Search Results - "Luebbers, Alex"

Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer by Zhao, Jingyi, DiGiacomo, Vincent, Ferreras-Gutierrez, Mariola, Dastjerdi, Shiva, Ibáñez de Opakua, Alain, Park, Jong-Chan, Luebbers, Alex, Chen, Qingyan, Beeler, Aaron, Blanco, Francisco J, Garcia-Marcos, Mikel

“…Activation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell signaling widely targeted by…”
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Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein by Garcia-Marcos, Mikel, Parag-Sharma, Kshitij, Marivin, Arthur, Maziarz, Marcin, Luebbers, Alex, Nguyen, Lien T

“…Heterotrimeric G-proteins are signal transducers involved in mediating the action of many natural extracellular stimuli and many therapeutic agents…”
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Abstract 1697: Identification of Peptide Sequence Served as Genetically-Encoded or Chemical Probes to Inhibit Gαs in Cells by Zhao, JINGYI, Luebbers, Alex, Maziarz, Marcin, Garcia-Marcos, Mikel

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Abstract 2092: Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by a Gαi-binding protein by Luebbers, Alex, Zhou, Myles, Eyles, Stephen, Garcia-Marcos, Mikel

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Identification of Peptide Inhibitors of Gαs that Block its Effector Binding Site by Luebbers, Alex, Maziarz, Marcin, Garcia‐Marcos, Mikel

“…Heterotrimeric G proteins (Gαβγ) are molecular switches that alternate between “on” (GTP‐bound) and “off” (GDP‐bound) states to control the flow of signals…”
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Dissecting the Molecular Basis of Neurotransmitter Signaling Modulation by GINIP by Luebbers, Alex

“…G protein-coupled receptors (GPCRs) activate heterotrimeric G proteins (Gαβγ), which together form one of the most important signaling axes found in the cell…”
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Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP by Luebbers, Alex, Gonzalez-Hernandez, Alberto J, Zhou, Myles, Eyles, Stephen J, Levitz, Joshua, Garcia-Marcos, Mikel

“…It is well established that G-protein-coupled receptors (GPCRs) stimulated by neurotransmitters are critical for neuromodulation. Much less is known about how…”
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Probing the mutational landscape of regulators of G protein signaling proteins in cancer by DiGiacomo, Vincent, Maziarz, Marcin, Luebbers, Alex, Norris, Jillian M, Laksono, Pandu, Garcia-Marcos, Mikel

“…The advent of deep-sequencing techniques has revealed that mutations in G protein-coupled receptor (GPCR) signaling pathways in cancer are more prominent than…”
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Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits by Park, Jong-Chan, Luebbers, Alex, Dao, Maria, Semeano, Ana, Nguyen, Anh Minh, Papakonstantinou, Maria P., Broselid, Stefan, Yano, Hideaki, Martemyanov, Kirill A., Garcia-Marcos, Mikel

“…G-protein-coupled receptors (GPCRs) mediate neuromodulation through the activation of heterotrimeric G proteins (Gαβγ). Classical models depict that G protein…”
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Atypical activation of the G protein Gαq by the oncogenic mutation Q209P by Maziarz, Marcin, Leyme, Anthony, Marivin, Arthur, Luebbers, Alex, Patel, Prachi P., Chen, Zhe, Sprang, Stephen R., Garcia-Marcos, Mikel

“…The causative role of G protein–coupled receptor (GPCR) pathway mutations in uveal melanoma (UM) has been well-established. Nearly all UMs bear an activating…”
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A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins by Maziarz, Marcin, Broselid, Stefan, DiGiacomo, Vincent, Park, Jong-Chan, Luebbers, Alex, Garcia-Navarrete, Lucia, Blanco-Canosa, Juan B., Baillie, George S., Garcia-Marcos, Mikel

“…Recent evidence has revealed that heterotrimeric G-proteins can be activated by cytoplasmic proteins that share an evolutionarily conserved sequence called the…”
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A novel broad specificity fucosidase capable of core α1-6 fucose release from N-glycans labeled with urea-linked fluorescent dyes by Vainauskas, Saulius, Kirk, Charlotte H., Petralia, Laudine, Guthrie, Ellen P., McLeod, Elizabeth, Bielik, Alicia, Luebbers, Alex, Foster, Jeremy M., Hokke, Cornelis H., Rudd, Pauline M., Shi, Xiaofeng, Taron, Christopher H.

“…Exoglycosidases are often used for detailed characterization of glycan structures. Bovine kidney α-fucosidase is commonly used to determine the presence of…”
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