Search Results - "Luinenburg, Mark"

Epileptogenesis in tuberous sclerosis complex-related developmental and epileptic encephalopathy by Aronica, Eleonora, Specchio, Nicola, Luinenburg, Mark J, Curatolo, Paolo

“…Abstract Epileptogenesis in infants with tuberous sclerosis complex (TSC) is a gradual and dynamic process, leading to early onset and difficult-to-treat…”
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Identification of gene regulatory networks affected across drug-resistant epilepsies by François, Liesbeth, Romagnolo, Alessia, Luinenburg, Mark J., Anink, Jasper J., Godard, Patrice, Rajman, Marek, van Eyll, Jonathan, Mühlebner, Angelika, Skelton, Andrew, Mills, James D., Dedeurwaerdere, Stefanie, Aronica, Eleonora

“…Epilepsy is a chronic and heterogenous disease characterized by recurrent unprovoked seizures, that are commonly resistant to antiseizure medications. This…”
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Astroglial calcium signaling and homeostasis in tuberous sclerosis complex by Romagnolo, Alessia, Dematteis, Giulia, Scheper, Mirte, Luinenburg, Mark J., Mühlebner, Angelika, Van Hecke, Wim, Manfredi, Marcello, De Giorgis, Veronica, Reano, Simone, Filigheddu, Nicoletta, Bortolotto, Valeria, Tapella, Laura, Anink, Jasper J., François, Liesbeth, Dedeurwaerdere, Stefanie, Mills, James D., Genazzani, Armando A., Lim, Dmitry, Aronica, Eleonora

“…Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by the development of benign tumors in various organs, including the brain,…”
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Impaired myelin production due to an intrinsic failure of oligodendrocytes in mTORpathies by Gruber, Victoria‐Elisabeth, Lang, Judith, Endmayr, Verena, Diehm, Robert, Pimpel, Birgit, Glatter, Sarah, Anink, Jasper J., Bongaarts, Anika, Luinenburg, Mark J., Reinten, Roy J., Wel, Nicole, Larsen, Per, Hainfellner, Johannes A., Rössler, Karl, Aronica, Eleonora, Scholl, Theresa, Mühlebner, Angelika, Feucht, Martha

“…Aims We aim to evaluate if the myelin pathology observed in epilepsy‐associated focal cortical dysplasia type 2B (FCD2B) and—histologically…”
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Increased expression of complement components in tuberous sclerosis complex and focal cortical dysplasia type 2B brain lesions by Gruber, Victoria‐Elisabeth, Luinenburg, Mark J., Colleselli, Katrin, Endmayr, Verena, Anink, Jasper J., Zimmer, Till S., Jansen, Floor, Gosselaar, Peter, Coras, Roland, Scholl, Theresa, Blumcke, Ingmar, Pimentel, José, Hainfellner, Johannes A., Höftberger, Romana, Rössler, Karl, Feucht, Martha, Scheppingen, Jackelien, Aronica, Eleonora, Mühlebner, Angelika

“…Objective Increasing evidence supports the contribution of inflammatory mechanisms to the neurological manifestations of epileptogenic developmental…”
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Loss of maturity and homeostatic functions in Tuberous Sclerosis Complex-derived astrocytes by Luinenburg, Mark J, Scheper, Mirte, Sørensen, Frederik N F, Anink, Jasper J, Van Hecke, Wim, Korshunova, Irina, Jansen, Floor E, Riney, Kate, van Eijsden, Pieter, Gosselaar, Peter, Mills, James D, Kalf, Rozemarijn S, Zimmer, Till S, Broekaart, Diede W M, Khodosevich, Konstantin, Aronica, Eleonora, Mühlebner, Angelika

