Search Results - "Lugovskoy, Alexey A."

MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM by Casaletto, Jessica B., Geddie, Melissa L., Abu-Yousif, Adnan O., Masson, Kristina, Fulgham, Aaron, Boudot, Antoine, Maiwald, Tim, Kearns, Jeffrey D., Kohli, Neeraj, Su, Stephen, Razlog, Maja, Raue, Andreas, Kalra, Ashish, Håkansson, Maria, Logan, Derek T., Welin, Martin, Chattopadhyay, Shrikanta, Harms, Brian D., Nielsen, Ulrik B., Schoeberl, Birgit, Lugovskoy, Alexey A., MacBeath, Gavin

“…Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as MET…”
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Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies by Harms, Brian D., Kearns, Jeffrey D., Iadevaia, Sergio, Lugovskoy, Alexey A.

“…•Simultaneous engagement of functional arms in monoclonal and multispecific antibodies is essential component of their activity.•Optimization of cross-arm…”
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Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics by Geddie, Melissa L, Kirpotin, Dmitri B, Kohli, Neeraj, Kornaga, Tad, Boll, Bjoern, Razlog, Maja, Drummond, Daryl C, Lugovskoy, Alexey A

“…Antibody-directed nanotherapeutics (ADNs) represent a promising delivery platform for selective delivery of an encapsulated drug payload to the site of disease…”
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Proteome-wide Analysis in Saccharomyces cerevisiae Identifies Several PHD Fingers as Novel Direct and Selective Binding Modules of Histone H3 Methylated at Either Lysine 4 or Lysine 36 by Shi, Xiaobing, Kachirskaia, Ioulia, Walter, Kay L., Kuo, Jen-Hao A., Lake, Aimee, Davrazou, Foteini, Chan, Steve M., Martin, David G.E., Fingerman, Ian M., Briggs, Scott D., Howe, LeAnn, Utz, Paul J., Kutateladze, Tatiana G., Lugovskoy, Alexey A., Bedford, Mark T., Gozani, Or

“…The PHD finger motif is a signature chromatin-associated motif that is found throughout eukaryotic proteomes. Here we have determined the histone methyl-lysine…”
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Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E by Gross, John D., Moerke, Nathan J., von der Haar, Tobias, Lugovskoy, Alexey A., Sachs, Alan B., McCarthy, John E.G., Wagner, Gerhard

“…The eukaryotic initiation factor 4G (eIF4G) is the core of a multicomponent switch controlling gene expression at the level of translation initiation. It…”
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Fast screening of protein surfaces using geometric invariant fingerprints by Yin, Shuangye, Proctor, Elizabeth A, Lugovskoy, Alexey A, Dokholyan, Nikolay V

“…We develop a rapid and efficient method for the comparison of protein local surface similarities using geometric invariants (fingerprints). By combining fast…”
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Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle by Zhang, Kathy, Geddie, Melissa L, Kohli, Neeraj, Kornaga, Tad, Kirpotin, Dmitri B, Jiao, Yang, Rennard, Rachel, Drummond, Daryl C, Nielsen, Ulrik B, Xu, Lihui, Lugovskoy, Alexey A

“…Antibody-targeted nanoparticles have the potential to significantly increase the therapeutic index of cytotoxic anti-cancer therapies by directing them to…”
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Conserved amino acid networks involved in antibody variable domain interactions by Wang, Norman, Smith, William F., Miller, Brian R., Aivazian, Dikran, Lugovskoy, Alexey A., Reff, Mitchell E., Glaser, Scott M., Croner, Lisa J., Demarest, Stephen J.

“…Engineered antibodies are a large and growing class of protein therapeutics comprising both marketed products and many molecules in clinical trials in various…”
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A Novel Approach for Characterizing Protein Ligand Complexes:  Molecular Basis for Specificity of Small-Molecule Bcl-2 Inhibitors by Lugovskoy, Alexey A, Degterev, Alexei I, Fahmy, Amr F, Zhou, Pei, Gross, John D, Yuan, Junying, Wagner, Gerhard

“…The increasing diversity of small molecule libraries has been an important source for the development of new drugs and, more recently, for unraveling the…”
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A novel screening method to assess developability of antibody-like molecules by Kohli, Neeraj, Jain, Nidhi, Geddie, Melissa L, Razlog, Maja, Xu, Lihui, Lugovskoy, Alexey A

“…Monoclonal antibodies and antibody-like molecules represent a fast-growing class of bio-therapeutics that has rapidly transformed patient care in a variety of…”
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7th Annual European Antibody Congress 2011: November 29–December 1, 2011, Geneva, Switzerland by Lugovskoy, Alexey A, Reichert, Janice M, Beck, Alain

“…The 7th European Antibody Congress (EAC), organized by Terrapin Ltd., was again held in Geneva, Switzerland, following on the tradition established with the…”
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Solution Structure of DFF40 and DFF45 N-Terminal Domain Complex and Mutual Chaperone Activity of DFF40 and DFF45 by Zhou, Pei, Lugovskoy, Alexey A., McCarty, John S., Li, Peng, Wagner, Gerhard

