Search Results - "Luigi, Racioppi"

CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer by Racioppi, Luigi, Nelson, Erik R., Huang, Wei, Mukherjee, Debarati, Lawrence, Scott A., Lento, William, Masci, Anna Maria, Jiao, Yiquin, Park, Sunghee, York, Brian, Liu, Yaping, Baek, Amy E., Drewry, David H., Zuercher, William J., Bertani, Francesca R., Businaro, Luca, Geradts, Joseph, Hall, Allison, Means, Anthony R., Chao, Nelson, Chang, Ching-yi, McDonnell, Donald P.

“…Tumor-associated myeloid cells regulate tumor growth and metastasis, and their accumulation is a negative prognostic factor for breast cancer. Here we find…”
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Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma by Tomaszewski, William H., Waibl-Polania, Jessica, Chakraborty, Molly, Perera, Jonathan, Ratiu, Jeremy, Miggelbrink, Alexandra, McDonnell, Donald P., Khasraw, Mustafa, Ashley, David M., Fecci, Peter E., Racioppi, Luigi, Sanchez-Perez, Luis, Gunn, Michael D., Sampson, John H.

“…Glioblastoma (GBM) is notorious for its immunosuppressive tumor microenvironment (TME) and is refractory to immune checkpoint blockade (ICB). Here, we identify…”
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Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells by Huang, Wei, Liu, Yaping, Luz, Anthony, Berrong, Mark, Meyer, Joel N, Zou, Yujing, Swann, Excel, Sundaramoorthy, Pasupathi, Kang, Yubin, Jauhari, Shekeab, Lento, William, Chao, Nelson, Racioppi, Luigi

“…Myeloid-derived suppressor cells (MDSCs) are a hetero geneous group of cells, which can suppress the immune response, promote tumor progression and impair the…”
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CXCL12 prolongs naive CD4 + T lymphocytes survival via activation of PKA, CREB and Bcl2 and BclXl up-regulation by Laura, Vitiello, Elisabetta, Ferraro, Salvatore, De Simone, Gatta, Lucia, Feraco, Alessandra, Luigi, Racioppi, Giuseppe, Rosano

“…Abstract Background Naive T lymphocytes recirculate through the body, traveling from secondary lymphoid organs through tissues and via lymphatic vessels and…”
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Inhibition of Ca2+/Calmodulin–Dependent Protein Kinase Kinase 2 Stimulates Osteoblast Formation and Inhibits Osteoclast Differentiation by Cary, Rachel L, Waddell, Seid, Racioppi, Luigi, Long, Fanxin, Novack, Deborah V, Voor, Michael J, Sankar, Uma

“…ABSTRACT Bone remodeling, a physiological process characterized by bone formation by osteoblasts (OBs) and resorption of preexisting bone matrix by osteoclasts…”
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Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration by Racioppi, Luigi, Lento, William, Huang, Wei, Arvai, Stephanie, Doan, Phuong L, Harris, Jeffrey R, Marcon, Fernando, Nakaya, Helder I, Liu, Yaping, Chao, Nelson

“…Hematopoietic stem and progenitor cells (HSPCs) are predominantly quiescent in adults, but proliferate in response to bone marrow (BM) injury. Here, we show…”
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Phylogeny of Toll-like receptor signaling: adapting the innate response by Roach, Jeffrey M, Racioppi, Luigi, Jones, Corbin D, Masci, Anna Maria

“…The Toll-like receptors represent a largely evolutionarily conserved pathogen recognition machinery responsible for recognition of bacterial, fungal,…”
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Serafino Zappacosta: An Enlightened Mentor and Educator by Carbone, Ennio, De Felice, Mario, Di Rosa, Francesca, D'Oro, Ugo, Fontana, Silvia, La Cava, Antonio, Maio, Michele, Matarese, Giuseppe, Racioppi, Luigi, Ruggiero, Giuseppina, Terrazzano, Giuseppe

“…With this article, the authors aim to honor the memory of Serafino Zappacosta, who had been their mentor during the early years of their career in science. The…”
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A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation by Teng, Ellen C., Racioppi, Luigi, Means, Anthony R.

“…Loss of CaMKK2 in myeloid progenitor cells results in enhanced and accelerated granulopoiesis suggesting an inhibitory role for CaMKK2 in early granulocyte…”
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SGC-CAMKK2-1: A Chemical Probe for CAMKK2 by Wells, Carrow, Liang, Yi, Pulliam, Thomas L, Lin, Chenchu, Awad, Dominik, Eduful, Benjamin, O'Byrne, Sean, Hossain, Mohammad Anwar, Catta-Preta, Carolina Moura Costa, Ramos, Priscila Zonzini, Gileadi, Opher, Gileadi, Carina, Couñago, Rafael M, Stork, Brittany, Langendorf, Christopher G, Nay, Kevin, Oakhill, Jonathan S, Mukherjee, Debarati, Racioppi, Luigi, Means, Anthony R, York, Brian, McDonnell, Donald P, Scott, John W, Frigo, Daniel E, Drewry, David H

