Search Results - "Lugar, Patricia L."

Patterns of microRNA expression characterize stages of human B-cell differentiation by Zhang, Jenny, Jima, Dereje D., Jacobs, Cassandra, Fischer, Randy, Gottwein, Eva, Huang, Grace, Lugar, Patricia L., Lagoo, Anand S., Rizzieri, David A., Friedman, Daphne R., Weinberg, J. Brice, Lipsky, Peter E., Dave, Sandeep S.

“…Mature B-cell differentiation provides an important mechanism for the acquisition of adaptive immunity. Malignancies derived from mature B cells constitute the…”
Get full text

Penicillin Skin Testing to Evaluate Penicillin Allergy: Outcome of Testing Results Fails to Affect Clinical Practice by Kleris, Renee, MD, Lugar, Patricia L., MD, MS

“…A number of unexpected findings included infrequent use of penicillin/derivative medications after negative testing, discrepancies between pediatric and adult…”
Get full text

Peri-operative Anaphylaxis: Evaluation and Management for Outpatient Testing by Lugar, Patricia L., MD, MS, Kleris, Renee, MD

“…Rationale Beyond acute management, the challenge of evaluating peri-operative anaphylaxis rests not only on number of possible exposures but also designing…”
Get full text

Molecular characterization of circulating plasma cells in patients with active systemic lupus erythematosus by Lugar, Patricia L, Love, Cassandra, Grammer, Amrie C, Dave, Sandeep S, Lipsky, Peter E

“…Systemic lupus erythematosus (SLE) is a generalized autoimmune disease characterized by abnormal B cell activation and the occurrence of increased frequencies…”
Get full text

The Significance of Anti-Fc Epsilon RI Antibodies in Chronic Idiopathic Urticaria: The Role of Autoimmunity in the Differential Response to Treatment by Kim-Chang, Julie J., MD, Lugar, Patricia L., MD, MS, Keswani, Anjeni, MD, MSCI

“…Methods A retrospective review of electronic health records of patients aged >=12 years with CIU evaluated for anti-Fc[varepsilon]RI antibodies was conducted…”
Get full text

An Unusual Presentation of Cutaneous Leukocytoclastic Vasculitis to Subcutaneous but Not IV Insulin in a Patient with Common Variable Immunodeficiency (CVID), Type I DM (T1D), and Autoimmune Enteropathy (AIE) by Kim-Chang, Julie J., MD, Lugar, Patricia L., MD MS

“…Results A 23 year old female with a history of CVID, T1D and AIE presented with a 2-week history of localized skin reactions to subcutaneous insulin (both…”
Get full text

Diagnostic Immunization With Bacteriophage ΦX 174 In Patients With Common Variable Immunodeficiency/Hypogammaglobulinemia by Smith, Lauren, Dr, Buckley, Rebecca H., Dr, Lugar, Patricia L., Dr

Get full text

Interrogating Genetic Susceptibility Loci in CVID and Autoimmunity by Yang, Luanna, Shah, Shaili N., MD, Serafin, D Stephen, Timoshchenko, Roman G, Scotland, Paula, Richards, Kristy, Billard, Matthew J, Lugar, Patricia L., MD, MS, Tarrant, Teresa K., MD, FAAAAI

“…[...]we hypothesized that possessing the allele may correlate with decreased autoimmunity in CVID…”
Get full text

Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting by Longo, Nancy S., Lugar, Patricia L., Yavuz, Sule, Zhang, Wen, Krijger, Peter H.L., Russ, Daniel E., Jima, Dereje D., Dave, Sandeep S., Grammer, Amrie C., Lipsky, Peter E.

“…Subjects with X-linked hyper-IgM syndrome (X-HIgM) have a markedly reduced frequency of CD27+ memory B cells, and their Ig genes have a low level of somatic…”
Get full text

The genetic landscape of mutations in Burkitt lymphoma by Love, Cassandra, Sun, Zhen, Jima, Dereje, Li, Guojie, Zhang, Jenny, Miles, Rodney, Richards, Kristy L, Dunphy, Cherie H, Choi, William W L, Srivastava, Gopesh, Lugar, Patricia L, Rizzieri, David A, Lagoo, Anand S, Bernal-Mizrachi, Leon, Mann, Karen P, Flowers, Christopher R, Naresh, Kikkeri N, Evens, Andrew M, Chadburn, Amy, Gordon, Leo I, Czader, Magdalena B, Gill, Javed I, Hsi, Eric D, Greenough, Adrienne, Moffitt, Andrea B, McKinney, Matthew, Banerjee, Anjishnu, Grubor, Vladimir, Levy, Shawn, Dunson, David B, Dave, Sandeep S

“…Sandeep Dave and colleagues report exome sequencing of 59 Burkitt lymphomas. They report recurrent mutations in many genes, including ID3 , MYC , GNA13 , RET ,…”
Get full text

Genetic heterogeneity of diffuse large B-cell lymphoma by Zhang, Jenny, Grubor, Vladimir, Love, Cassandra L., Banerjee, Anjishnu, Richards, Kristy L., Mieczkowski, Piotr A., Dunphy, Cherie, Choi, William, Au, Wing Yan, Srivastava, Gopesh, Lugar, Patricia L, Rizzieri, David A., Lagoo, Anand S., Bernal-Mizrachi, Leon, Mann, Karen P., Flowers, Christopher, Naresh, Kikkeri, Evens, Andrew, Gordon, Leo I., Czader, Magdalena, Gill, Javed I., Hsi, Eric D., Liu, Qingquan, Fan, Alice, Walsh, Katherine, Jima, Dereje, Smith, Lisa L., Johnson, Amy J., Byrd, John C., Luftig, Micah A., Ni, Ting, Zhu, Jun, Chadburn, Amy, Levy, Shawn, Dunson, David, Dave, Sandeep S.

