Search Results - "Luisa Laorden, M."

Hypothalamic orexin--a neurons are involved in the response of the brain stress system to morphine withdrawal by Laorden, M Luisa, Ferenczi, Szilamér, Pintér-Kübler, Bernadett, González-Martín, Laura L, Lasheras, M Carmen, Kovács, Krisztina J, Milanés, M Victoria, Núñez, Cristina

“…Both the hypothalamus-pituitary-adrenal (HPA) axis and the extrahypothalamic brain stress system are key elements of the neural circuitry that regulates the…”
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Maternal Separation Impairs Cocaine-Induced Behavioural Sensitization in Adolescent Mice by Gracia-Rubio, Irene, Martinez-Laorden, Elena, Moscoso-Castro, Maria, Milanés, M Victoria, Laorden, M Luisa, Valverde, Olga

“…Adverse early-life conditions induce persistent disturbances that give rise to negative emotional states. Therefore, early life stress confers increased…”
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Glucocorticoid Homeostasis in the Dentate Gyrus Is Essential for Opiate Withdrawal-Associated Memories by García-Pérez, Daniel, Ferenczi, Szilamer, Kovács, Krisztina J., Laorden, M. Luisa, Milanés, M. Victoria, Núñez, Cristina

“…Drug-withdrawal-associated aversive memories might trigger relapse to drug-seeking behavior. However, changes in structural and synaptic plasticity, as well as…”
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Different contribution of glucocorticoids in the basolateral amygdala to the formation and expression of opiate withdrawal-associated memories by García-Pérez, Daniel, Ferenczi, Szilamer, Kovács, Krisztina J, Laorden, M. Luisa, Milanés, M. Victoria, Núñez, Cristina

“…Highlights • ADX morphine dependent rats do not exhibit naloxone-induced conditioned place aversion. • However, adrenalectomy increases the somatic expression…”
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Corticotropin-releasing factor 1 receptor mediates the activity of the reward system evoked by morphine-induced conditioned place preference by Lasheras, M. Carmen, Laorden, M. Luisa, Milanés, M. Victoria, Núñez, Cristina

“…Different neurotransmitter systems are involved in behavioural and molecular responses to morphine. The brain stress system is activated by acute…”
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Modulation of stress- and cocaine prime-induced reinstatement of conditioned place preference after memory extinction through dopamine D3 receptor by Guerrero-Bautista, Rocío, Do Couto, Bruno Ribeiro, Hidalgo, Juana M., Cárceles-Moreno, Francisco José, Molina, Guillermo, Laorden, M. Luisa, Núñez, Cristina, Milanés, M. Victoria

“…Accumulating evidence indicates that dopamine (DA) D3 receptor (DAD3R) antagonists appear highly promising in attenuating cocaine reward and relapse in…”
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Acute Morphine, Chronic Morphine, and Morphine Withdrawal Differently Affect Pleiotrophin, Midkine, and Receptor Protein Tyrosine Phosphatase β/ζ Regulation in the Ventral Tegmental Area by García-Pérez, Daniel, Laorden, M. Luisa, Milanés, M. Victoria

“…Pleiotrophin (PTN) and midkine (MK) are secreted growth factors and cytokines, proposed to be significant neuromodulators with multiple neuronal functions. PTN…”
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Glucocorticoids regulation of FosB/ΔFosB expression induced by chronic opiate exposure in the brain stress system by García-Pérez, Daniel, Laorden, M Luisa, Milanés, M Victoria, Núñez, Cristina

“…Chronic use of drugs of abuse profoundly alters stress-responsive system. Repeated exposure to morphine leads to accumulation of the transcription factor…”
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Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal by Navarro-Zaragoza, Javier, Núñez, Cristina, Laorden, M Luisa, Milanés, M Victoria

“…The role of stress in drug addiction is well established. The negative affective states of withdrawal most probably involve recruitment of brain stress…”
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Glucocorticoid receptor but not mineralocorticoid receptor mediates the activation of ERK pathway and CREB during morphine withdrawal by Navarro‐Zaragoza, Javier, Laorden, M. Luisa, Milanés, M. Victoria

“…Recent research suggests that glucocorticoids are involved in the development of addiction to drugs of abuse. They share this role with dopamine (DA), and with…”
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Glucocorticoid receptors participate in the opiate withdrawal‐induced stimulation of rats NTS noradrenergic activity and in the somatic signs of morphine withdrawal by Navarro‐Zaragoza, Javier, Hidalgo, Juana M, Laorden, M Luisa, Milanés, M Victoria

