Search Results - "Lugert, Sebastian"

A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes by Giachino, Claudio, Boulay, Jean-Louis, Ivanek, Robert, Alvarado, Alvaro, Tostado, Cristobal, Lugert, Sebastian, Tchorz, Jan, Coban, Mustafa, Mariani, Luigi, Bettler, Bernhard, Lathia, Justin, Frank, Stephan, Pfister, Stefan, Kool, Marcel, Taylor, Verdon

“…In the brain, Notch signaling maintains normal neural stem cells, but also brain cancer stem cells, indicating an oncogenic role. Here, we identify an…”
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Molecular Diversity Subdivides the Adult Forebrain Neural Stem Cell Population by Giachino, Claudio, Basak, Onur, Lugert, Sebastian, Knuckles, Philip, Obernier, Kirsten, Fiorelli, Roberto, Frank, Stephan, Raineteau, Olivier, Alvarez‐Buylla, Arturo, Taylor, Verdon

“…Neural stem cells (NSCs) in the ventricular domain of the subventricular zone (V‐SVZ) of rodents produce neurons throughout life while those in humans become…”
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mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis by Costa, Veronica, Aigner, Stefan, Vukcevic, Mirko, Sauter, Evelyn, Behr, Katharina, Ebeling, Martin, Dunkley, Tom, Friedlein, Arno, Zoffmann, Sannah, Meyer, Claas A., Knoflach, Frédéric, Lugert, Sebastian, Patsch, Christoph, Fjeldskaar, Fatiha, Chicha-Gaudimier, Laurie, Kiialainen, Anna, Piraino, Paolo, Bedoucha, Marc, Graf, Martin, Jessberger, Sebastian, Ghosh, Anirvan, Bischofberger, Josef, Jagasia, Ravi

“…Hyperfunction of the mTORC1 pathway has been associated with idiopathic and syndromic forms of autism spectrum disorder (ASD), including tuberous sclerosis,…”
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Establishing standardized immune phenotyping of metastatic melanoma by digital pathology by Sobottka, Bettina, Nowak, Marta, Frei, Anja Laura, Haberecker, Martina, Merki, Samuel, Levesque, Mitchell P., Dummer, Reinhard, Moch, Holger, Ak, Melike, Albinus, Jonas, Alborelli, Ilaria, Andani, Sonali, Attinger, Per-Olof, Bacac, Marina, Baumhoer, Daniel, Beck-Schimmer, Beatrice, Beerenwinkel, Niko, Beisel, Christian, Bernasconi, Lara, Bodenmiller, Bernd, Bonilla, Ximena, Casanova, Ruben, Chevrier, Stéphane, Chicherova, Natalia, D'Costa, Maya, Danenberg, Esther, Davidson, Natalie, Drăganmoch, Monica-Andreea, Engler, Stefanie, Erkens, Martin, Eschbach, Katja, Esposito, Cinzia, Ferreira, Pedro, Ficek, Joanna, Grob, Linda, Gut, Gabriele, Günther, Detlef, Haberecker, Martina, Haeuptle, Pirmin, Holtackers, Rene, Huesser, Tamara, Irmisch, Anja, Jacob, Francis, Jacobs, Andrea, Jaeger, Tim M., Kahles, André, Kahraman, Abdullah, Kuebler, Werner, Kuipers, Jack, Kunze, Christian P., Kurzeder, Christian, Lehmann, Kjong-Van, Lugert, Sebastian, Maass, Gerd, Manz, Markus G., Markolin, Philipp, Mena, Julien, Menzel, Ulrike, Metzler, Julian M., Miglino, Nicola, Muenst, Simone, Murri, Riccardo, Ng, Charlotte K.Y., Nicolet, Stefan, Pedrioli, Patrick G.A., Pelkmans, Lucas, Piscuoglio, Salvatore, Ritter, Mathilde, Rosano-González, María L., Rätsch, Gunnar, Santacroce, Natascha, del Castillo, Jacobo Sarabia, Schlenker, Ramona, Schwalie, Petra C., Schwan, Severin, Senti, Gabriela, Snijder, Berend, Sreedharan, Vipin T., Stark, Stefan, Stekhoven, Daniel J., Theocharides, Alexandre P.A., Thomas, Tinu M., Tosevski, Vinko, Toussaint, Nora C., Tuncel, Mustafa A., Tusup, Marina, Van Drogen, Audrey, Vetter, Marcus, Weber, Sandra, Wegmann, Rebekka, Weller, Michael, Wendt, Fabian, Wey, Norbert, Wicki, Andreas, Wildschut, Mattheus HE, Wollscheid, Bernd, Yu, Shuqing, Ziegler, Johanna, Zimmermann, Marc, Zuend, Gregor