“…Constitutive activation of the mTOR pathway, as observed in Tuberous Sclerosis Complex (TSC), leads to glial dysfunction and subsequent epileptogenesis…”
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MicroRNA‐34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis by Korotkov, Anatoly, Sim, Nam Suk, Luinenburg, Mark J., Anink, Jasper J., Scheppingen, Jackelien, Zimmer, Till S., Bongaarts, Anika, Broekaart, Diede W. M., Mijnsbergen, Caroline, Jansen, Floor E., Van Hecke, Wim, Spliet, Wim G. M., Rijen, Peter C., Feucht, Martha, Hainfellner, Johannes A., Kršek, Pavel, Zamecnik, Josef, Crino, Peter B., Kotulska, Katarzyna, Lagae, Lieven, Jansen, Anna C., Kwiatkowski, David J., Jozwiak, Sergiusz, Curatolo, Paolo, Mühlebner, Angelika, Lee, Jeong H., Mills, James D., Vliet, Erwin A., Aronica, Eleonora

“…Aims Tuberous sclerosis complex (TSC) is a genetic disorder associated with dysregulation of the mechanistic target of rapamycin complex 1 (mTORC1) signalling…”
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Expression of Oncolytic Adenovirus-Encoded RNAi Molecules Is Most Effective in a pri-miRNA Precursor Format by Brachtlova, Tereza, van Ginkel, Jan-Willem, Luinenburg, Mark J., de Menezes, Renée X., Koppers-Lalic, Danijela, Pegtel, D. Michiel, Dong, Wenliang, de Gruijl, Tanja D., van Beusechem, Victor W.

“…Oncolytic adenoviruses are being developed as new anti-cancer agents. Their efficacy can be improved by incorporating RNA interference (RNAi) molecules. RNAi…”
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Genetic pathogenesis of the epileptogenic lesions in Tuberous Sclerosis Complex: Therapeutic targeting of the mTOR pathway by Moavero, Romina, Mühlebner, Angelika, Luinenburg, Mark Jasper, Craiu, Dana, Aronica, Eleonora, Curatolo, Paolo

“…•Overactivation of the mTOR pathway is responsible for TSC-related epilepsy.•Mammalian target of rapamycin (mTOR) inhibitors offer a targeted therapeutic and…”
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Feasibility of phosphoproteomics to uncover oncogenic signalling in secreted extracellular vesicles using glioblastoma-EGFRVIII cells as a model by Bijnsdorp, Irene V., Schelfhorst, Tim, Luinenburg, Mark, Rolfs, Frank, Piersma, Sander R., de Haas, Richard R., Pham, Thang V., Jimenez, Connie R.

“…Cancer cells secrete extracellular vesicles (EVs) that contain molecular information, including proteins and RNA. Oncogenic signalling can be transferred via…”
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Balloon cells promote immune system activation in focal cortical dysplasia type 2b by Zimmer, Till S., Broekaart, Diede W. M., Luinenburg, Mark, Mijnsbergen, Caroline, Anink, Jasper J., Sim, Nam Suk, Michailidou, Iliana, Jansen, Floor E., Rijen, Peter C., Lee, Jeong Ho, François, Liesbeth, Eyll, Jonathan, Dedeurwaerdere, Stefanie, Vliet, Erwin A., Mühlebner, Angelika, Mills, James D., Aronica, Eleonora

“…Aims Focal cortical dysplasia (FCD) type 2 is an epileptogenic malformation of the neocortex associated with somatic mutations in the mammalian target of…”
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Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period by Korotkov, Anatoly, Luinenburg, Mark J, Romagnolo, Alessia, Zimmer, Till S, van Scheppingen, Jackelien, Bongaarts, Anika, Broekaart, Diede W M, Anink, Jasper J, Mijnsbergen, Caroline, Jansen, Floor E, van Hecke, Wim, Spliet, Wim G, van Rijen, Peter C, Feucht, Martha, Hainfellner, Johannes A, Krsek, Pavel, Zamecnik, Josef, Crino, Peter B, Kotulska, Katarzyna, Lagae, Lieven, Jansen, Anna C, Kwiatkowski, David J, Jozwiak, Sergiusz, Curatolo, Paolo, Mühlebner, Angelika, van Vliet, Erwin A, Mills, James D, Aronica, Eleonora

“…The genetic disorder tuberous sclerosis complex (TSC) is frequently accompanied by the development of neuropsychiatric disorders, including autism spectrum…”
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