Search Results - "Luetjens, C. Marc"

Complete Spermatogenesis in Orthotopic But Not in Ectopic Transplants of Autologously Grafted Marmoset Testicular Tissue by Marc Luetjens, C, Stukenborg, Jan-Bernd, Nieschlag, Eberhard, Simoni, Manuela, Wistuba, Joachim

“…Testicular grafting has the potential to become a method to preserve fertility in prepubertal boys undergoing cancer treatment. The possibility of successful…”
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Primate spermatogenesis: new insights into comparative testicular organisation, spermatogenic efficiency and endocrine control by Marc Luetjens, C., Weinbauer, Gerhard F., Wistuba, Joachim

“…Owing to the close phylogenetic relationship of Platyrrhini (New World monkeys) and Catarrhini (Old World monkeys) to man, nonhuman primates are often used as…”
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Male 41, XXY Mice as a Model for Klinefelter Syndrome: Hyperactivation of Leydig Cells by Wistuba, Joachim, Luetjens, C. Marc, Stukenborg, Jan-Bernd, Poplinski, Andreas, Werler, Steffi, Dittmann, Matthias, Damm, Oliver S, Hämäläinen, Tuula, Simoni, Manuela, Gromoll, Jörg

“…Sex chromosome imbalance in males is linked to a supernumerary X chromosome, a condition resulting in Klinefelter syndrome (KS; 47, XXY). KS patients suffer…”
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Group size experiences with enhanced pre- and postnatal development studies in the long-tailed macaque ( Macaca fascicularis ) by Luetjens, C Marc, Fuchs, Antje, Baker, Ann, Weinbauer, Gerhard F

“…Enhanced pre- and postnatal development (ePPND) studies have become the default developmental toxicity test for biopharmaceuticals if nonhuman primates…”
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Activation of Calpain I Converts Excitotoxic Neuron Death into a Caspase-independent Cell Death by Lankiewicz, Silke, Marc Luetjens, C., Truc Bui, Nguyen, Krohn, Aaron J., Poppe, Monika, Cole, Greg M., Saido, Takaomi C., Prehn, Jochen H.M.

“…Glutamate receptor overactivation contributes to neuron death after stroke, trauma, and epileptic seizures. Exposure of cultured rat hippocampal neurons to the…”
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Coculture of Spermatogonia With Somatic Cells in a Novel Three-Dimensional Soft-Agar-Culture-System by Stukenborg, Jan-Bernd, Wistuba, Joachim, Luetjens, C. Marc, Elhija, Mahmoud Abu, Huleihel, Mahmoud, Lunenfeld, Eitan, Gromoll, Jorg, Nieschlag, Eberhard, Schlatt, Stefan

“…Isolation and culture of spermatogonial stem cells (SSCs) has become an approach to study the milieu and the factors controlling their expansion and…”
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Chorionic Gonadotropin β-Subunit Gene Expression in the Marmoset Pituitary Is Controlled by Steroidogenic Factor 1, Early Growth Response Protein 1, and Pituitary Homeobox Factor 1 by Henke, Alexander, Marc Luetjens, C, Simoni, Manuela, Gromoll, Jörg

“…In most mammals, the gonads are under the control of the pituitary gonadotropins LH and FSH. However, in the common marmoset monkey Callithrix jacchus, no LH…”
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Deep Learning–Based Spermatogenic Staging in Tissue Sections of Cynomolgus Macaque Testes by Mecklenburg, Lars, Luetjens, C. Marc, Romeike, Annette, Garg, Rohit, Samanta, Pranab, Mohanty, Amogh, Thomas, Tijo, Weinbauer, Gerhard

“…The indirect assessment of adverse effects on fertility in cynomolgus monkeys requires that tissue sections of the testis be microscopically evaluated with…”
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Intravitreal RTH258 (brolucizumab) demonstrates no effect on pregnancy, parturition, embryofetal or postnatal development in cynomolgus monkeys by Booler, Helen, DeLise, Anthony M., Nimz, Erik, Shefchek, Diana, Luetjens, C. Marc

“…RTH258 (brolucizumab) is a humanized single chain antibody fragment, the smallest functional unit of an antibody designed to target vascular endothelial growth…”
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Male congenital hypothyroid Pax8−/− mice are infertile despite adequate treatment with thyroid hormone by Wistuba, Joachim, Mittag, Jens, Luetjens, C Marc, Cooper, Trevor G, Yeung, Ching-Hei, Nieschlag, Eberhard, Bauer, Karl