“…Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma in adults. The disease exhibits a striking heterogeneity in gene expression profiles…”
Get full text

Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2 by Moffitt, Andrea B, Ondrejka, Sarah L, McKinney, Matthew, Rempel, Rachel E, Goodlad, John R, Teh, Chun Huat, Leppa, Sirpa, Mannisto, Susanna, Kovanen, Panu E, Tse, Eric, Au-Yeung, Rex K H, Kwong, Yok-Lam, Srivastava, Gopesh, Iqbal, Javeed, Yu, Jiayu, Naresh, Kikkeri, Villa, Diego, Gascoyne, Randy D, Said, Jonathan, Czader, Magdalena B, Chadburn, Amy, Richards, Kristy L, Rajagopalan, Deepthi, Davis, Nicholas S, Smith, Eileen C, Palus, Brooke C, Tzeng, Tiffany J, Healy, Jane A, Lugar, Patricia L, Datta, Jyotishka, Love, Cassandra, Levy, Shawn, Dunson, David B, Zhuang, Yuan, Hsi, Eric D, Dave, Sandeep S

“…Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic…”
Get full text

Diagnostic interpretation of genetic studies in patients with primary immunodeficiency diseases: A working group report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma & Immunology by Chinn, Ivan K., Chan, Alice Y., Chen, Karin, Chou, Janet, Dorsey, Morna J., Hajjar, Joud, Jongco, Artemio M., Keller, Michael D., Kobrynski, Lisa J., Kumanovics, Attila, Lawrence, Monica G., Leiding, Jennifer W., Lugar, Patricia L., Orange, Jordan S., Patel, Kiran, Platt, Craig D., Puck, Jennifer M., Raje, Nikita, Romberg, Neil, Slack, Maria A., Sullivan, Kathleen E., Tarrant, Teresa K., Torgerson, Troy R., Walter, Jolan E.

“…Genetic testing has become an integral component of the diagnostic evaluation of patients with suspected primary immunodeficiency diseases. Results of genetic…”
Get full text

Inpatient Penicillin Allergy Evaluation Program Enriches Anti-Microbial Stewardship Aims by Kleris, Renee, Sarubbi, Christina, Wrenn, Rebekah, Anderson, Deverick, Lugar, Patricia L.

“…Rationale The stewardship allergy assessment team (StAAT) consists of representation from pharmacy, infectious disease, and allergy who offer penicillin skin…”
Get full text

Characterization of pediatric onset common variable immunodeficiency (CVID) in a large cohort by Baloh, Carolyn H., Reddy, Anupama, Buckley, Rebecca H., Lugar, Patricia L.

“…Rationale Pediatric-onset CVID is poorly characterized with a sparse number of dedicated reports that lack longitudinal follow-up to allow for understanding…”
Get full text

A study of cancer incidence in the most common immunodeficiency, common variable immunodeficiency (CVID) by Baloh, Carolyn H., Henson, Michele R., Reddy, Anupama, Buckley, Rebecca H., Lugar, Patricia L.

Get full text

Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs by Jima, Dereje D., Zhang, Jenny, Jacobs, Cassandra, Richards, Kristy L., Dunphy, Cherie H., Choi, William W.L., Yan Au, Wing, Srivastava, Gopesh, Czader, Magdalena B., Rizzieri, David A., Lagoo, Anand S., Lugar, Patricia L., Mann, Karen P., Flowers, Christopher R., Bernal-Mizrachi, Leon, Naresh, Kikkeri N., Evens, Andrew M., Gordon, Leo I., Luftig, Micah, Friedman, Daphne R., Weinberg, J. Brice, Thompson, Michael A., Gill, Javed I., Liu, Qingquan, How, Tam, Grubor, Vladimir, Gao, Yuan, Patel, Amee, Wu, Han, Zhu, Jun, Blobe, Gerard C., Lipsky, Peter E., Chadburn, Amy, Dave, Sandeep S.

“…A role for microRNA (miRNA) has been recognized in nearly every biologic system examined thus far. A complete delineation of their role must be preceded by the…”
Get full text

Things We Do For No Reason™: Failing to Question a Penicillin Allergy History by Kleris, Renee S, Lugar, Patricia L

“…Inspired by the ABIM Foundation's Choosing Wisely® campaign, the “Things We Do for No Reason™” (TWDFNR) series reviews practices that have become common parts…”
Get full text

Pricking away at penicillin allergy with a dedicated outpatient clinic by Kleris, Renee, Tang, Monica, Radojicic, Cristine, Lugar, Patricia L.

“…Penicillin (PCN) drug allergy is the most common antibiotic allergy reported by 7% to 10% of the adult US population and 15% to 20% of inpatients.1,2 Despite…”
Get full text

Low Serum IgE Is a Sensitive and Specific Marker for Common Variable Immunodeficiency (CVID) by Lawrence, Monica G., Palacios-Kibler, Thamiris V., Workman, Lisa J., Schuyler, Alexander J., Steinke, John W., Payne, Spencer C., McGowan, Emily C., Patrie, James, Fuleihan, Ramsay L., Sullivan, Kathleen E., Lugar, Patricia L., Hernandez, Camellia L., Beakes, Douglas E., Verbsky, James W., Platts-Mills, Thomas A. E., Cunningham-Rundles, Charlotte, Routes, John M., Borish, Larry

“…Although small prior studies have suggested that IgE can be low in common variable immunodeficiency (CVID), the workup for patients with recurrent infections…”
Get full text