luk, Ian, Dávalos-Salas, Mercedes, Chionh, Fiona, Murone, Carmel, Buchanan, Daniel D., Chatterton, Zac, Sieber, Oliver M., Arango, Diego, Tebbutt, Niall C., Williams, David, Dhillon, Amardeep S., Mariadason, John M.

Get full text

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis by Tögel, Lars, Nightingale, Rebecca, Wu, Rui, Chüeh, Anderly C., Al-Obaidi, Sheren, Luk, Ian, Dávalos-Salas, Mercedes, Chionh, Fiona, Murone, Carmel, Buchanan, Daniel D., Chatterton, Zac, Sieber, Oliver M., Arango, Diego, Tebbutt, Niall C., Williams, David, Dhillon, Amardeep S., Mariadason, John M.

“…The ERK signalling pathway regulates key cell fate decisions in the intestinal epithelium and is frequently dysregulated in colorectal cancers (CRCs)…”
Get full text

BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking by Tran, Sharon, Juliani, Juliani, Harris, Tiffany J., Evangelista, Marco, Ratcliffe, Julian, Ellis, Sarah L., Baloyan, David, Reehorst, Camilla M., Nightingale, Rebecca, Luk, Ian Y., Jenkins, Laura J., Ghilas, Sonia, Yakou, Marina H., Inguanti, Chantelle, Johnson, Chad, Buchert, Michael, Lee, James C., De Cruz, Peter, Duszyc, Kinga, Gleeson, Paul A., Kile, Benjamin T., Mielke, Lisa A., Yap, Alpha S., Mariadason, John M., Fairlie, W. Douglas, Lee, Erinna F.

“…Autophagy-related genes have been closely associated with intestinal homeostasis. BECLIN1 is a component of Class III phosphatidylinositol 3-kinase complexes…”
Get full text

Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets by Lau, David K., Mouradov, Dmitri, Wasenang, Wiphawan, Luk, Ian Y., Scott, Cameron M., Williams, David S., Yeung, Yvonne H., Limpaiboon, Temduang, Iatropoulos, George F., Jenkins, Laura J., Reehorst, Camilla M., Chionh, Fiona, Nikfarjam, Mehrdad, Croagh, Daniel, Dhillon, Amardeep S., Weickhardt, Andrew J., Muramatsu, Toshihide, Saito, Yoshimasa, Tebbutt, Niall C., Sieber, Oliver M., Mariadason, John M.

“…Biliary tract cancers (BTCs) currently have no approved targeted therapies. Although genomic profiling of primary BTCs has identified multiple potential drug…”
Get full text

IL-36G promotes cancer-cell intrinsic hallmarks in human gastric cancer cells by Le, Ngan, Luk, Ian, Chisanga, David, Shi, Wei, Pang, Lokman, Scholz, Glen, Mariadason, John, Ernst, Matthias, Huynh, Jennifer

“…•Cytokines are key molecular drivers of neoplastic transformation and metastatic spread.•IL-36G confer a pro-tumorigenic effect on human gastric cancer cell…”
Get full text

Abstract 1995: DUSP4 loss enhances resistance to encorafenib plus cetuximab in BRAF mutant colorectal cancer by Needham, Kristen, Chionh, Fiona, Kaczmarczyk, Stan, Kearney, Connor, Jenkins, Laura, Luk, Ian, Mariadason, John M.

“…Abstract The 5-year survival rate for metastatic colorectal cancer (CRC) is less than 14%. Hyperactivation of the ERK/MAPK pathway occurs at a high frequency…”
Get full text

Correction: ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors Across Tumor Types by Chüeh, Anderly C., Tse, Janson W.T., Dickinson, Michael, Ioannidis, Paul, Jenkins, Laura, Togel, Lars, Tan, BeeShin, Luk, Ian, Davalos-Salas, Mercedes, Nightingale, Rebecca, Thompson, Matthew R., Williams, Bryan R.G., Lessene, Guillaume, Lee, Erinna F., Fairlie, Walter D., Dhillon, Amardeep S., Mariadason, John M.

Get full text

Abstract 2492: BRAF inhibitors synergize with BH3 mimetics to induce apoptosis in BRAF mutant colorectal cancer cells by Jenkins, Laura J., Chionh, Fiona, Luk, Ian Y., Lee, Erinna F., Dhillon, Amardeep S., Tebbutt, Niall, Fairlie, Walter D., Mariadason, John M.

“…Abstract Activating mutations in BRAF (BRAFV600E) occur in ~10% of colorectal cancers (CRCs) and drive tumorigenesis through constitutive activation of MAPK…”
Get full text

CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation by Chüeh, Anderly C., Advani, Gahana, Foroutan, Momeneh, Smith, Jai, Ng, Nadia, Nandurkar, Harshal, Lio, Daisy S., Zhu, Hong-Jian, Chong, Yuh-Ping, Verkade, Heather, Fujita, Donald J., Bjorge, Jeffrey, Basheer, Faiza, Lim, Jet Phey, Luk, Ian, Dhillon, Amardeep, Sakthianandeswaren, Anuratha, Mouradov, Dmitri, Sieber, Oliver, Hollande, Frédéric, Mariadason, John M., Cheng, Heung-Chin

“…Hyperactivation of SRC-family protein kinases (SFKs) contributes to the initiation and progression of human colorectal cancer (CRC). Since oncogenic mutations…”
Get full text

Abstract 3529: Investigating the in vivo role of the EHF transcription factor in intestinal epithelial differentiation by Reehorst, Camilla M., Luk, Ian Y., Nightingale, Rebecca, Davalos-Salas, Mercedes, Dhillon, Amardeep S., Mariadason, John M.

“…Abstract Objective: Poor tumor differentiation status is associated with worse patient outcome in colorectal cancer. However, the molecular basis for loss of…”
Get full text