Search Results - "Luers, Georg"

Rat liver peroxisomes after fibrate treatment. A survey using quantitative mass spectrometry by Islinger, Markus, Lüers, Georg H, Li, Ka Wan, Loos, Maarten, Völkl, Alfred

“…Fibrates are known to induce peroxisome proliferation and the expression of peroxisomal beta-oxidation enzymes. To analyze fibrate-induced changes of complex…”
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A defect in the peroxisomal biogenesis in germ cells induces a spermatogenic arrest at the round spermatid stage in mice by Brauns, Ann-Kristin, Heine, Markus, Tödter, Klaus, Baumgart-Vogt, Eveline, Lüers, Georg H., Schumacher, Udo

“…Peroxisomes are involved in the degradation of very long-chain fatty acids (VLCFAs) by β -oxidation. Besides neurological defects, peroxisomal dysfunction can…”
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High interstitial fluid pressure is associated with low tumour penetration of diagnostic monoclonal antibodies applied for molecular imaging purposes by Heine, Markus, Freund, Barbara, Nielsen, Peter, Jung, Caroline, Reimer, Rudolph, Hohenberg, Heinrich, Zangemeister-Wittke, Uwe, Wester, Hans-Juergen, Lüers, Georg H, Schumacher, Udo

“…The human epithelial cell adhesion molecule (EpCAM) is highly expressed in a variety of clinical tumour entities. Although an antibody against EpCAM has…”
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TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network by Korrodi-Gregório, Luís, Vieira, Sandra I, Esteves, Sara L C, Silva, Joana V, Freitas, Maria João, Brauns, Ann-Kristin, Luers, Georg, Abrantes, Joana, Esteves, Pedro J, da Cruz E Silva, Odete A B, Fardilha, Margarida, da Cruz E Silva, Edgar F

“…Reversible phosphorylation plays an important role as a mechanism of intracellular control in eukaryotes. PPP1, a major eukaryotic Ser/Thr-protein phosphatase,…”
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Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1 by Koch, Annett, Schneider, Gabriele, Lüers, Georg H, Schrader, Michael

“…The mammalian dynamin-like protein DLP1 belongs to the dynamin family of large GTPases, which have been implicated in tubulation and fission events of cellular…”
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Hitchhiking of Cu/Zn Superoxide Dismutase to Peroxisomes - Evidence for a Natural Piggyback Import Mechanism in Mammals by Islinger, Markus, Li, Ka Wan, Seitz, Jürgen, Völkl, Alfred, Lüers, Georg H

“…Most newly synthesized peroxisomal proteins are imported in a receptor-mediated fashion, depending on the interaction of a peroxisomal targeting signal (PTS)…”
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Teaching interprofessional collaboration among future healthcare professionals by Kauff, Mathias, Bührmann, Thorsten, Gölz, Friederike, Simon, Liane, Lüers, Georg, van Kampen, Simone, Kraus de Camargo, Olaf, Snyman, Stefanus, Wulfhorst, Britta

“…Healthcare has become more complex in recent years. Such complexity can best be addressed by interprofessional teams. We argue that to ensure successful…”
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CEACAM1 promotes melanoma metastasis and is involved in the regulation of the EMT associated gene network in melanoma cells by Wicklein, Daniel, Otto, Benjamin, Suling, Anna, Elies, Eva, Lüers, Georg, Lange, Tobias, Feldhaus, Susanne, Maar, Hanna, Schröder-Schwarz, Jennifer, Brunner, Georg, Wagener, Christoph, Schumacher, Udo

“…We investigated the functional role of CEACAM1 in a spontaneous metastasis xenograft model of human melanoma in scid mice using BRAF wildtype MeWo cells with…”
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Cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathways by Xiao, Yu, Karnati, Srikanth, Qian, Guofeng, Nenicu, Anca, Fan, Wei, Tchatalbachev, Svetlin, Höland, Anita, Hossain, Hamid, Guillou, Florian, Lüers, Georg H, Baumgart-Vogt, Eveline

“…Cre-mediated excision of loxP sites is widely used in mice to manipulate gene function in a tissue-specific manner. To analyze phenotypic alterations related…”
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Selectins mediate small cell lung cancer systemic metastasis by Heidemann, Franziska, Schildt, Anna, Schmid, Katharina, Bruns, Oliver T, Riecken, Kristoffer, Jung, Caroline, Ittrich, Harald, Wicklein, Daniel, Reimer, Rudolph, Fehse, Boris, Heeren, Joerg, Lüers, Georg, Schumacher, Udo, Heine, Markus

