Search Results - "Luger, Thomas"

Nanomedicine-Challenge and Perspectives by Riehemann, Kristina, Schneider, Stefan W., Luger, Thomas A., Godin, Biana, Ferrari, Mauro, Fuchs, Harald

“…The application of nanotechnology concepts to medicine joins two large cross‐disciplinary fields with an unprecedented societal and economical potential…”
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Targeting the neurokinin receptor 1 with aprepitant: a novel antipruritic strategy by Ständer, Sonja, Siepmann, Dorothee, Herrgott, Ilka, Sunderkötter, Cord, Luger, Thomas A

“…Chronic pruritus is a global clinical problem with a high impact on the quality of life and lack of specific therapies. It is an excruciating and frequent…”
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Atopic dermatitis: Role of the skin barrier, environment, microbiome, and therapeutic agents by Luger, Thomas, Amagai, Masayuki, Dreno, Brigitte, Dagnelie, Marie-Ange, Liao, Wilson, Kabashima, Kenji, Schikowski, Tamara, Proksch, Ehrhardt, Elias, Peter M., Simon, Michel, Simpson, Eric, Grinich, Erin, Schmuth, Matthias

“…•Impaired skin barrier function drives the pathophysiology of atopic dermatitis.•Defects in skin barrier component genes lead to impaired skin barrier…”
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Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder by Brunner, Patrick M., Silverberg, Jonathan I., Guttman-Yassky, Emma, Paller, Amy S., Kabashima, Kenji, Amagai, Masayuki, Luger, Thomas A., Deleuran, Mette, Werfel, Thomas, Eyerich, Kilian, Stingl, Georg, Bagot, Martine, Hijnen, Dirk Jan, Ardern-Jones, Michael, Reynolds, Nick, Spuls, Phyllis, Taieb, Alain

“…Atopic dermatitis comorbidities extend well beyond the march to allergic conditions (food allergy, asthma, allergic rhinitis, allergic conjunctivitis, and…”
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Serlopitant reduced pruritus in patients with prurigo nodularis in a phase 2, randomized, placebo-controlled trial by Ständer, Sonja, Kwon, Paul, Hirman, Joe, Perlman, Andrew J., Weisshaar, Elke, Metz, Martin, Luger, Thomas A.

“…Anecdotal evidence suggests that neurokinin 1 receptor antagonism reduces pruritus intensity in chronic pruritic conditions such as prurigo nodularis (PN)…”
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The skin in psoriasis: assessment and challenges by Oji, Vinzenz, Luger, Thomas A

“…The coexistence of psoriasis arthritis (PsA) and psoriasis vulgaris in about 20% of patients with psoriasis leads to a need for rheumatologic-dermatologic team…”
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Melatonin and Its Metabolites Ameliorate UVR-Induced Mitochondrial Oxidative Stress in Human MNT-1 Melanoma Cells by Kleszczyński, Konrad, Bilska, Bernadetta, Stegemann, Agatha, Flis, Damian Jozef, Ziolkowski, Wieslaw, Pyza, Elżbieta, Luger, Thomas A, Reiter, Russel J, Böhm, Markus, Slominski, Andrzej T

“…Melatonin (Mel) is the major biologically active molecule secreted by the pineal gland. Mel and its metabolites, 6-hydroxymelatonin (6(OH)Mel) and…”
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α-Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Antiinflammatory and Protective Effects in Vitro and in Vivo, and Future Perspectives for the Treatment of Immune-Mediated Inflammatory Diseases by Brzoska, Thomas, Luger, Thomas A, Maaser, Christian, Abels, Christoph, Böhm, Markus

“…α-MSH is a tridecapeptide derived from proopiomelanocortin. Many studies over the last few years have provided evidence that α-MSH has potent protective and…”
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An α-MSH Analog in Erythropoietic Protoporphyria by Luger, Thomas A., Böhm, Markus

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The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8 + T cells by Loser, Karin, Vogl, Thomas, Voskort, Maik, Lueken, Aloys, Kupas, Verena, Nacken, Wolfgang, Klenner, Lars, Kuhn, Annegret, Foell, Dirk, Sorokin, Lydia, Luger, Thomas A, Roth, Johannes, Beissert, Stefan

“…Mechanisms linking innate immunity and autoimmune responses are poorly understood. Myeloid-related protein-8 (Mrp8) and Mrp14 are damage-associated molecular…”
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A Synthetic Sandalwood Odorant Induces Wound-Healing Processes in Human Keratinocytes via the Olfactory Receptor OR2AT4 by Busse, Daniela, Kudella, Philipp, Grüning, Nana-Maria, Gisselmann, Günter, Ständer, Sonja, Luger, Thomas, Jacobsen, Frank, Steinsträßer, Lars, Paus, Ralf, Gkogkolou, Paraskevi, Böhm, Markus, Hatt, Hanns, Benecke, Heike

“…As the outermost barrier of the body, the skin is exposed to multiple environmental factors, including temperature, humidity, mechanical stress, and chemical…”
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Comparison of different skin care regimens in patients with moderate to severe atopic dermatitis receiving systemic treatment: A randomized controlled trial by Magnolo, Nina, Jaenicke, Thomas, Tsianakas, Athanasios, Czech, Wolfgang, Thaçi, Diamant, Pinter, Andreas, Kerob, Delphine, Salah, Samir, Luger, Thomas A.