“…Apoptotic DNA fragmentation is mediated by a caspase-activated DNA fragmentation factor (DFF)40. Expression and folding of DFF40 require the presence of DFF45,…”
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MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors by Fitzgerald, Jonathan B, Johnson, Bryan W, Baum, Jason, Adams, Sharlene, Iadevaia, Sergio, Tang, Jian, Rimkunas, Victoria, Xu, Lihui, Kohli, Neeraj, Rennard, Rachel, Razlog, Maja, Jiao, Yang, Harms, Brian D, Olivier, Jr, Kenneth J, Schoeberl, Birgit, Nielsen, Ulrik B, Lugovskoy, Alexey A

“…Although inhibition of the insulin-like growth factor (IGF) signaling pathway was expected to eliminate a key resistance mechanism for EGF receptor…”
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Solution Structure of the CIDE-N Domain of CIDE-B and a Model for CIDE-N/CIDE-N Interactions in the DNA Fragmentation Pathway of Apoptosis by Lugovskoy, Alexey A, Zhou, Pei, Chou, James J, McCarty, John S, Li, Peng, Wagner, Gerhard

“…Apoptotic DNA fragmentation and chromatin condensation are mediated by the caspase-activated DFF40/CAD nuclease, which is chaperoned and inhibited by…”
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Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer by Camblin, Adam J, Pace, Emily A, Adams, Sharlene, Curley, Michael D, Rimkunas, Victoria, Nie, Lin, Tan, Gege, Bloom, Troy, Iadevaia, Sergio, Baum, Jason, Minx, Charlene, Czibere, Akos, Louis, Chrystal U, Drummond, Daryl C, Nielsen, Ulrik B, Schoeberl, Birgit, Pipas, J Marc, Straubinger, Robert M, Askoxylakis, Vasileios, Lugovskoy, Alexey A

“…Insulin-like growth factor receptor 1 (IGF-1R) is critically involved in pancreatic cancer pathophysiology, promoting cancer cell survival and therapeutic…”
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Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer by Camblin, Adam J., Tan, Gege, Curley, Michael D., Yannatos, Isabel, Iadevaia, Sergio, Rimkunas, Victoria, Mino-Kenudson, Mari, Bloom, Troy, Schoeberl, Birgit, Drummond, Daryl C., Lugovskoy, Alexey A., Louis, Chrystal U., Askoxylakis, Vasileios

“…Therapeutically targeting receptor tyrosine kinases has proven to be paramount to overcoming chemotherapy resistance in several cancer indications, improving…”
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De novo discovery of antibody drugs - great promise demands scrutiny by Finlay, William J.J., Lugovskoy, Alexey A.

“…We live in an era of rapidly advancing computing capacity and algorithmic sophistication. "Big data" and "artificial intelligence"find progressively wider use…”
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Small-Molecule Inhibition of TNF-α by He, Molly M., Smith, Annemarie Stroustrup, Oslob, Johan D., Flanagan, William M., Braisted, Andrew C., Whitty, Adrian, Cancilla, Mark T., Wang, Jun, Lugovskoy, Alexey A., Yoburn, Josh C., Fung, Amy D., Farrington, Graham, Eldredge, John K., Day, Eric S., Cruz, Leslie A., Cachero, Teresa G., Miller, Stephan K., Friedman, Jessica E., Choong, Ingrid C., Cunningham, Brian C.

“…We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that promotes subunit disassembly of this trimeric cytokine family member. The…”
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Improving the developability of an anti-EphA2 single-chain variable fragment for nanoparticle targeting by Geddie, Melissa L, Kohli, Neeraj, Kirpotin, Dmitri B, Razlog, Maja, Jiao, Yang, Kornaga, Tad, Rennard, Rachel, Xu, Lihui, Schoerberl, Birgit, Marks, James D, Drummond, Daryl C, Lugovskoy, Alexey A

“…Antibody-targeted nanoparticles have great promise as anti-cancer drugs; however, substantial developmental challenges of antibody modules prevent many…”
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The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor by Gozani, Or, Karuman, Philip, Jones, David R., Ivanov, Dmitri, Cha, James, Lugovskoy, Alexey A., Baird, Cheryl L., Zhu, Hong, Field, Seth J., Lessnick, Stephen L., Villasenor, Jennifer, Mehrotra, Bharat, Chen, Jian, Rao, Vikram R., Brugge, Joan S., Ferguson, Colin G., Payrastre, Bernard, Myszka, David G., Cantley, Lewis C., Wagner, Gerhard, Divecha, Nullin, Prestwich, Glenn D., Yuan, Junying

“…Phosphoinositides (PtdInsPs) play critical roles in cytoplasmic signal transduction pathways. However, their functions in the nucleus are unclear, as specific…”
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