“…BACKGROUND AND PURPOSE Recent evidence suggests that glucocorticoid receptor (GR) is a major molecular substrate of addictive properties of drugs of abuse…”
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Regulation of dopaminergic markers expression in response to acute and chronic morphine and to morphine withdrawal by García-Pérez, Daniel, Núñez, Cristina, Laorden, M. Luisa, Milanés, M. Victoria

“…Dopamine (DA) is thought to represent a teaching signal and has been implicated in the induction of addictive behaviours. Dysfunction of DA homeostasis leading…”
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Spironolactone decreases the somatic signs of opiate withdrawal by blocking the mineralocorticoid receptors (MR) by Navarro-Zaragoza, Javier, Laorden, M.Luisa, Milanés, M.Victoria

“…Abstract Pharmacological evidence has accumulated showing that glucocorticoids and glucocorticoid receptor (GR) facilitate several responses to different drugs…”
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Restricted role of CRF1 receptor for the activity of brainstem catecholaminergic neurons in the negative state of morphine withdrawal by Garcia-Carmona, Juan-Antonio, Almela, Pilar, Baroja-Mazo, Alberto, Milanes, M. Victoria, Laorden, M. Luisa

“…Rationale Evidence suggests that corticotropin-releasing factor (CRF) system is an important mediator in the negative symptoms of opioid withdrawal. Objectives…”
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CRF2 mediates the increased noradrenergic activity in the hypothalamic paraventricular nucleus and the negative state of morphine withdrawal in rats by Navarro‐Zaragoza, Javier, Núñez, Cristina, Ruiz‐Medina, Jessica, Laorden, M Luisa, Valverde, Olga, Milanés, M Victoria

“…BACKGROUND AND PURPOSE Recent evidence suggests that corticotropin‐releasing factor (CRF) receptor signalling is involved in modulating the negative symptoms…”
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Accumbal dopamine, noradrenaline and serotonin activity after naloxone-conditioned place aversion in morphine-dependent mice by Gómez-Milanés, Iván, Almela, Pilar, García-Carmona, Juan-Antonio, Salud García-Gutiérrez, M., Aracil-Fernández, Auxiliadora, Manzanares, Jorge, Victoria Milanés Maquilón, M., Luisa Laorden, M.

“…► We evaluate the role of monoamines in naloxone-induced conditioned place aversion (CPA). ► We examined changes in the turnover of DA, NA and 5-HT in the…”
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Increased spinal dynorphin levels and phospho-extracellular signal-regulated kinases 1 and 2 and c-Fos immunoreactivity after surgery under remifentanil anesthesia in mice by Campillo, Ana, González-Cuello, Ana, Cabañero, David, Garcia-Nogales, Paula, Romero, Asunción, Milanés, M Victoria, Laorden, M Luisa, Puig, Margarita M

“…In humans, remifentanil anesthesia enhances nociceptive sensitization in the postoperative period. We hypothesized that activation of extracellular…”
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Involvement of noradrenergic transmission in the PVN on CREB activation, TORC1 levels, and pituitary-adrenal axis activity during morphine withdrawal by Martín, Fátima, Núñez, Cristina, Marín, M Teresa, Laorden, M Luisa, Kovács, Krisztina J, Milanés, M Victoria

“…Experimental and clinical findings have shown that administration of adrenoceptor antagonists alleviated different aspects of drug withdrawal and dependence…”
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Regulation of Serine (Ser)-31 and Ser40 Tyrosine Hydroxylase Phosphorylation during Morphine Withdrawal in the Hypothalamic Paraventricular Nucleus and Nucleus Tractus Solitarius-A2 Cell Group: Role of ERK1/2 by Núñez, Cristina, Laorden, M. Luisa, Milanés, M. Victoria

“…Our previous studies have shown that naloxone-induced morphine withdrawal increases the hypothalamic-pituitary-adrenocortical (HPA) axis activity, which is…”
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Elevated Glucocorticoid Levels Are Responsible for Induction of Tyrosine Hydroxylase mRNA Expression, Phosphorylation, and Enzyme Activity in the Nucleus of the Solitary Tract during Morphine Withdrawal by Núñez, Cristina, Földes, Anna, Pérez-Flores, Domingo, García-Borrón, J. Carlos, Laorden, M. Luisa, Kovács, Krisztina J, Milanés, M. Victoria

“…Chronic opiate exposure induces neurochemical adaptations in the noradrenergic system. Enhanced responsiveness of the hypothalamo-pituitary-adrenal axis after…”
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