Search Results - "Lues, I."

In pursuit of a sensitive EEG functional connectivity outcome measure for clinical trials in Alzheimer’s disease by Briels, C.T., Stam, C.J., Scheltens, P., Bruins, S., Lues, I., Gouw, A.A.

“…•Aim was to find a sensitive functional connectivity measure for trials in Alzheimer's disease (AD).•The functional connectivity measures phase lag index (PLI)…”
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14 Inhibition of glutaminyl cyclase targeting neurodegeneration and neuroinflammation in Alzheimer's disease by Demuth, Hans-Ulrich, Schilling, S, Cynis, H, Heiser, U, Manhart, S, Graubner, S, Alexandru, A, Jagla, W, Lues, I, Weber, F, Glund, K

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Therapeutic potential of potassium channel activators in coronary heart disease by Haeusler, G, Lues, I

“…Potassium channel activators have the ability to open potassium channels in a variety of cells. Since most of their effects are antagonized by antidiabetic…”
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Involvement of ATP-sensitive potassium channels in preconditioning protection by ROHMANN, S, WEYGANDT, H, SCHELLING, P, KIE SOEI, L, VERDOUW, P. D, LUES, I

“…Single or multiple brief periods of ischemia (preconditioning, PC) have been shown to protect the myocardium from infarction during a subsequent more prolonged…”
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EMD 53998 acts as Ca(2+)-sensitizer and phosphodiesterase III-inhibitor in human myocardium by Uhlmann, R, Schwinger, R H, Lues, I, Erdmann, E

“…The effect of EMD 53998 (EMD) (0.1-100 mumol/l), chemically a racemic thiadiazinone derivative, suggested to be a potent Ca(2+)-sensitizer, was studied in…”
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Effect of bimakalim (EMD 52692), an opener of ATP sensitive potassium channels, on infarct size, coronary blood flow, regional wall function, and oxygen consumption in swine by Rohmann, S, Weygandt, H, Schelling, P, Soei, L K, Becker, K H, Verdouw, P D, Lues, I, Häusler, G

“…The aim was to assess whether bimakalim, an opener of ATP sensitive potassium channels, can reduce infarct size in swine myocardium. Experiments were performed…”
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EMD 53998 acts as Ca2+-sensitizer and phosphodiesterase III-inhibitor in human myocardium by UHLMANN, R, SCHWINGER, R. H. G, LUES, I, ERDMANN, E

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Novel Diazinone Derivatives Separate Myofilament Ca2+ Sensitization and Phosphodiesterase III Inhibitory Effects in Guinea Pig Myocardium by Ventura, Carlo, Miller, Redonda, Wolf, Hans-Peter, Beier, Norbert, Jonas, Rochus, Klockow, Michael, Lues, Inge, Hano, Osamu, Spurgeon, Harold A, Lakatta, Edward G, Capogrossi, Maurizio C

“…The inotropic state of the myocardium can be enhanced via an increase in cell Ca loading or in myofilament responsiveness to Ca. Although different…”
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Central and peripheral actions of the novel κ‐opioid receptor agonist, EMD 60400 by Barber, A., Bartoszyk, G.D., Greiner, H.E., Mauler, F., Murray, R.D., Seyfried, C.A., Simon, M., Gottschlich, R., Harting, J., Lues, I.

“…1 The pharmacological characteristics of the κ‐opioid receptor agonist, EMD 60400, have been investigated, with particular reference to its central and…”
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Pharmacological basis for antihypertensive therapy with a novel dopamine agonist by Haeusler, G, Lues, I, Minck, K O, Schelling, P, Seyfried, C A

“…In the past, nearly all major mechanisms involved in the regulation of blood pressure have become targets of antihypertensive drugs. They include the brain…”
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Characterization of a novel K+ channel activator, EMD 52962, in electrophysiological and pharmacological experiments by De Peyer, J E, Lues, I, Gericke, R, Häusler, G

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3-Methyl-2H-1-benzopyran potassium channel activators by Gericke, Rolf, Harting, Juergen, Lues, Inge, Schittenhelm, Christine

“…By aldol condensation of 4-chromanones with paraformaldehyde, 3-alkylenechromanones 10 were obtained which gave 3-alkylchromenes following reduction and…”
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Genomics and CNS at Merck KGaA: first year evaluation; goals and prospects by den Daas, I., Seyfried, C.A., Schmitges, C.J., Lues, I.

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The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers by Lues, I, Beier, N, Jonas, R, Klockow, M, Haeusler, G

“…The novel cardiotonic EMD 53,998 increases contractile force in vitro through both inhibition of phosphodiesterase III (PDE III) activity and increase in the…”
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A new cardiotonic drug reduces the energy cost of active tension in cardiac muscle by Gross, T, Lues, I, Daut, J

“…The novel thiadiazinone EMD 57033 (EMD) increases the calcium responsiveness of the contractile proteins in cardiac muscle. In skinned ventricular trabeculae…”
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Three Thiadiazinone Derivatives, EMD 60417, EMD 66430, and EMD 66398, with Class III Antiarrhythmic Activity but Different Electrophysiologic Profiles by M. Himmel, Herbert, Wettwer, Erich, Lues, Inge, Beier, Norbert, Jonas, Rochus, Ravens, Ursula

“…The thiadiazinone derivatives EMD 60417, EMD 66430, and EMD 66398 were developed as class III antiarrhythmic agents. Their chemical structure is closely…”
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Calcium sensitization as a positive inotropic mechanism in diseased rat and human heart by Nankervis, R, Lues, I, Brown, L

“…The two isomers of the positive inotropic compound EMD 53998, (+)EMD 57033 and (-)EMD 57439, possess selective calcium sensitizing and phosphodiesterase (PDE)…”
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The novel cardiotonic agent EMD 53 998 is a potent "calcium sensitizer" by Beier, N, Harting, J, Jonas, R, Klockow, M, Lues, I, Haeusler, G

“…EMD 53 998, a novel thiadiazinone derivative, increases the contractile force of cardiac tissue in vitro through both an inhibition of phosphodiesterase III…”
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In vivo evidence of positive inotropism of EMD 57033 through calcium sensitization by Haeusler, G, Jonas, R, Minck, K O, Schliep, H J, Schelling, P, Weygandt, H, Lues, I

“…The previous separation of the racemic cardiotonic thiadiazinone derivative EMD 53998 yielded two enantiomers with different pharmacologic properties: EMD…”
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Non-Peptide Angiotensin II Receptor Antagonists: Synthesis and Biological Activity of a Series of Novel 4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridine Derivatives by Mederski, Werner W. K. R, Dorsch, Dieter, Bokel, Heinz-Hermann, Beier, Norbert, Lues, Ingeborg, Schelling, Pierre

“…A series of novel non-peptide angiotensin II receptor antagonists containing a 2,3,5-trisubstituted 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine was prepared…”
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