“…CD8+ tumor-infiltrating T cells can be regarded as one of the most relevant predictive biomarkers in immune-oncology. Highly infiltrated tumors, referred to as…”
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Brain expression profiles of two SCN1A antisense RNAs in children and adolescents with epilepsy by Schneider, Marius Frederik, Vogt, Miriam, Scheuermann, Johanna, Müller, Veronika, Fischer-Hentrich, Antje H. L., Kremer, Thomas, Lugert, Sebastian, Metzger, Friedrich, Kudernatsch, Manfred, Kluger, Gerhard, Hartlieb, Till, Noachtar, Soheyl, Vollmar, Christian, Kunz, Mathias, Tonn, Jörg Christian, Coras, Roland, Blümcke, Ingmar, Pace, Claudia, Heinen, Florian, Klein, Christoph, Potschka, Heidrun, Borggraefe, Ingo

“…Heterozygous mutations within the voltage-gated sodium channel α subunit ( ) are responsible for the majority of cases of Dravet syndrome (DS), a severe…”
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Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging by Lugert, Sebastian, Basak, Onur, Knuckles, Philip, Haussler, Ute, Fabel, Klaus, Götz, Magdalena, Haas, Carola A., Kempermann, Gerd, Taylor, Verdon, Giachino, Claudio

“…New neurons are generated in the adult hippocampus throughout life by neural stem/progenitor cells (NSCs), and neurogenesis is a plastic process responsive to…”
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Role of adult hippocampal neurogenesis in cognition in physiology and disease: pharmacological targets and biomarkers by Costa, Veronica, Lugert, Sebastian, Jagasia, Ravi

“…Adult hippocampal neurogenesis is a remarkable form of brain structural plasticity by which new functional neurons are generated from adult neural stem…”
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The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support by Irmisch, Anja, Bonilla, Ximena, Chevrier, Stéphane, Lehmann, Kjong-Van, Singer, Franziska, Toussaint, Nora C., Esposito, Cinzia, Mena, Julien, Milani, Emanuela S., Casanova, Ruben, Stekhoven, Daniel J., Wegmann, Rebekka, Jacob, Francis, Sobottka, Bettina, Goetze, Sandra, Kuipers, Jack, Sarabia del Castillo, Jacobo, Tuncel, Mustafa A., Menzel, Ulrike, Jacobs, Andrea, Sivapatham, Sujana, Gut, Gabriele, Ficek, Joanna, Al-Quaddoomi, Faisal S., Albinus, Jonas, Alborelli, Ilaria, Attinger, Per-Olof, Baumhoer, Daniel, Beck-Schimmer, Beatrice, Bernasconi, Lara, Chicherova, Natalia, D'Costa, Maya, Danenberg, Esther, Erkens, Martin, Eschbach, Katja, Fedier, André, Ferreira, Pedro, Frey, Bruno, Grob, Linda, Günther, Detlef, Haberecker, Martina, Haeuptle, Pirmin, Herter, Sylvia, Holtackers, Rene, Jaeger, Tim M., Jahn, Katharina, James, Alva R., Jermann, Philip M., Kahles, André, Kahraman, Abdullah, Kunze, Christian P., Kurzeder, Christian, Lugert, Sebastian, Maass, Gerd, Markolin, Philipp, Metzler, Julian M., Murri, Riccardo, Ng, Charlotte K.Y., Nicolet, Stefan, Nowak, Marta, Piscuoglio, Salvatore, Ritter, Mathilde, Rommel, Christian, Rosano-González, María L., Santacroce, Natascha, Schwalie, Petra C., Schwan, Severin, Schär, Tobias, Senti, Gabriela, Sreedharan, Vipin T., Stark, Stefan, Thomas, Tinu M., Tosevski, Vinko, Tusup, Marina, Van Drogen, Audrey, Vetter, Marcus, Vlajnic, Tatjana, Weber, Sandra, Weber, Walter P., Weller, Michael, Wendt, Fabian, Wey, Norbert, Wildschut, Mattheus H.E., Yu, Shuqing, Ziegler, Johanna, Zimmermann, Marc, Zoche, Martin, Zuend, Gregor, Aebersold, Rudolf, Beerenwinkel, Niko, Beisel, Christian, Bodenmiller, Bernd, Heinzelmann-Schwarz, Viola, Koelzer, Viktor H., Moch, Holger, Pelkmans, Lucas, Theocharides, Alexandre P.A., Wicki, Andreas, Wollscheid, Bernd, Levesque, Mitchell P.

