Search Results - "Luisier, Raphaelle"

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS by Luisier, Raphaelle, Tyzack, Giulia E., Hall, Claire E., Mitchell, Jamie S., Devine, Helen, Taha, Doaa M., Malik, Bilal, Meyer, Ione, Greensmith, Linda, Newcombe, Jia, Ule, Jernej, Luscombe, Nicholas M., Patani, Rickie

“…Mutations causing amyotrophic lateral sclerosis (ALS) strongly implicate ubiquitously expressed regulators of RNA processing. To understand the molecular…”
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Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis by Tyzack, Giulia E, Luisier, Raphaelle, Taha, Doaa M, Neeves, Jacob, Modic, Miha, Mitchell, Jamie S, Meyer, Ione, Greensmith, Linda, Newcombe, Jia, Ule, Jernej, Luscombe, Nicholas M, Patani, Rickie

“…Mutations causing amyotrophic lateral sclerosis (ALS) clearly implicate ubiquitously expressed and predominantly nuclear RNA binding proteins, which form…”
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Mammary epithelial morphogenesis in 3D combinatorial microenvironments by Luisier, Raphaelle, Girgin, Mehmet, Lutolf, Matthias P., Ranga, Adrian

“…Human mammary epithelial cells can proliferate and reorganize into polarized multi-cellular constructs in-vitro, thereby functioning as an important model…”
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Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis by Tyzack, Giulia E, Neeves, Jacob, Crerar, Hamish, Klein, Pierre, Ziff, Oliver, Taha, Doaa M, Luisier, Raphaëlle, Luscombe, Nicholas M, Patani, Rickie

“…Abstract We recently described aberrantly increased cytoplasmic SFPQ intron-retaining transcripts (IRTs) and concurrent SFPQ protein mislocalization as new…”
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Cytoplasmic cleavage of IMPA1 3′ UTR is necessary for maintaining axon integrity by Andreassi, Catia, Luisier, Raphaëlle, Crerar, Hamish, Darsinou, Marousa, Blokzijl-Franke, Sasja, Lenn, Tchern, Luscombe, Nicholas M., Cuda, Giovanni, Gaspari, Marco, Saiardi, Adolfo, Riccio, Antonella

“…The 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are non-coding sequences involved in many aspects of mRNA metabolism, including intracellular…”
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Editorial: RNA at a breaking point? Cytoplasmic cleavage and other post-transcriptional RNA processing in neurodevelopment and disease by Piwecka, Monika, Luisier, Raphaelle, Andreassi, Catia

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Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis by Petrić Howe, Marija, Crerar, Hamish, Neeves, Jacob, Harley, Jasmine, Tyzack, Giulia E, Klein, Pierre, Ramos, Andres, Patani, Rickie, Luisier, Raphaëlle

“…Intron retention (IR) is now recognized as a dominant splicing event during motor neuron (MN) development; however, the role and regulation of intron-retaining…”
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Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology by Ziff, Oliver J., Neeves, Jacob, Mitchell, Jamie, Tyzack, Giulia, Martinez-Ruiz, Carlos, Luisier, Raphaelle, Chakrabarti, Anob M., McGranahan, Nicholas, Litchfield, Kevin, Boulton, Simon J., Al-Chalabi, Ammar, Kelly, Gavin, Humphrey, Jack, Patani, Rickie

“…Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97% of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been…”
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Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS by Hall, Claire E., Yao, Zhi, Choi, Minee, Tyzack, Giulia E., Serio, Andrea, Luisier, Raphaelle, Harley, Jasmine, Preza, Elisavet, Arber, Charlie, Crisp, Sarah J., Watson, P. Marc D., Kullmann, Dimitri M., Abramov, Andrey Y., Wray, Selina, Burley, Russell, Loh, Samantha H.Y., Martins, L. Miguel, Stevens, Molly M., Luscombe, Nicholas M., Sibley, Christopher R., Lakatos, Andras, Ule, Jernej, Gandhi, Sonia, Patani, Rickie

“…Motor neurons (MNs) and astrocytes (ACs) are implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but their interaction and the sequence of…”
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Ha‐ras and β‐catenin oncoproteins orchestrate metabolic programs in mouse liver tumors by Unterberger, Elif B., Eichner, Johannes, Wrzodek, Clemens, Lempiäinen, Harri, Luisier, Raphaëlle, Terranova, Rémi, Metzger, Ute, Plummer, Simon, Knorpp, Thomas, Braeuning, Albert, Moggs, Jonathan, Templin, Markus F., Honndorf, Valerie, Piotto, Martial, Zell, Andreas, Schwarz, Michael

“…The process of hepatocarcinogenesis in the diethylnitrosamine (DEN) initiation/phenobarbital (PB) promotion mouse model involves the selective clonal outgrowth…”
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The predicted RNA-binding protein regulome of axonal mRNAs by Luisier, Raphaëlle, Andreassi, Catia, Fournier, Lisa, Riccio, Antonella

