Search Results - "Ludgate, M."

Optimizing Cancer Treatments to Induce an Acute Immune Response: Radiation Abscopal Effects, PAMPs, and DAMPs by LUDGATE, Charles M

“…Clinical results indicate improved survival in poorly differentiated prostate cancer patients following a treatment schedule that maximizes hormone therapy…”
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Update in graves’ orbitopathy by Ludgate, M.

“…Summary Thyroid eye disease or Graves’ orbitopathy (GO) is an autoimmune condition most common in people with hyperthyroid Graves’ disease (GD). GD is caused…”
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The thyroid, the eyes and the gut: a possible connection by Covelli, D., Ludgate, M.

“…Introduction Graves’ disease (GD) is an autoimmune disorder responsible for 60–90% of thyrotoxicosis, with an incidence of 1 to 2 cases per 1000 population per…”
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Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ by Ruffino, J. S., Davies, N. A., Morris, K., Ludgate, M., Zhang, L., Webb, R., Thomas, A. W.

“…Purpose Monocytes may be primed towards differentiation into classically activated M1 macrophages or alternatively activated M2 macrophages. M1 macrophages…”
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Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer? by Muller, I., Giani, C., Zhang, L., Grennan‐Jones, F.A., Fiore, E., Belardi, V., Rosellini, V., Funel, N., Campani, D., Giustarini, E., Lewis, M.D., Bakhsh, A.D., Roncella, M., Ghilli, M., Vitti, P., Dayan, C.M., Ludgate, M.E.

“…Women with breast cancer (BC) and antithyroid peroxidase (TPO) autoantibodies (TPOAb) have a better prognosis than women lacking TPOAb. Sera from women with…”
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Possible Targets for Nonimmunosuppressive Therapy of Graves' Orbitopathy by Zhang, L, Grennan-Jones, F, Draman, M. S, Lane, C, Morris, D, Dayan, C. M, Tee, A. R, Ludgate, M

“…Context: Graves' orbitopathy (GO) is caused by expansion of the orbital contents by excess adipogenesis and overproduction of hyaluronan (HA)…”
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Reversal of Pathological Features of Graves' Orbitopathy by Activation of Forkhead Transcription Factors, FOXOs by Zhang, L, Ji, Q. H, Ruge, F, Lane, C, Morris, D, Tee, A. R, Dayan, C. M, Ludgate, M

“…Context: Graves' orbitopathy (GO) is a disfiguring/distressing, inflammatory autoimmune condition. This intractable problem is caused by expansion of the…”
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Animal-type melanoma: a clinical and histopathological study of 22 cases from a single institution by Ludgate, M.W., Fullen, D.R., Lee, J., Rees, R., Sabel, M.S., Wong, S.L., Johnson, T.M.

“…Summary Background  Animal‐type melanoma is a rare distinct melanoma subtype, characterized by proliferation of heavily pigmented epithelioid and spindled…”
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Current insights into the pathogenesis of Graves' orbitopathy by Eckstein, A K, Johnson, K T M, Thanos, M, Esser, J, Ludgate, M

“…Graves' orbitopathy (GO) is part of an autoimmune disease constellation comprising hyperthyroidism, orbitopathy, pretibial myxedema, and acropachy. Signs and…”
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The sodium iodide symporter is unlikely to be a thyroid/breast shared antigen by Muller, I., Zhang, L., Giani, C., Dayan, C. M., Ludgate, M. E., Grennan-Jones, F.

“…Purpose Anti-thyroid peroxidase (TPO) autoantibodies (TPOAb) seem to be protective for patients with breast cancer (BC). Thyroid and breast tissues both…”
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Unlocking the immunological mechanisms of orbital inflammation in thyroid eye disease by LUDGATE, M., BAKER, G.

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Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue by Rice, S.P.L., Zhang, L., Grennan-Jones, F., Agarwal, N., Lewis, M.D., Rees, D.A., Ludgate, M.

“…Dehydroepiandrosterone (DHEA), a precursor sex steroid, circulates in sulphated form (DHEAS). Serum DHEAS concentrations are inversely correlated with…”
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Tobramycin-induced aquagenic wrinkling of the palms in a patient with cystic fibrosis by Ludgate, M. W., Patel, D., Lamb, S.

“…Summary Aquagenic wrinkling of the palms (AWP) is a rare condition, defined clinically by the appearance or accentuation of an asymmetrical, translucent to…”
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Extreme-Risk Prostate Adenocarcinoma Presenting With Prostate-Specific Antigen (PSA) >40 ng/ml: Prognostic Significance of the Preradiation PSA Nadir by Alexander, Abraham S., M.D., F.R.C.P.C, Mydin, Aminudin, M.D, Jones, Stuart O., B.Sc, Christie, Jennifer, B.Sc, Lim, Jan T.W., M.D., F.R.C.P.C, Truong, Pauline T., M.D., F.R.C.P.C, Ludgate, Charles M., M.D., F.R.C.P.C

“…Purpose To examine the impact of patient, disease, and treatment characteristics on survival outcomes in patients treated with neoadjuvant androgen deprivation…”
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Genetic Immunization Against the Human Thyrotropin Receptor Causes Thyroiditis and Allows Production of Monoclonal Antibodies Recognizing the Native Receptor by Costagliola, S, Rodien, P, Many, M.-C, Ludgate, M, Vassart, G

“…The generation of Abs recognizing the native structure of the human thyrotropin receptor (hTSHR) has been difficult because there is currently no method…”
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Development of an Animal Model of Autoimmune Thyroid Eye Disease by Many, M.-C, Costagliola, S, Detrait, M, Denef, J.-F, Vassart, G, Ludgate, M

“…In previous studies we have transferred thyroiditis to naive BALB/c and NOD mice with human thyrotropin (TSH) receptor (TSHR)-primed splenocytes. Because the…”
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A new form of familial multi-nodular goitre with progression to differentiated thyroid cancer by Bakhsh, A, Kirov, G, Gregory, J W, Williams, E D, Ludgate, M

“…We report a kindred with euthyroid multi-nodular goitre (MNG) of adolescent onset. Two of the seven subjects with MNG have progressed to papillary thyroid…”
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The W546X Mutation of the Thyrotropin Receptor Gene: Potential Major Contributor to Thyroid Dysfunction in a Caucasian Population by Jordan, N., Williams, N., Gregory, J. W., Evans, C., Owen, M., Ludgate, M.

“…Congenital hypothyroidism (CH) occurs in approximately 1 in 3000 births and can be caused by mutations in 9 known genes, including that encoding the TSH…”
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Adipose thyrotrophin receptor expression is elevated in Graves' and thyroid eye diseases ex vivo and indicates adipogenesis in progress in vivo by Starkey, KJ, Janezic, A, Jones, G, Jordan, N, Baker, G, Ludgate, M

“…The thyrotrophin receptor (TSHR) provides an autoantigenic link between the thyroid and orbit in Graves' (GD) and thyroid eye diseases (TED). We measured TSHR…”
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Biological Activity of Activating Thyroid-Stimulating Hormone Receptor Mutants Depends on the Cellular Context by Fuhrer, D, Lewis, M. D, Alkhafaji, F, Starkey, K, Paschke, R, Wynford-Thomas, D, Eggo, M, Ludgate, M

“…Activating TSH receptor (TSHR) mutations are a major cause of toxic thyroid adenoma and familial hyperthyroidism, and more than 37 such mutations have been…”
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