Search Results - "Ludwig, Michael Z."

Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded by Su, Ting, Ludwig, Michael Z., Xu, Jiajie, Fehon, Richard G.

“…The Hippo pathway is emerging as a key evolutionarily conserved signaling mechanism that controls organ size. Three membrane-associated proteins, Kibra,…”
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A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition by Wu, Chudong, Boisclair Lachance, Jean-François, Ludwig, Michael Z, Rebay, Ilaria

“…Spatiotemporally precise and robust cell fate transitions, which depend on specific signaling cues, are fundamental to the development of appropriately…”
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Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness by Ludwig, Michael Z, Manu, Kittler, Ralf, White, Kevin P, Kreitman, Martin

“…The regulatory logic of time- and tissue-specific gene expression has mostly been dissected in the context of the smallest DNA fragments that, when isolated,…”
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Rearrangements of 2.5 kilobases of noncoding DNA from the Drosophila even-skipped locus define predictive rules of genomic cis-regulatory logic by Kim, Ah-Ram, Martinez, Carlos, Ionides, John, Ramos, Alexandre F, Ludwig, Michael Z, Ogawa, Nobuo, Sharp, David H, Reinitz, John

“…Rearrangements of about 2.5 kilobases of regulatory DNA located 5' of the transcription start site of the Drosophila even-skipped locus generate large-scale…”
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Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin by He, Bin Z, Ludwig, Michael Z, Dickerson, Desiree A, Barse, Levi, Arun, Bharath, Vilhjálmsson, Bjarni J, Jiang, Pengyao, Park, Soo-Young, Tamarina, Natalia A, Selleck, Scott B, Wittkopp, Patricia J, Bell, Graeme I, Kreitman, Martin

“…The identification and validation of gene-gene interactions is a major challenge in human studies. Here, we explore an approach for studying epistasis in…”
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Functional evolution of a cis-regulatory module by Ludwig, Michael Z, Palsson, Arnar, Alekseeva, Elena, Bergman, Casey M, Nathan, Janaki, Kreitman, Martin

“…Lack of knowledge about how regulatory regions evolve in relation to their structure-function may limit the utility of comparative sequence analysis in…”
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Canalization of segmentation and its evolution in Drosophila by Lott, Susan E, Kreitman, Martin, Palsson, Arnar, Alekseeva, Elena, Ludwig, Michael Z

“…Segmentation in Drosophila embryogenesis occurs through a hierarchical cascade of regulatory gene expression driven by the establishment of a…”
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Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer by Palsson, Arnar, Wesolowska, Natalia, Reynisdóttir, Sigrún, Ludwig, Michael Z, Kreitman, Martin

“…Changes in regulatory DNA contribute to phenotypic differences within and between taxa. Comparative studies show that many transcription factor binding sites…”
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Evidence for stabilizing selection in a eukaryotic enhancer element by Ludwig, Michael Z, Bergman, Casey, Patel, Nipam H, Kreitman, Martin

“…Eukaryotic gene expression is mediated by compact cis-regulatory modules, or enhancers, which are bound by specific sets of transcription factors. The…”
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Natural variation of the expression pattern of the segmentation gene even-skipped in melanogaster by Jiang, Pengyao, Ludwig, Michael Z., Kreitman, Martin, Reinitz, John

“…The evolution of canalized traits is a central question in evolutionary biology. Natural variation in highly conserved traits can provide clues about their…”
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Sex-specific pattern formation during early Drosophila development by Manu, Ludwig, Michael Z, Kreitman, Martin

“…The deleterious effects of different X-chromosome dosage in males and females are buffered by a process called dosage compensation, which in Drosophila is…”
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Functional evolution of noncoding DNA by Ludwig, Michael Z.

“…Noncoding DNA in eukaryotes encodes functionally important signals for the regulation of chromosome assembly, DNA replication, and gene expression. The…”
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Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin by Park, Soo-Young, Ludwig, Michael Z, Tamarina, Natalia A, He, Bin Z, Carl, Sarah H, Dickerson, Desiree A, Barse, Levi, Arun, Bharath, Williams, Calvin L, Miles, Cecelia M, Philipson, Louis H, Steiner, Donald F, Bell, Graeme I, Kreitman, Martin

“…Drosophila melanogaster has been widely used as a model of human Mendelian disease, but its value in modeling complex disease has received little attention…”
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EVOLUTION AND INHERITANCE OF EARLY EMBRYONIC PATTERNING IN DROSOPHILA SIMULANS AND D. SECHELLIA by Lott, Susan E., Ludwig, Michael Z., Kreitman, Martin

“…Pattern formation in Drosophila is a widely studied example of a robust developmental system. Such robust systems pose a challenge to adaptive evolution, as…”
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ARTIFICIAL SELECTION ON EGG SIZE PERTURBS EARLY PATTERN FORMATION IN DROSOPHILA MELANOGASTER by Miles, Cecelia M., Lott, Susan E., Luengo Hendriks, Cris L., Ludwig, Michael Z., Manu,  , Williams, Calvin L., Kreitman, Martin

“…Pattern formation in Drosophila embryogenesis has been widely investigated as a developmental and evolutionary model of robustness. To ask whether genetic…”
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Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change by Ludwig, M Z, Patel, N H, Kreitman, M

“…Experimental investigations of eukaryotic enhancers suggest that multiple binding sites and trans-acting regulatory factors are often required for wild-type…”
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Divergent and conserved features in the spatial expression of the Drosophila pseudoobscura esterase-5B gene and the esterase-6 gene of Drosophila melanogaster by Tamarina, N.A. (Northwestern University Medical School, Chicago, IL.), Ludwig, M.Z, Richmond, R.C

“…The regulatory regions of homologous genes encoding esterase 6 (Est-6) of Drosophila melanogaster and esterase 5B (Est-5B) of Drosophila pseudoobscura show…”
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Nanos Plays a Conserved Role in Axial Patterning outside of the Diptera by Lall, Sabbi, Ludwig, Michael Z., Patel, Nipam H.

“…Axial patterning is a fundamental event in early development, and molecules involved in determining the body axes provide a coordinate system for subsequent…”
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Consequences of Eukaryotic Enhancer Architecture for Gene Expression Dynamics, Development, and Fitness: e1002364 by Ludwig, Michael Z, Kittler, Ralf, White, Kevin P, Kreitman, Martin

“…The regulatory logic of time- and tissue-specific gene expression has mostly been dissected in the context of the smallest DNA fragments that, when isolated,…”
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Localization of sequences controlling the spatial, temporal, and sex-specific expression of the esterase 6 locus in Drosophila melanogaster adults by Ludwig, M.Z, Tamarina, N.A, Richmond, R.C

“…The esterase 6 gene (Est-6) of Drosophila melanogaster is expressed in a variety of tissues that differ between larval and adult stages and among related…”
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