Search Results - "Ludlam, C"

Guidelines for the management of hemophilia by Srivastava, A., Brewer, A. K., Mauser-Bunschoten, E. P., Key, N. S., Kitchen, S., Llinas, A., Ludlam, C. A., Mahlangu, J. N., Mulder, K., Poon, M. C., Street, A.

“…Summary Hemophilia is a rare disorder that is complex to diagnose and to manage. These evidence‐based guidelines offer practical recommendations on the…”
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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity by Maurer, Till, Garrenton, Lindsay S, Oh, Angela, Pitts, Keith, Anderson, Daniel J, Skelton, Nicholas J, Fauber, Benjamin P, Pan, Borlan, Malek, Shiva, Stokoe, David, Ludlam, Mary J. C, Bowman, Krista K, Wu, Jiansheng, Giannetti, Anthony M, Starovasnik, Melissa A, Mellman, Ira, Jackson, Peter K, Rudolph, Joachim, Wang, Weiru, Fang, Guowei

“…The Ras gene is frequently mutated in cancer, and mutant Ras drives tumorigenesis. Although Ras is a central oncogene, small molecules that bind to Ras in a…”
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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth by Hatzivassiliou, Georgia, Song, Kyung, Yen, Ivana, Brandhuber, Barbara J., Anderson, Daniel J., Alvarado, Ryan, Ludlam, Mary J. C., Stokoe, David, Gloor, Susan L., Vigers, Guy, Morales, Tony, Aliagas, Ignacio, Liu, Bonnie, Sideris, Steve, Hoeflich, Klaus P., Jaiswal, Bijay S., Seshagiri, Somasekar, Koeppen, Hartmut, Belvin, Marcia, Friedman, Lori S., Malek, Shiva

“…Mixed signals from RAF Abnormal activation of the RAS-RAF-MEK-ERK signalling pathway is a feature of many human cancers, making it an attractive target for…”
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Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes by Kowanetz, Marcin, Wu, Xiumin, Lee, John, Tan, Martha, Hagenbeek, Thijs, Qu, Xueping, Yu, Lanlan, Ross, Jed, Korsisaari, Nina, Cao, Tim, Bou-Reslan, Hani, Kallop, Dara, Weimer, Robby, Ludlam, Mary J. C., Kaminker, Joshua S., Modrusan, Zora, van Bruggen, Nicholas, Peale, Franklin V., Carano, Richard, Meng, Y. Gloria, Ferrara, Napoleone

“…Priming of the organ-specific premetastatic sites is thought to be an important yet incompletely understood step during metastasis. In this study, we show that…”
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Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers by Hatzivassiliou, Georgia, Haling, Jacob R., Chen, Huifen, Song, Kyung, Price, Steve, Heald, Robert, Hewitt, Joanne F. M., Zak, Mark, Peck, Ariana, Orr, Christine, Merchant, Mark, Hoeflich, Klaus P., Chan, Jocelyn, Luoh, Shiuh-Ming, Anderson, Daniel J., Ludlam, Mary J. C., Wiesmann, Christian, Ultsch, Mark, Friedman, Lori S., Malek, Shiva, Belvin, Marcia

“…The mechanism of action of three different allosteric MEK inhibitors that target the MAP kinase pathway is investigated, and their efficacy is shown to be…”
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Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 by Wertz, Ingrid E., Kusam, Saritha, Lam, Cynthia, Okamoto, Toru, Sandoval, Wendy, Anderson, Daniel J., Helgason, Elizabeth, Ernst, James A., Eby, Mike, Liu, Jinfeng, Belmont, Lisa D., Kaminker, Joshua S., O’Rourke, Karen M., Pujara, Kanan, Kohli, Pawan Bir, Johnson, Adam R., Chiu, Mark L., Lill, Jennie R., Jackson, Peter K., Fairbrother, Wayne J., Seshagiri, Somasekar, Ludlam, Mary J. C., Leong, Kevin G., Dueber, Erin C., Maecker, Heather, Huang, David C. S., Dixit, Vishva M.

“…Microtubules have pivotal roles in fundamental cellular processes and are targets of antitubulin chemotherapeutics 1 . Microtubule-targeted agents such as…”
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Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis by Li, Y, Ye, X, Tan, C, Hongo, J -A, Zha, J, Liu, J, Kallop, D, Ludlam, M J C, Pei, L

“…Dysregulation of Axl and its ligand growth arrest-specific 6 is implicated in the pathogenesis of several human cancers. In this study, we have used RNAi and…”
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European retrospective study of real‐life haemophilia treatment by Berntorp, E., Dolan, G., Hay, C., Linari, S., Santagostino, E., Tosetto, A., Castaman, G., Álvarez‐Román, MT, Parra Lopez, R., Oldenburg, J., Albert, T., Scholz, U., Holmström, M., Schved, J.‐F., Trossaërt, M., Hermans, C., Boban, A., Ludlam, C., Lethagen, S.

