Search Results - "Lui, Goldie Y L"

Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer by Cao, Joan, Zhu, Zhou, Wang, Hui, Nichols, Timothy C., Lui, Goldie Y. L., Deng, Shibing, Rejto, Paul A., VanArsdale, Todd, Hardwick, James S., Weinrich, Scott L., Wei, Ping

“…The CDK4/6 inhibitor palbociclib reduces tumor growth by decreasing retinoblastoma (RB) protein phosphorylation and inducing cell cycle arrest at the G1/S…”
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The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways by Kovacevic, Zaklina, Chikhani, Sherin, Lui, Goldie Y L, Sivagurunathan, Sutharshani, Richardson, Des R

“…The metastasis suppressor gene, N-myc downstream regulated gene-1 (NDRG1), is negatively correlated with tumor progression in multiple neoplasms, including…”
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The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action by Lui, Goldie Y L, Obeidy, Peyman, Ford, Samuel J, Tselepis, Chris, Sharp, Danae M, Jansson, Patric J, Kalinowski, Danuta S, Kovacevic, Zaklina, Lovejoy, David B, Richardson, Des R

“…Deferasirox is an orally effective iron (Fe) chelator currently used for the treatment of iron-overload disease and has been implemented as an alternative to…”
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RAB27A promotes melanoma cell invasion and metastasis via regulation of pro‐invasive exosomes by Guo, Dajiang, Lui, Goldie Y.L., Lai, Siew Li, Wilmott, James S., Tikoo, Shweta, Jackett, Louise A., Quek, Camelia, Brown, Darren L., Sharp, Danae M., Kwan, Rain Y.Q., Chacon, Diego, Wong, Jason H., Beck, Dominik, Geldermalsen, Michelle, Holst, Jeff, Thompson, John F., Mann, Graham J., Scolyer, Richard A., Stow, Jennifer L., Weninger, Wolfgang, Haass, Nikolas K., Beaumont, Kimberley A.

“…Despite recent advances in targeted and immune‐based therapies, advanced stage melanoma remains a clinical challenge with a poor prognosis. Understanding the…”
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CDK12: an emerging therapeutic target for cancer by Lui, Goldie Y L, Grandori, Carla, Kemp, Christopher J

“…Cyclin-dependent kinase 12 (CDK12) belongs to the cyclin-dependent kinase (CDK) family of serine/threonine protein kinases that regulate transcriptional and…”
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Targeting cancer by binding iron: Dissecting cellular signaling pathways by Lui, Goldie Y L, Kovacevic, Zaklina, Richardson, Vera, Merlot, Angelica M, Kalinowski, Danuta S, Richardson, Des R

“…Newer and more potent therapies are urgently needed to effectively treat advanced cancers that have developed resistance and metastasized. One such strategy is…”
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Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma by Shigeta, Shogo, Lui, Goldie Y L, Shaw, Reid, Moser, Russell, Gurley, Kay E, Durenberger, Grace, Rosati, Rachele, Diaz, Robert L, Ince, Tan A, Swisher, Elizabeth M, Grandori, Carla, Kemp, Christopher J

“…Ovarian clear cell carcinoma (OCCC) is a rare, chemo-resistant subtype of ovarian cancer. To identify novel therapeutic targets and combination therapies for…”
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Cell Cycle Phase-Specific Drug Resistance as an Escape Mechanism of Melanoma Cells by Beaumont, Kimberley A., Hill, David S., Daignault, Sheena M., Lui, Goldie Y.L., Sharp, Danae M., Gabrielli, Brian, Weninger, Wolfgang, Haass, Nikolas K.

“…The tumor microenvironment is characterized by cancer cell subpopulations with heterogeneous cell cycle profiles. For example, hypoxic tumor zones contain…”
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Abrogation of RAB27A expression transiently affects melanoma cell proliferation by Guo, Dajiang, Beaumont, Kimberley A., Sharp, Danae M., Lui, Goldie Y. L., Weninger, Wolfgang, Haass, Nikolas K., Tikoo, Shweta

“…The role of the small GTPase RAB27A as an essential melanosome trafficking regulator in melanocytes is well‐accepted. A decade ago, RAB27A was identified as a…”
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Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion by Lui, Goldie Y L, Kovacevic, Zaklina, V Menezes, Sharleen, Kalinowski, Danuta S, Merlot, Angelica M, Sahni, Sumit, Richardson, Des R

“…Pharmacologic manipulation of metal pools in tumor cells is a promising strategy for cancer treatment. Here, we reveal how the iron-binding ligands…”
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BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer by Lui, Goldie Y.L., Shaw, Reid, Schaub, Franz X., Stork, Isabella N., Gurley, Kay E., Bridgwater, Caroline, Diaz, Robert L., Rosati, Rachele, Swan, Hallie A., Ince, Tan A., Harding, Thomas C., Gadi, Vijayakrishna K., Goff, Barbara A., Kemp, Christopher J., Swisher, Elizabeth M., Grandori, Carla

“…Homologous recombination deficiencies (HRD) are present in approximately half of epithelial ovarian cancers, for which PARP inhibitors (PARPi) are becoming a…”
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Abstract A28: Casein kinase 1ε (CSNK1ε) is a synthetic lethal target in MYC-driven ovarian cancer by Lui, Goldie Y. L., Schaub, Franz, Agrawal, Shaifali, Kitatani, Kazuyuki, Kemp, Christopher J., Toyoshima, Masafumi, Grandori, Carla

“…Abstract The MYC family of oncogenes encodes transcription factors that are master regulators of cell proliferation and is a central driver in many human…”
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Abstract A232: Novel thiosemicarbazones with potent antitumor and antimetastatic activity inhibit the signal transducer and activator of transcription (STAT) pathway by Lui, Goldie Y. L., Kovacevic, Zaklina, Richardson, Des R.

“…Abstract Background: Novel thiosemicarbazones that bind iron [i.e., di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) & di-2-pyridylketone…”
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