Search Results - "Lugg, Sebastian T."

Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease by Lugg, Sebastian T, Scott, Aaron, Parekh, Dhruv, Naidu, Babu, Thickett, David R

“…Cigarette smoking is the leading cause of preventable death worldwide. It causes chronic lung disease and predisposes individuals to acute lung injury and…”
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Long-term impact of developing a postoperative pulmonary complication after lung surgery by Lugg, Sebastian T, Agostini, Paula J, Tikka, Theofano, Kerr, Amy, Adams, Kerry, Bishay, Ehab, Kalkat, Maninder S, Steyn, Richard S, Rajesh, Pala B, Thickett, David R, Naidu, Babu

“…Postoperative pulmonary complications (PPC) such as atelectasis and pneumonia are common following lung resection. PPCs have a significant clinical impact on…”
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Risk factors and short-term outcomes of postoperative pulmonary complications after VATS lobectomy by Agostini, Paula J, Lugg, Sebastian T, Adams, Kerry, Smith, Tom, Kalkat, Maninder S, Rajesh, Pala B, Steyn, Richard S, Naidu, Babu, Rushton, Alison, Bishay, Ehab

“…Postoperative pulmonary complications (PPCs) are associated with poor outcomes following thoracotomy and lung resection. Video-assisted thoracoscopic surgery…”
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Smoking and timing of cessation on postoperative pulmonary complications after curative-intent lung cancer surgery by Lugg, Sebastian T, Tikka, Theofano, Agostini, Paula J, Kerr, Amy, Adams, Kerry, Kalkat, Maninder S, Steyn, Richard S, Rajesh, Pala B, Bishay, Ehab, Thickett, David R, Naidu, Babu

“…Smoking is a risk factor for postoperative pulmonary complications (PPC) following non-small cell lung cancer (NSCLC) surgery. The optimal timing for…”
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Feasibility study of a randomised controlled trial of preoperative and postoperative nutritional supplementation in major lung surgery by Kerr, Amy, Lugg, Sebastian T, Kadiri, Salma, Swift, Amelia, Efstathiou, Nikolaos, Kholia, Krishna, Rogers, Venessa, Fallouh, Hazem, Steyn, Richard, Bishay, Ehab, Kalkat, Maninder, Naidu, Babu

“…ObjectivesMalnutrition and weight loss are important risk factors for complications after lung surgery. However, it is uncertain whether modifying or…”
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Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation by Roberts, Alexander, Bentley, Lindsay, Tang, Tina, Stewart, Fay, Pallini, Chiara, Juvvanapudi, Joel, Wallace, Graham R., Cooper, Alison J., Scott, Aaron, Thickett, David, Lugg, Sebastian T., Bancroft, Hollie, Hemming, Bridget, Ferris, Charlotte, Langman, Gerald, Robinson, Andrew, Chapman, Joanne, Naidu, Babu, Pinkney, Thomas, Taylor, Graham S., Brock, Kristian, Stamataki, Zania, Brady, Catherine A., Curnow, S. John, Gordon, John, Qureshi, Omar, Barnes, Nicholas M.

“…Blockade of PD-1/PD-L1 interactions is proving an exciting, durable therapeutic modality in a range of cancers whereby T cells are released from checkpoint…”
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Multiple simultaneous embolic cerebral infarctions 11 months after COVID-19 by Advani, Rajiv, Stramsnes, Torbjarn Austveg, Stjernstram, Espen, Lugg, Sebastian T

“…Background The coronavirus disease (COVID-19) pandemic has led to an unprecedented worldwide burden of disease. However, little is known of the longer-term…”
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Dysregulated Neutrophil Phenotype and Function in Hospitalised Non-ICU COVID-19 Pneumonia by Belchamber, Kylie B R, Thein, Onn S, Hazeldine, Jon, Grudzinska, Frances S, Faniyi, Aduragbemi A, Hughes, Michael J, Jasper, Alice E, Yip, Kay Por, Crowley, Louise E, Lugg, Sebastian T, Sapey, Elizabeth, Parekh, Dhruv, Thickett, David R, Scott, Aaron

“…: Infection with the SARS-CoV2 virus is associated with elevated neutrophil counts. Evidence of neutrophil dysfunction in COVID-19 is based on transcriptomics…”
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COVID-19 admission risk tools should include multiethnic age structures, multimorbidity and deprivation metrics for air pollution, household overcrowding, housing quality and adult skills by Soltan, Marina A, Varney, Justin, Sutton, Benjamin, Melville, Colin R, Lugg, Sebastian T, Parekh, Dhruv, Carroll, Will, Dosanjh, Davinder P, Thickett, David R

“…BackgroundEthnic minorities account for 34% of critically ill patients with COVID-19 despite constituting 14% of the UK population. Internationally,…”
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Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome by Mahida, Rahul Y, Scott, Aaron, Parekh, Dhruv, Lugg, Sebastian T, Belchamber, Kylie B R, Hardy, Rowan S, Matthay, Michael A, Naidu, Babu, Thickett, David R