“…Severe forms of congenital hypothyroidism lead to serious clinical symptoms if thyroid hormone replacement therapy is not instituted immediately after birth…”
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Tissue expression of the nuclear progesterone receptor in male non-human primates and men by Luetjens, C Marc, Didolkar, Aditya, Kliesch, Sabine, Paulus, Werner, Jeibmann, Astrid, Böcker, Werner, Nieschlag, Eberhard, Simoni, Manuela

“…In females, progesterone is associated with reproductive functions. In males, its role and the expression of its genomic receptor are not very well understood…”
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CoGrafting of Hamster (Phodopus sungorus) and Marmoset (Callithrix jacchus) Testicular Tissues into Nude Mice Does Not Overcome Blockade of Early Spermatogenic Differentiation in Primate Grafts by WISTUBA, Joachim, MUNDRY, Marvin, LUETJENS, C. Marc, SCHLATT, Stefan

“…The ectopic xenotransplantation of testicular tissues into nude mice is a tool to generate sperm from immature testes. Immunodeficient mice as recipients of…”
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Organization of Seminiferous Epithelium in Primates: Relationship to Spermatogenic Efficiency, Phylogeny, and Mating System by WISTUBA, Joachim, SCHROD, Annette, GREVE, Burkhard, HODGES, J. Keith, ASLAM, Humaira, WEINBAUER, Gerhard F, LUETJENS, C. Marc

“…The succession in time and space of specific germ cell associations, denoted as spermatogenic stages, is a typical feature of mammalian spermatogenesis. The…”
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Toxicologic Pathology Forum: Opinion on Sexual Maturity and Fertility Assessment in Long-tailed Macaques (Macaca fascicularis) in Nonclinical Safety Studies by Mecklenburg, Lars, Luetjens, C. Marc, Weinbauer, Gerhard F.

“…If nonhuman primates represent the only relevant species for nonclinical safety evaluation of biotechnology-derived products, male and female fertility effects…”
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Meiosis in Autologous Ectopic Transplants of Immature Testicular Tissue Grafted to Callithrix jacchus by WISTUBA, Joachim, LUETJENS, C. Marc, WESSELMANN, Ramona, NIESCHLAG, Eberhard, SIMONI, Manuela, SCHLATT, Stefan

“…Grafting of immature testicular tissue provides a tool to examine testicular development and may offer a perspective for preservation of fertility in…”
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Enhanced normograms and pregnancy outcome analysis in nonhuman primate developmental toxicity studies by Grossmann, Heiko, Weinbauer, Gerhard F., Baker, Ann, Fuchs, Antje, Luetjens, C. Marc

“…•Assess and benchmark pregnancy outcome data; of regulatory ICH driven DART studies.•New concept of separate normograms through statistical analysis.•Enhanced…”
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Enhanced Prenatal and Postnatal Development Study in Marmoset Monkeys Following Administration of Felzartamab by Mangelberger-Eberl, Doris, Cosenza, Mary Ellen, Härtle, Stefan, Luetjens, C. Marc, Welsh, Brian T., Steidl, Stefan, Flesher, Donna L., Chinn, Leslie W.

“…Felzartamab is a recombinant fully human immunoglobulin G1 anti-CD38 monoclonal antibody under clinical investigation for immune-mediated diseases. In support…”
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Optimising workflow in andrology： a new electronic patient record and database by Tüttelmann, Frank, Luetjens, C. Marc, Nieschlag, Eberhard

“…Aim： To improve workflow and usability by introduction of a new electronic patient record （EPR） and database. Methods： Establishment of an EPR based on open…”
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Effect of ofatumumab on pregnancy, parturition, and lactation in cynomolgus monkeys by Bellot, Muriel, Luetjens, C. Marc, Bagger, Morten, Horvath, Courtney, Sutter, Esther, DeLise, Anthony, Brees, Dominique, Carballido, José M., Pingili, Ratnakar, Ramanathan, Krishnan, Kieseier, Bernd C., Hellwig, Kerstin

“…•Drugs are tested in pregnant monkeys and offspring to check for their safety in people.•Ofatumumab is a treatment for people with multiple…”
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GnRH-antagonist mediated down-regulation of the estrous cycle in marmosets by Marc Luetjens, C., Wesselmann, Ramona, Kuhlmann, Michael

“…Background  Because of its small size and unproblematic captivity behavior the marmoset monkey is an attractive New World primate model for early developmental…”
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