“…Metastasis formation is the major reason for the extremely poor prognosis in small cell lung cancer (SCLC) patients. The molecular interaction partners…”
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Antibody directed against human YKL-40 increases tumor volume in a human melanoma xenograft model in scid mice by Salamon, Johannes, Hoffmann, Tatjana, Elies, Eva, Peldschus, Kersten, Johansen, Julia S, Lüers, Georg, Schumacher, Udo, Wicklein, Daniel

“…Induced overexpression of the secretory protein YKL-40 promotes tumor growth in xenograft experiments. We investigated if targeting YKL-40 with a monoclonal…”
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Peroxisomes in Human and Mouse Testis: Differential Expression of Peroxisomal Proteins in Germ Cells and Distinct Somatic Cell Types of the Testis by Nenicu, Anca, Lüers, Georg H, Kovacs, Werner, Bergmann, Martin, Baumgart-Vogt, Eveline

“…The vital importance of peroxisomal metabolism for regular function of the testis is stressed by the severe spermatogenesis defects induced by peroxisomal…”
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Reduced numbers of Sertoli, germ, and spermatogonial stem cells in impaired spermatogenesis by Hentrich, Anna, Wolter, Martin, Szardening-Kirchner, Carolin, Lüers, Georg H, Bergmann, Martin, Kliesch, Sabine, Konrad, Lutz

“…A key step in the investigation of male infertility is the appropriate classification of impaired spermatogenesis. In this study, we precisely identified…”
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Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression by Neumann-Giesen, Carolin, Falkenbach, Bianca, Beicht, Peter, Claasen, Stephanie, Lüers, Georg, Stuermer, Claudia A O, Herzog, Volker, Tikkanen, Ritva

“…The reggie protein family consists of two proteins, reggie-1 and -2, also called flotillins, which are highly ubiquitous and evolutionarily conserved. Both…”
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Indication for differential sorting of the rat v-SNARE splice isoforms VAMP-1a and -1b by Rodepeter, Fiona R, Wiegand, Susanne, Lüers, Hans-Georg, Bonaterra, Gabriel A, Lowe, Anson W, Bette, Michael, Jacob, Ralf, Mandic, Robert

“…Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins are essential constituents of the intracellular trafficking machinery…”
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Transient Complex Interactions of Mammalian Peroxisomes Without Exchange of Matrix or Membrane Marker Proteins by Bonekamp, Nina A., Sampaio, Paula, Abreu, Fernão Vistulo, Lüers, Georg H., Schrader, Michael

“…Peroxisomes and mitochondria show a much closer interrelationship than previously anticipated. They co‐operate in the metabolism of fatty acids and reactive…”
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Germ cells of male mice express genes for peroxisomal metabolic pathways implicated in the regulation of spermatogenesis and the protection against oxidative stress by Dastig, Sandra, Nenicu, Anca, Otte, David M., Zimmer, Andreas, Seitz, Jürgen, Baumgart-Vogt, Eveline, Lüers, Georg H.

“…Peroxisomes are organelles with main functions in the metabolism of lipids and of reactive oxygen species. Within the testis, they have different functional…”
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Insights into the membrane proteome of rat liver peroxisomes: Microsomal glutathione-S-transferase is shared by both subcellular compartments by Islinger, Markus, Lüers, Georg H., Zischka, Hans, Ueffing, Marius, Völkl, Alfred

“…Peroxisomes are ubiquitous “multipurpose” organelles of eukaryotic cells. Their matrix enzymes catalyze mainly catabolic and anabolic reactions of lipid…”
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Peroxisomes in Human and Mouse Testis: Differential Expression of Peroxisomal Proteins in Germ Cells and Distinct Somatic Cell Types of the Testis1 by Nenicu, Anca, Lüers, Georg H, Kovacs, Werner, Bergmann, Martin, Baumgart-Vogt, Eveline

“…The vital importance of peroxisomal metabolism for regular function of the testis is stressed by the severe spermatogenesis defects induced by peroxisomal…”
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Peroxisomes are present in murine spermatogonia and disappear during the course of spermatogenesis by Lüers, Georg H, Thiele, Samuel, Schad, Arno, Völkl, Alfred, Yokota, Sadaki, Seitz, Jürgen

“…Peroxisomes are organelles that are almost ubiquitous in eukaryotic cells. They have, however, never been described in germ cells within the testis. Since some…”
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