“…Impaired alveolar macrophage (AM) efferocytosis may contribute to acute respiratory distress syndrome (ARDS) pathogenesis; however, studies are limited by the…”
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Vitamin D status: a U-shaped relationship for SARS-CoV-2 seropositivity in UK healthcare workers by Lugg, Sebastian T, Mackay, William R, Faniyi, Aduragbemi A, Faustini, Sian E, Webster, Craig, Duffy, Joanne E, Hewison, Martin, Shields, Adrian M, Parekh, Dhruv, Richter, Alex G, Scott, Aaron, Thickett, David R

“…BackgroundThere is increasing evidence that vitamin D (VD) deficiency may increase individuals’ risk of COVID-19 infection and susceptibility. We aimed to…”
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Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages by Scott, Aaron, Lugg, Sebastian T, Aldridge, Kerrie, Lewis, Keir E, Bowden, Allen, Mahida, Rahul Y, Grudzinska, Frances Susanna, Dosanjh, Davinder, Parekh, Dhruv, Foronjy, Robert, Sapey, Elizabeth, Naidu, Babu, Thickett, David R

“…Vaping may increase the cytotoxic effects of e-cigarette liquid (ECL). We compared the effect of unvaped ECL to e-cigarette vapour condensate (ECVC) on…”
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Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia. A Pilot Randomized Controlled Clinical Trial by Sapey, Elizabeth, Patel, Jaimin M, Greenwood, Hannah, Walton, Georgia M, Grudzinska, Frances, Parekh, Dhruv, Mahida, Rahul Y, Dancer, Rachel C A, Lugg, Sebastian T, Howells, Philip A, Hazeldine, Jon, Newby, Paul, Scott, Aaron, Nightingale, Peter, Hill, Adam T, Thickett, David R

“…Population studies suggest improved sepsis outcomes with statins, but the results of randomized controlled trials in patients with sepsis and organ dysfunction…”
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Dysregulated alveolar function and complications in smokers following oesophagectomy by Lugg, Sebastian T, Alridge, Kerrie A, Howells, Phillip A, Parekh, Dhruv, Scott, Aaron, Mahida, Rahul Y, Park, Daniel, Tucker, Olga, Gao, Fang, Perkins, Gavin D, Thickett, David R, Dancer, Rachel C A

“…Acute respiratory distress syndrome (ARDS) has a significant impact on post-operative morbidity and mortality following oesophagectomy. Smoking is a risk…”
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Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis by Mahida, Rahul Y, Scott, Aaron, Parekh, Dhruv, Lugg, Sebastian T, Hardy, Rowan S, Lavery, Gareth G, Matthay, Michael A, Naidu, Babu, Perkins, Gavin D, Thickett, David R

“…Acute respiratory distress syndrome (ARDS) is an inflammatory disorder of the lungs, with sepsis as the predominant aetiology. Despite advances in ventilation…”
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CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome by Mahida, Rahul Y, Price, Joshua, Lugg, Sebastian T, Li, Hui, Parekh, Dhruv, Scott, Aaron, Harrison, Paul, Matthay, Michael A, Thickett, David R

“…Recent studies have indicated that extracellular vesicles (EVs) may play a role in the pathogenesis of acute respiratory distress syndrome (ARDS). EVs have…”
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Vitamin D status and seroconversion for COVID-19 in UK healthcare workers by Faniyi, Aduragbemi A, Lugg, Sebastian T, Faustini, Sian E, Webster, Craig, Duffy, Joanne E, Hewison, Martin, Shields, Adrian, Nightingale, Peter, Richter, Alex G, Thickett, David R

“…The coronavirus disease 2019 (COVID-19) pandemic is a global health emergency, resulting in over 50 million infections and over 1.2 million deaths as of…”
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Postoperative pulmonary complications and rehabilitation requirements following lobectomy: a propensity score matched study of patients undergoing video-assisted thoracoscopic surgery versus thoracotomy by Agostini, Paula, Lugg, Sebastian T., Adams, Kerry, Vartsaba, Nelia, Kalkat, Maninder S., Rajesh, Pala B., Steyn, Richard S., Naidu, Babu, Rushton, Alison, Bishay, Ehab

“…Abstract OBJECTIVES: Video-assisted thoracoscopic surgical (VATS) lobectomy is increasingly used for curative intent lung cancer surgery compared to open…”
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Optimal Vitamin D Supplementation Levels for Cardiovascular Disease Protection by Lugg, Sebastian T., Thickett, David R., Howells, Phillip A.

“…First described in relation to musculoskeletal disease, there is accumulating data to suggest that vitamin D may play an important role in cardiovascular…”
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Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19 by Speeckaert, Marijn M, Speeckaert, Reinhart, Delanghe, Joris R

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