“…Background Moderate to severe AD can be successfully managed by systemic treatments. Current guidelines also recommend emollients or emollients ‘plus’ and…”
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Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity by Breuer, Johanna, Schwab, Nicholas, Schneider-Hohendorf, Tilman, Marziniak, Martin, Mohan, Hema, Bhatia, Urvashi, Gross, Catharina C., Clausen, Björn E., Weishaupt, Carsten, Luger, Thomas A., Meuth, Sven G., Loser, Karin, Wiendl, Heinz

“…Objective Environmental conditions (eg, latitude) play a critical role in the susceptibility and severity of many autoimmune disorders, including multiple…”
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Serlopitant for the treatment of chronic pruritus: Results of a randomized, multicenter, placebo-controlled phase 2 clinical trial by Yosipovitch, Gil, Ständer, Sonja, Kerby, Matthew B., Larrick, James W., Perlman, Andrew J., Schnipper, Edward F., Zhang, Xiaoming, Tang, Jean Y., Luger, Thomas, Steinhoff, Martin

“…The substance P/neurokinin 1 receptor pathway is critical in chronic pruritus; anecdotal evidence suggests that antagonism of this pathway can reduce chronic…”
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Increased skin pH and transepidermal water loss may serve as predictor for atopic dermatitis flares by Marini, Alessandra, Aue, Natalie, Demessant, Anne‐Laure, Salah, Samir, Kerob, Delphine, Luger, Thomas A.

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Antipruritic treatment with systemic μ-opioid receptor antagonists: A review by Phan, Ngoc Quan, MD, Bernhard, Jeffrey D., MD, Luger, Thomas A., MD, Ständer, Sonja, MD

“…During the past two decades, systemic μ-opioid receptor antagonists (MORA) have been used in the treatment of various forms of chronic pruritus. In a number of…”
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Aprepitant in Anti-histamine-refractory Chronic Nodular Prurigo: A Multicentre, Randomized, Double-blind, Placebo-controlled, Cross-over, Phase-II trial (APREPRU) by Tsianakas, Athanasios, Zeidler, Claudia, Riepe, Claudia, Borowski, Matthias, Forner, Caroline, Gerss, Joachim, Metz, Martin, Staubach, Petra, Raap, Ulrike, Kaatz, Martin, Urban, Marc, Luger, Thomas A, Ständer, Sonja

“…The aim of this multicentre, randomized, double-blind, placebo-controlled, cross-over, phase-II study was to determine the antipruritic effect of aprepitant…”
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Clinical, cellular, and molecular aspects in the pathophysiology of rosacea by Steinhoff, Martin, Buddenkotte, Jörg, Aubert, Jerome, Sulk, Mathias, Novak, Pawel, Schwab, Verena D, Mess, Christian, Cevikbas, Ferda, Rivier, Michel, Carlavan, Isabelle, Déret, Sophie, Rosignoli, Carine, Metze, Dieter, Luger, Thomas A, Voegel, Johannes J

“…Rosacea is a chronic inflammatory skin disease of unknown etiology. Although described centuries ago, the pathophysiology of this disease is still poorly…”
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Proteinase-Activated Receptors: Transducers of Proteinase-Mediated Signaling in Inflammation and Immune Response by Steinhoff, Martin, Buddenkotte, Jörg, Shpacovitch, Victoria, Rattenholl, Anke, Moormann, Corinna, Vergnolle, Nathalie, Luger, Thomas A, Hollenberg, Morley D

“…Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example, are highly active mediators with diverse biological activities…”
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Impact of ixekizumab on psoriasis itch severity and other psoriasis symptoms: Results from 3 phase III psoriasis clinical trials by Kimball, Alexandra B., MD, MPH, Luger, Thomas, MD, PhD, Gottlieb, Alice, MD, PhD, Puig, Luis, MD, PhD, Kaufmann, Roland, MD, Nikaï, Enkeleida, MS Psy, Zhu, Baojin, PhD, Edson-Heredia, Emily, MPH, Carlier, Hilde, MD, Lin, Chen-Yen, PhD, Goldblum, Orin, MD, Yosipovitch, Gil, MD

“…Background Itch is a prevalent symptom of psoriasis that impacts quality of life. Objective We sought to describe improvements in itch severity, skin pain, and…”
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