“…Introduction Haemophilia treatment varies significantly between individuals, countries and regions and details of bleed rates, factor consumption and injection…”
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Detection of a novel DNA virus (TT virus) in blood donors and blood products by Simmonds, P, Davidson, F, Lycett, C, Prescott, LE, MacDonald, DM, Ellender, J, Yap, PL, Haydon, GH, Gillon, J, Jarvis, LM, Ludlam, CA

“…A newly discovered DNA virus, transfusion- transmitted virus (TTV), has been implicated as a cause of post-transfusion hepatitis. We investigated the frequency…”
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The treatment of bleeding in acquired haemophilia with recombinant factor VIIa: a multicentre study by Hay, C R, Negrier, C, Ludlam, C A

“…Recombinant factor VIIa was used to treat 38 patients with acquired haemophilia participating in the Novoseven compassionate-use program. 19 were male, median…”
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Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax) by Leverson, J D, Zhang, H, Chen, J, Tahir, S K, Phillips, D C, Xue, J, Nimmer, P, Jin, S, Smith, M, Xiao, Y, Kovar, P, Tanaka, A, Bruncko, M, Sheppard, G S, Wang, L, Gierke, S, Kategaya, L, Anderson, D J, Wong, C, Eastham-Anderson, J, Ludlam, M J C, Sampath, D, Fairbrother, W J, Wertz, I, Rosenberg, S H, Tse, C, Elmore, S W, Souers, A J

“…The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as…”
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Cell segmentation in images without structural fluorescent labels by Zyss, Daniel, Ribeiro, Susana A, Ludlam, Mary J C, Walter, Thomas, Fehri, Amin

“…High-content screening (HCS) provides an excellent tool to understand the mechanism of action of drugs on disease-relevant model systems. Careful selection of…”
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EUHASS: The European Haemophilia Safety Surveillance system by Makris, M, Calizzani, G, Fischer, K, Gilman, E.A, Hay, C.R.M, Lassila, R, Lambert, T, Ludlam, C.A, Mannucci, P.M

“…Abstract Pharmacovigilance is an essential element of any drug treatment and considering the history of adverse events due to products used to treat inherited…”
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The procoagulant potential of environmental particles (PM10) by Gilmour, P S, Morrison, E R, Vickers, M A, Ford, I, Ludlam, C A, Greaves, M, Donaldson, K, MacNee, W

“…Background and Aims: Epidemiology studies have shown that cardiovascular (CV) disease is primarily responsible for the mortality associated with increased…”
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Accuracy in ECG lead placement among technicians, nurses, general physicians and cardiologists by Rajaganeshan, R, Ludlam, C L, Francis, D P, Parasramka, S V, Sutton, R

“…The objective of the study was to determine the reliability of ECG precordial electrode placement by doctors and nurses involved in the emergency care of…”
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Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking : A mechanism for arterial thrombosis and myocardial infarction by NEWBY, D. E, WRIGHT, R. A, LABINJOH, C, LUDLAM, C. A, FOX, K. A. A, BOON, N. A, WEBB, D. J

“…Effective endogenous fibrinolysis requires rapid release of tissue plasminogen activator (tPA) from the vascular endothelium. Smoking is a known risk factor…”
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Consensus protocol for the use of recombinant activated factor VII [eptacog alfa (activated); NovoSeven®] in elective orthopaedic surgery in haemophilic patients with inhibitors by GIANGRANDE, P. L. F., WILDE, J. T., MADAN, B., LUDLAM, C. A., TUDDENHAM, E. G. D., GODDARD, N. J., DOLAN, G., INGERSLEV, J.

“…Patients with haemophilia complicated by inhibitors have a significant burden of joint disease, which is associated with a negative impact on their quality of…”
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Dissociation of phenotypic and functional endothelial progenitor cells in patients undergoing percutaneous coronary intervention by Mills, N L, Tura, O, Padfield, G J, Millar, C, Lang, N N, Stirling, D, Ludlam, C, Turner, M L, Barclay, G R, Newby, D E

“…Endothelial progenitor cells (EPCs) are circulating mononuclear cells with the capacity to mature into endothelial cells and contribute to vascular repair. We…”
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Infection with hepatitis G virus among recipients of plasma products by Jarvis, L M, Davidson, F, Hanley, J P, Yap, P L, Ludlam, C A, Simmonds, P

“…Hepatitis G virus (HGV or GBV-C) is a newly discovered human flavivirus distantly related to hepatitis C virus (HCV). Little information is available on its…”
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Hepatitis C infection and outcomes in the Scottish haemophilia population by Khan, M. M., Tait, R. C., Kerr, R., Ludlam, C. A., Lowe, G. D. O., Murray, W., Watson, H. G.

“…Summary Patients with bleeding disorders previously frequently became infected with hepatitis C virus. We identified the number of patients infected in…”
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