Search Results - "Luebeck, E. Georg"

Impact of Tumor Progression on Cancer Incidence Curves by GEORG LUEBECK, E, CURTIUS, Kit, JEON, Jihyoun, HAZELTON, William D

“…Cancer arises through a multistage process, but it is not fully clear how this process influences the age-specific incidence curve. Studies of colorectal and…”
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Optimal Timing for Cancer Screening and Adaptive Surveillance Using Mathematical Modeling by Curtius, Kit, Dewanji, Anup, Hazelton, William D, Rubenstein, Joel H, Luebeck, Georg E

“…Cancer screening and early detection efforts have been partially successful in reducing incidence and mortality, but many improvements are needed. Although…”
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Age-specific incidence of cancer: Phases, transitions, and biological implications by Meza, Rafael, Jeon, Jihyoun, Moolgavkar, Suresh H, Luebeck, E. Georg

“…The observation that the age-specific incidence curve of many carcinomas is approximately linear on a double logarithmic plot has led to much speculation…”
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Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma by Luebeck, Georg E, Vaughan, Thomas L, Curtius, Kit, Hazelton, William D

“…Patterns of cancer incidence, viewed over extended time periods, reveal important aspects of multistage carcinogenesis. Here we show how a multistage clonal…”
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Cost-Effectiveness of Screening Patients with Gastroesophageal Reflux Disease for Barrett’s Esophagus With a Minimally Invasive Cell Sampling Device by Heberle, Curtis R., BS, Omidvari, Amir-Houshang, MD MPH, Ali, Ayman, BS, Kroep, Sonja, PhD, Kong, Chung Yin, PhD, Inadomi, John M., MD, Rubenstein, Joel H., MD MS, Tramontano, Angela C., MPH, Dowling, Emily C., MHS, Hazelton, William D., PhD, Luebeck, E. Georg, PhD, Lansdorp-Vogelaar, Iris, PhD, Hur, Chin, MD MPH

“…Abstract Background & Aims It is important to identify patients with Barrett’s esophagus (BE), the precursor to esophageal adenocarcinoma (EAC). Patients with…”
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Time-series analyses of air pollution and mortality in the United States: a subsampling approach by Moolgavkar, Suresh H, McClellan, Roger O, Dewanji, Anup, Turim, Jay, Luebeck, E Georg, Edwards, Melanie

“…Hierarchical Bayesian methods have been used in previous papers to estimate national mean effects of air pollutants on daily deaths in time-series analyses. We…”
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A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus by Curtius, Kit, Wong, Chao-Jen, Hazelton, William D, Kaz, Andrew M, Chak, Amitabh, Willis, Joseph E, Grady, William M, Luebeck, E Georg

“…Biomarkers that drift differentially with age between normal and premalignant tissues, such as Barrett's esophagus (BE), have the potential to improve the…”
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A Multiscale Model Evaluates Screening for Neoplasia in Barrett's Esophagus by Curtius, Kit, Hazelton, William D, Jeon, Jihyoun, Luebeck, E Georg

“…Barrett's esophagus (BE) patients are routinely screened for high grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) through endoscopic screening,…”
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Multistage Carcinogenesis and the Incidence of Colorectal Cancer by Luebeck, E. Georg, Moolgavkar, Suresh H.

“…We use general multistage models to fit the age-specific incidence of colorectal cancers in the Surveillance, Epidemiology, and End Results registry, which…”
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Epigenetic Aging: More Than Just a Clock When It Comes to Cancer by Yu, Ming, Hazelton, William D, Luebeck, Georg E, Grady, William M

“…The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced chronologic age is one of the most significant risk factors for…”
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Dynamics, stability and inheritance of somatic DNA methylation imprints by Sontag, Laura B., Lorincz, Matthew C., Georg Luebeck, E.

“…Recent research highlights the role of CpG methylation in genomic imprinting, histone and chromatin modification, transcriptional regulation, and ‘gene…”
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Does Folic Acid Supplementation Prevent or Promote Colorectal Cancer? Results from Model-Based Predictions by GEORG LUEBECK, E, MOOLGAVKAR, Suresh H, LIU, Amy Y, BOYNTON, Alanna, ULRICH, Cornelia M

“…Folate is essential for nucleotide synthesis, DNA replication, and methyl group supply. Low-folate status has been associated with increased risks of several…”
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Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma by Luebeck, E Georg, Curtius, Kit, Hazelton, William D, Maden, Sean, Yu, Ming, Thota, Prashanthi N, Patil, Deepa T, Chak, Amitabh, Willis, Joseph E, Grady, William M

“…Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that is called epigenetic drift…”
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Number and size distribution of colorectal adenomas under the multistage clonal expansion model of cancer by Dewanji, Anup, Jeon, Jihyoun, Meza, Rafael, Luebeck, E Georg

“…Colorectal cancer (CRC) is believed to arise from mutant stem cells in colonic crypts that undergo a well-characterized progression involving benign adenoma,…”
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Preneoplastic lesion growth driven by the death of adjacent normal stem cells by Chao, Dennis L, Eck, J. Thomas, Brash, Douglas E, Maley, Carlo C, Luebeck, E. Georg

“…Clonal expansion of premalignant lesions is an important step in the progression to cancer. This process is commonly considered to be a consequence of…”
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Multistage carcinogenesis: Impact of age, genetic, and environmental factors on the incidence of malignant mesothelioma by Moolgavkar, Suresh, Chang, Ellen T., Luebeck, E. Georg

“…The current paradigm of carcinogenesis as a cellular evolutionary process driven by mutations of a few critical driver genes has immediate logical implications…”
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Evaluation of screening strategies for pre-malignant lesions using a biomathematical approach by Jeon, Jihyoun, Meza, Rafael, Moolgavkar, Suresh H., Luebeck, E. Georg

“…We derive mathematical expressions for the size distribution of screen-detectable pre-malignant lesions, both conditional and unconditional on no prior…”
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Colorectal Cancer Incidence Trends in the United States and United Kingdom: Evidence of Right- to Left-Sided Biological Gradients with Implications for Screening by MEZA, Rafael, JEON, Jihyoun, RENEHAN, Andrew G, LUEBECK, E. Georg

“…Several lines of evidence support the premise that screening colonoscopy reduces colorectal cancer (CRC) incidence, but there may be differential benefits for…”
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The Optimal Age to Stop Endoscopic Surveillance of Patients With Barrett’s Esophagus Based on Sex and Comorbidity: A Comparative Cost-Effectiveness Analysis by Omidvari, Amir-Houshang, Hazelton, William D., Lauren, Brianna N., Naber, Steffie K., Lee, Minyi, Ali, Ayman, Seguin, Claudia, Kong, Chun Yin, Richmond, Ellen, Rubenstein, Joel H., Luebeck, Georg E., Inadomi, John M., Hur, Chin, Lansdorp-Vogelaar, Iris

“…Current guidelines recommend surveillance for patients with nondysplastic Barrett’s esophagus (NDBE) but do not include a recommended age for discontinuing…”
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Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success by Yankeelov, Thomas E., An, Gary, Saut, Oliver, Luebeck, E. Georg, Popel, Aleksander S., Ribba, Benjamin, Vicini, Paolo, Zhou, Xiaobo, Weis, Jared A., Ye, Kaiming, Genin, Guy M.

“…Hierarchical processes spanning several orders of magnitude of both space and time underlie nearly all cancers. Multi-scale statistical, mathematical, and…”
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