“…The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes…”
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TLR9 Agonist Acts by Different Mechanisms Synergizing with Bevacizumab in Sensitive and Cetuximab-Resistant Colon Cancer Xenografts by Damiano, Vincenzo, Caputo, Rosa, Garofalo, Sonia, Bianco, Roberto, Rosa, Roberta, Merola, Gerardina, Gelardi, Teresa, Racioppi, Luigi, Fontanini, Gabriella, De Placido, Sabino, Kandimalla, Ekambar R., Agrawal, Sudhir, Ciardiello, Fortunato, Tortora, Giampaolo

“…Synthetic agonists of Toll-like receptor 9 (TLR9), a class of agents that induce specific immune response, exhibit antitumor activity and are currently being…”
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A Novel Toll-Like Receptor 9 Agonist Cooperates with Trastuzumab in Trastuzumab-Resistant Breast Tumors through Multiple Mechanisms of Action by Damiano, Vincenzo, Garofalo, Sonia, Rosa, Roberta, Bianco, Roberto, Caputo, Rosa, Gelardi, Teresa, Merola, Gerardina, Racioppi, Luigi, Garbi, Corrado, Kandimalla, Ekambar R, Agrawal, Sudhir, Tortora, Giampaolo

“…Purpose: Resistance to anti-HER2 monoclonal antibody trastuzumab is a relevant issue in breast cancer patients. Among the mechanisms implicated in trastuzumab…”
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The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice by Barberi, Theresa J, Dunkle, Alexis, He, You-Wen, Racioppi, Luigi, Means, Anthony R

“…Pin1 has previously been described to regulate cells that participate in both innate and adaptive immunity. Thus far, however, no role for Pin1 has been…”
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Dendritic cells/natural killer cross-talk: a novel target for human immunodeficiency virus type-1 protease inhibitors by Giardino Torchia, Maria Letizia, Ciaglia, Elena, Masci, Anna Maria, Vitiello, Laura, Fogli, Manuela, la Sala, Andrea, Mavilio, Domenico, Racioppi, Luigi

“…HIV-1 Protease Inhibitors, namely PIs, originally designed to inhibit HIV-1 aspartic protease, can modulate the immune response by mechanisms largely unknown,…”
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Helicobacter pylori Induces Apoptosis of Human Monocytes but Not Monocyte-Derived Dendritic Cells: Role of the cag Pathogenicity Island by GALGANI, Mario, BUSIELLO, Immacolata, CENSINI, Stefano, ZAPPACOSTA, Serafino, RACIOPPI, Luigi, ZARRILLI, Raffaele

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem by Racioppi, Luigi

“…Highlights ► Outside the brain, CaMKK2 is expressed in few cell types. ► CaMKK2 is barely detectable in normal prostate. ► CaMKK2 is overexpressed in prostate…”
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Cyclic AMP Modulates the Functional Plasticity of Immature Dendritic Cells by Inhibiting Src-like Kinases through Protein Kinase A-mediated Signaling by Galgani, Mario, De Rosa, Veronica, De Simone, Salvatore, Leonardi, Antonio, D'Oro, Ugo, Napolitani, Giorgio, Masci, Anna Maria, Zappacosta, Serafino, Racioppi, Luigi

“…Immature dendritic cells (iDCs) can be instructed to polarize the immune response toward a noninflammatory pathway by mediators that increase the intracellular…”
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Calcium/Calmodulin-dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology by Racioppi, Luigi, Means, Anthony R.

“…Many cellular Ca2+-dependent signaling cascades utilize calmodulin (CaM) as the intracellular Ca2+ receptor. Ca2+/CaM binds and activates a plethora of…”
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Early-onset monocyte–B–natural killer–dendritic cells’ deficiency successfully treated with hematopoietic stem cell transplantation by Cancrini, Caterina, MD, PhD, Scarselli, Alessia, MD, Scaramuzza, Samantha, BSc, PhD, Chiriaco, Maria, BSc, PhD, Di Cesare, Silvia, BSc, Di Matteo, Gigliola, BSc, PhD, Romiti, Maria Luisa, BSc, PhD, Palma, Paolo, MD, PhD, De Felice, Lidia, BSc, Palumbo, Giuseppe, MD, PhD, Pinto, Rita Maria, MD, De Vito, Rita, MD, Racioppi, Luigi, MD, PhD, Livadiotti, Susanna, MD, Fischer, Alain, MD, PhD, Rossi, Paolo, MD, PhD, Caniglia, Maurizio, MD, Aiuti, Alessandro, MD, PhD

“…[...]she developed septicemia and severe lung infections poorly responsive to antimicrobial therapy with the deterioration of respiratory functions and…”
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HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling by Masci, Anna Maria, Galgani, Mario, Cassano, Silvana, De Simone, Salvatore, Gallo, Adriana, De Rosa, Veronica, Zappacosta, Serafino, Racioppi, Luigi

“…The ability of the envelope glycoprotein gp120 [human immunodeficiency virus (HIV) env] to induce intracellular signals is thought to contribute to HIV‐1…”
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