“…The application and integration of molecular profiling technologies create novel opportunities for personalized medicine. Here, we introduce the Tumor Profiler…”
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Neural Stem Cells: Disposable, End-State Glia? by Lugert, Sebastian, Taylor, Verdon

“…Neurogenesis in the brain diminishes with age. In this issue of Cell Stem Cell, Encinas et al. (2011) demonstrate that some hippocampal stem cells not only…”
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SCIM: universal single-cell matching with unpaired feature sets by Stark, Stefan G, Ficek, Joanna, Locatello, Francesco, Bonilla, Ximena, Chevrier, Stéphane, Singer, Franziska, Rätsch, Gunnar, Lehmann, Kjong-Van

“…Abstract Motivation Recent technological advances have led to an increase in the production and availability of single-cell data. The ability to integrate a…”
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Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1(high) intermediate progenitors by Lugert, Sebastian, Vogt, Miriam, Tchorz, Jan S, Müller, Matthias, Giachino, Claudio, Taylor, Verdon

“…Neural stem/progenitor cells generate neurons in the adult hippocampus. Neural stem cells produce transient intermediate progenitors (type-2 cells), which…”
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Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs by Knuckles, Philip, Vogt, Miriam A, Lugert, Sebastian, Milo, Marta, Chong, Mark M W, Hautbergue, Guillaume M, Wilson, Stuart A, Littman, Dan R, Taylor, Verdon

“…Temporal regulation of embryonic neurogenesis is controlled by hypostable transcription factors. Here the authors show that the RNase III Drosha and…”
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Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer by Dondi, Arthur, Lischetti, Ulrike, Jacob, Francis, Singer, Franziska, Borgsmüller, Nico, Coelho, Ricardo, Heinzelmann-Schwarz, Viola, Beisel, Christian, Beerenwinkel, Niko

“…Understanding the complex background of cancer requires genotype-phenotype information in single-cell resolution. Here, we perform long-read single-cell RNA…”
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Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia by Wegmann, Rebekka, Bonilla, Ximena, Casanova, Ruben, Chevrier, Stéphane, Coelho, Ricardo, Esposito, Cinzia, Ficek-Pascual, Joanna, Goetze, Sandra, Gut, Gabriele, Jacob, Francis, Jacobs, Andrea, Kuipers, Jack, Lischetti, Ulrike, Mena, Julien, Milani, Emanuela S., Prummer, Michael, Del Castillo, Jacobo Sarabia, Singer, Franziska, Sivapatham, Sujana, Toussaint, Nora C., Vilinovszki, Oliver, Wildschut, Mattheus H. E., Thavayogarajah, Tharshika, Malani, Disha, Aebersold, Rudolf, Bacac, Marina, Beerenwinkel, Niko, Beisel, Christian, Bodenmiller, Bernd, Heinzelmann-Schwarz, Viola, Koelzer, Viktor H., Levesque, Mitchell P., Moch, Holger, Pelkmans, Lucas, Rätsch, Gunnar, Tolnay, Markus, Wicki, Andreas, Wollscheid, Bernd, Manz, Markus G., Snijder, Berend, Theocharides, Alexandre P. A.

“…Deep single-cell multi-omic profiling offers a promising approach to understand and overcome drug resistance in relapsed or refractory (rr) acute myeloid…”
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Probabilistic pathway-based multimodal factor analysis by Immer, Alexander, Stark, Stefan G, Jacob, Francis, Bonilla, Ximena, Thomas, Tinu, Kahles, André, Goetze, Sandra, Milani, Emanuela S, Wollscheid, Bernd, Rätsch, Gunnar, Lehmann, Kjong-Van

“…Abstract Motivation Multimodal profiling strategies promise to produce more informative insights into biomedical cohorts via the integration of the information…”
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scAmpi-A versatile pipeline for single-cell RNA-seq analysis from basics to clinics by Bertolini, Anne, Prummer, Michael, Tuncel, Mustafa Anil, Menzel, Ulrike, Rosano-González, María Lourdes, Kuipers, Jack, Stekhoven, Daniel Johannes, Beerenwinkel, Niko, Singer, Franziska

“…Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful technique to decipher tissue composition at the single-cell level and to inform on disease…”
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Characterization of a human pluripotent stem cell-derived model of neuronal development using multiplexed targeted proteomics by Dunkley, Tom, Costa, Veronica, Friedlein, Arno, Lugert, Sebastian, Aigner, Stefan, Ebeling, Martin, Miller, Meghan T., Patsch, Christoph, Piraino, Paolo, Cutler, Paul, Jagasia, Ravi

“…Purpose Human pluripotent stem cell (hPSC)‐derived cellular models have great potential to enable drug discovery and improve translation of preclinical…”
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scROSHI: robust supervised hierarchical identification of single cells by Prummer, Michael, Bertolini, Anne, Bosshard, Lars, Barkmann, Florian, Yates, Josephine, Boeva, Valentina, Stekhoven, Daniel, Singer, Franziska

“…Abstract Identifying cell types based on expression profiles is a pillar of single cell analysis. Existing machine-learning methods identify predictive…”
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Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1high intermediate progenitors by Lugert, Sebastian, Vogt, Miriam, Tchorz, Jan S., Müller, Matthias, Giachino, Claudio, Taylor, Verdon

“…Neural stem/progenitor cells generate neurons in the adult hippocampus. Neural stem cells produce transient intermediate progenitors (type-2 cells), which…”
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14-P010 Notch signalling contributes to adult neurogenesis and regeneration of the neural progenitor pool by Giachino, Claudio, Basak, Onur, Lugert, Sebastian, Taylor, Verdon

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