Search Results - "Luhmann, Heiko J"

Transient cortical circuits match spontaneous and sensory-driven activity during development by Molnár, Zoltán, Luhmann, Heiko J, Kanold, Patrick O

“…At the earliest developmental stages, spontaneous activity synchronizes local and large-scale cortical networks. These networks form the functional template…”
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Neuronal activity patterns in the developing barrel cortex by Luhmann, Heiko J, Khazipov, Rustem

“…Graphical abstract…”
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Malformations-related neocortical circuits in focal seizures by Luhmann, Heiko J.

“…This review article gives an overview on the molecular, cellular and network mechanisms underlying focal seizures in neocortical networks with developmental…”
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Models of cortical malformation—Chemical and physical by Luhmann, Heiko J.

“…•Chemical and physical manipulations during early development induce cortical malformations.•These malformations resemble cortical pathologies in humans with…”
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Neurophysiology of the Developing Cerebral Cortex: What We Have Learned and What We Need to Know by Luhmann, Heiko J

“…This review article aims to give a brief summary on the novel technologies, the challenges, our current understanding, and the open questions in the field of…”
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The Subplate and Early Cortical Circuits by KANOLD, Patrick O, LUHMANN, Heiko J

“…The developing mammalian cerebral cortex contains a distinct class of cells, subplate neurons (SPns), that play an important role during early development…”
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Control of cortical neuronal migration by glutamate and GABA by Luhmann, Heiko J, Fukuda, A, Kilb, W

“…Neuronal migration in the cortex is controlled by the paracrine action of the classical neurotransmitters glutamate and GABA. Glutamate controls radial…”
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Effects of Mutations in TSC Genes on Neurodevelopment and Synaptic Transmission by Bassetti, Davide, Luhmann, Heiko J, Kirischuk, Sergei

“…Mutations in TSC1 or TSC2 genes are linked to alterations in neuronal function which ultimately lead to the development of a complex neurological phenotype…”
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Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation by Fröhlich, Dominik, Kuo, Wen Ping, Frühbeis, Carsten, Sun, Jyh-Jang, Zehendner, Christoph M., Luhmann, Heiko J., Pinto, Sheena, Toedling, Joern, Trotter, Jacqueline, Krämer-Albers, Eva-Maria

“…Exosomes are small membranous vesicles of endocytic origin that are released by almost every cell type. They exert versatile functions in intercellular…”
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Homeostatic interplay between electrical activity and neuronal apoptosis in the developing neocortex by Blanquie, Oriane, Kilb, Werner, Sinning, Anne, Luhmann, Heiko J.

“…[Display omitted] •Neuronal apoptosis is a key event of mammalian brain development.•In the cortex, apoptosis co-occurs with spontaneous synchronous Ca2+…”
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Early patterns of electrical activity in the developing cerebral cortex of humans and rodents by KHAZIPOV, Rustem, LUHMANN, Heiko J

“…During prenatal and early postnatal development, the cerebral cortex exhibits synchronized oscillatory network activity that is believed to be essential for…”
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Electrical activity patterns and the functional maturation of the neocortex by Kilb, Werner, Kirischuk, Sergei, Luhmann, Heiko J.

“…At the earliest developmental stages, sensory neocortical areas in various species reveal distinct patterns of spontaneous neuronal network activity. These…”
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Can we understand human brain development from experimental studies in rodents? by Luhmann, Heiko J., Fukuda, Atsuo

“…Animal models are needed to gain an understanding of the genetic, molecular, cellular, and network mechanisms of human brain development. In rodents, a large…”
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Cellular mechanisms of IL-17-induced blood-brain barrier disruption by Huppert, Jula, Closhen, Dorothea, Croxford, Andrew, White, Robin, Kulig, Paulina, Pietrowski, Eweline, Bechmann, Ingo, Becher, Burkhard, Luhmann, Heiko J, Waisman, Ari, Kuhlmann, Christoph R.W

“…Recently T-helper 17 (Th17) cells were demonstrated to disrupt the blood-brain barrier (BBB) by the action of IL-17A. The aim of the present study was to…”
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The Superior Function of the Subplate in Early Neocortical Development by Luhmann, Heiko J, Kirischuk, Sergei, Kilb, Werner

“…During early development the structure and function of the cerebral cortex is critically organized by subplate neurons (SPNs), a mostly transient population of…”
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Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons by Lombardi, Aniello, Jedlicka, Peter, Luhmann, Heiko J, Kilb, Werner

“…The impact of GABAergic transmission on neuronal excitability depends on the Cl--gradient across membranes. However, the Cl--fluxes through GABAA receptors…”
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Spontaneous Neuronal Activity in Developing Neocortical Networks: From Single Cells to Large-Scale Interactions by Luhmann, Heiko J, Sinning, Anne, Yang, Jenq-Wei, Reyes-Puerta, Vicente, Stüttgen, Maik C, Kirischuk, Sergei, Kilb, Werner

“…Neuronal activity has been shown to be essential for the proper formation of neuronal circuits, affecting developmental processes like neurogenesis, migration,…”
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Haploinsufficiency of Tsc2 Leads to Hyperexcitability of Medial Prefrontal Cortex via Weakening of Tonic GABAB Receptor-mediated Inhibition by Bassetti, Davide, Lombardi, Aniello, Kirischuk, Sergei, Luhmann, Heiko J

“…Abstract Loss-of-function mutation in one of the tumor suppressor genes TSC1 or TSC2 is associated with several neurological and psychiatric diseases,…”
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Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex by Zehendner, Christoph M., Sebastiani, Anne, Hugonnet, André, Bischoff, Florian, Luhmann, Heiko J., Thal, Serge C.

“…Accumulating evidence suggests a pivotal role of PDGFRß positive cells, a specific marker for central nervous system (CNS) pericytes, in tissue scarring…”
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Laminar and Columnar Structure of Sensory-Evoked Multineuronal Spike Sequences in Adult Rat Barrel Cortex In Vivo by Reyes-Puerta, Vicente, Sun, Jyh-Jang, Kim, Suam, Kilb, Werner, Luhmann, Heiko J

“…One of the most relevant questions regarding the function of the nervous system is how sensory information is represented in populations of cortical neurons…”
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