“…Neurons are morphologically complex cells that rely on the compartmentalization of protein expression to develop and maintain their cytoarchitecture. The…”
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m6a methylation orchestrates IMP1 regulation of microtubules during human neuronal differentiation by Klein, Pierre, Petrić Howe, Marija, Harley, Jasmine, Crook, Harry, Esteban Serna, Sofia, Roumeliotis, Theodoros I., Choudhary, Jyoti S., Chakrabarti, Anob M., Luisier, Raphaëlle, Patani, Rickie, Ramos, Andres

“…Neuronal differentiation requires building a complex intracellular architecture, and therefore the coordinated regulation of defined sets of genes. RNA-binding…”
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c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells by Gabryšová, Leona, Alvarez-Martinez, Marisol, Luisier, Raphaëlle, Cox, Luke S., Sodenkamp, Jan, Hosking, Caroline, Pérez-Mazliah, Damián, Whicher, Charlotte, Kannan, Yashaswini, Potempa, Krzysztof, Wu, Xuemei, Bhaw, Leena, Wende, Hagen, Sieweke, Michael H., Elgar, Greg, Wilson, Mark, Briscoe, James, Metzis, Vicki, Langhorne, Jean, Luscombe, Nicholas M., O’Garra, Anne

“…The transcription factor c-Maf induces the anti-inflammatory cytokine IL-10 in CD4 + T cells in vitro. However, the global effects of c-Maf on diverse immune…”
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Automated and unbiased discrimination of ALS from control tissue at single cell resolution by Hagemann, Cathleen, Tyzack, Giulia E., Taha, Doaa M., Devine, Helen, Greensmith, Linda, Newcombe, Jia, Patani, Rickie, Serio, Andrea, Luisier, Raphaëlle

“…Histopathological analysis of tissue sections is invaluable in neurodegeneration research. However, cell‐to‐cell variation in both the presence and severity of…”
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Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion by Lempiäinen, Harri, Couttet, Philippe, Bolognani, Federico, Müller, Arne, Dubost, Valérie, Luisier, Raphaëlle, Del Rio Espinola, Alberto, Vitry, Veronique, Unterberger, Elif B, Thomson, John P, Treindl, Fridolin, Metzger, Ute, Wrzodek, Clemens, Hahne, Florian, Zollinger, Tulipan, Brasa, Sarah, Kalteis, Magdalena, Marcellin, Magali, Giudicelli, Fanny, Braeuning, Albert, Morawiec, Laurent, Zamurovic, Natasa, Längle, Ulrich, Scheer, Nico, Schübeler, Dirk, Goodman, Jay, Chibout, Salah-Dine, Marlowe, Jennifer, Theil, Diethilde, Heard, David J, Grenet, Olivier, Zell, Andreas, Templin, Markus F, Meehan, Richard R, Wolf, Roland C, Elcombe, Clifford R, Schwarz, Michael, Moulin, Pierre, Terranova, Rémi, Moggs, Jonathan G

“…The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of…”
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Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors by Luisier, Raphaëlle, Lempiäinen, Harri, Scherbichler, Nina, Braeuning, Albert, Geissler, Miriam, Dubost, Valerie, Müller, Arne, Scheer, Nico, Chibout, Salah-Dine, Hara, Hisanori, Picard, Frank, Theil, Diethilde, Couttet, Philippe, Vitobello, Antonio, Grenet, Olivier, Grasl-Kraupp, Bettina, Ellinger-Ziegelbauer, Heidrun, Thomson, John P, Meehan, Richard R, Elcombe, Clifford R, Henderson, Colin J, Wolf, C Roland, Schwarz, Michael, Moulin, Pierre, Terranova, Rémi, Moggs, Jonathan G

“…The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play…”
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Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion by Luisier, Raphaëlle, Unterberger, Elif B, Goodman, Jay I, Schwarz, Michael, Moggs, Jonathan, Terranova, Rémi, van Nimwegen, Erik

“…Gene regulatory interactions underlying the early stages of non-genotoxic carcinogenesis are poorly understood. Here, we have identified key candidate…”
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Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells by Gabryšová, Leona, Alvarez-Martinez, Marisol, Luisier, Raphaëlle, Cox, Luke S., Sodenkamp, Jan, Hosking, Caroline, Pérez-Mazliah, Damián, Whicher, Charlotte, Kannan, Yashaswini, Potempa, Krzysztof, Wu, Xuemei, Bhaw, Leena, Wende, Hagen, Sieweke, Michael H., Elgar, Greg, Wilson, Mark, Briscoe, James, Metzis, Vicki, Langhorne, Jean, Luscombe, Nicholas M., O’Garra, Anne

“…In the version of this article initially published, the Supplementary Data file was an incorrect version. The correct version is now provided. The error has…”
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NOA 63 as a UV-curable material for fabrication of microfluidic channels with native hydrophilicity by Dupont, Emile P., Luisier, Raphaëlle, Gijs, Martin A.M.

“…In this paper, we propose a method to create a natively hydrophilic microfluidic structure in a fast and simple way using an UV-curable polymer (NOA 63 from…”
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Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS by Tyzack, Giulia E, Manferrari, Giulia, Newcombe, Jia, Luscombe, Nicholas M, Luisier, Raphaelle, Patani, Rickie

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