Search Results - "Ludens, J. H."

Identification and Characterization of a Ouabain-Like Compound from Human Plasma by Hamlyn, J. M., Blaustein, M. P., Bova, S., DuCharme, D. W., Harris, D. W., Mandel, F., Mathews, W. R., Ludens, J. H.

“…The plasma membrane sodium-potassium pumps that regulate intracellular sodium in most animal cells have specific, high-affinity receptors for the digitalis…”
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U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist by Vonvoigtlander, P F, Lahti, R A, Ludens, J H

“…U-50,488 (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide) displays analgesic actions in a variety (thermal, pressure and…”
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Observations on the Nature, Biosynthesis, Secretion and Significance of Endogenous Ouabain by Hamlyn, John M., Lu, Zhuo-Ren, Manunta, Paolo, Ludens, James H., Kimura, Keizo, Shah, Jui R., Laredo, James, Hamilton, James P., Hamilton, Matthew J., Hamilton, Bruce P.

“…The human circulation contains four readily distinguishable biologically active inhibitors of the sodium pump that appear to be endogenous to mammals. Of…”
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Mass Spectral Characterization of an Endogenous Digitalislike Factor From Human Plasma by Mathews, W Rodney, DuCharme, Donald W, Hamlyn, John M, Harris, Douglas W, Mandel, Frederic, Clark, Michael A, Ludens, James H

“…A sodium pump inhibitor has been isolated from human plasma and extensively purified. This material, endogenous digitalislike factor, was examined by a variety…”
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Digitalis-like activity in human plasma. Purification, affinity, and mechanism by HAMLYN, J. M, HARRIS, D. W, LUDENS, J. H

“…A factor having digitalis-like characteristics has been isolated from human plasma and its mechanism of action compared with the commonly used cardenolide,…”
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Unique natriuretic properties of the ATP-sensitive K(+)-channel blocker glyburide in conscious rats by Clark, M A, Humphrey, S J, Smith, M P, Ludens, J H

“…Small-conductance, ATP-sensitive K(+)-channels (KATP) localized in apical membranes of both thick ascending limb of the loop of Henle and cortical collecting…”
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Purification of an Endogenous Digitalislike Factor From Human Plasma for Structural Analysis by Ludens, James H, Clark, Michael A, DuChanne, Donald W, Harris, Douglas W, Lutzke, Barry S, Mandel, Frederic, Mathews, W Rodney, Sutter, Dorothy M, Hamlyn, John M

“…In previous reports, we described the isolation and characterization of an endogenous digitalislike factor (EDLF). In this report, we describe a unique…”
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Effects of a K+ channel blocker on glomerular filtration rate and electrolyte excretion in conscious rats by Ludens, J H, Clark, M A, Lawson, J A

“…Effects of a K+ channel blocker on glomerular filtration rate and electrolyte excretion in conscious rats were observed. Effects of K+ channel modulation on…”
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Glyburide attenuates calmodulin antagonist-stimulated renin release from isolated mouse juxtaglomerular cells by Linseman, D A, Lawson, J A, Jones, D A, Ludens, J H

“…Previous reports have shown that K+ channel openers elevate plasma renin activity in vivo and stimulate renin release (RR) from juxtaglomerular (JG) cells in…”
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Studies on the nature and mechanism of the diuretic activity of the opioid analgesic ethylketocyclazocine by Slizgi, G R, Ludens, J H

“…Subcutaneous injection (0.1 - 3.0 mg/kg) of ethylketocyclazocine (EKC; a prototype kappa agonist) resulted in a dose-dependent increase in urine formation in…”
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Development of an Immunoassay for Endogenous Digitalislike Factor by Harris, Douglas W, Clark, Michael A, Fisher, Jed F, Hamlyn, John M, Kolbasa, Karen P, Ludens, James H, DuCharme, Donald W

“…Recently, attempts to purify and identify a circulating inhibitor of the sodium pump have been successful. Based on the outcome of mass spectral analysis of…”
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Digitalis-like factor and ouabain-like compound in plasma of volume-expanded dogs by Ludens, J H, Clark, M A, Kolbasa, K P, Hamlyn, J M

“…Previous studies demonstrated that ouabain-like compound (OLC) is widely distributed in mammalian species and is found in a variety of different tissues…”
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Effects of an Endogenous Ouabainlike Compound on Heart and Aorta by Bova, Sergio, Blaustein, Mordecai P, Ludens, James H, Harris, Douglas W, DuCharme, Donald W, Hamlyn, John M

“…An endogenous ouabainlike compound (OLC) has been purified from human plasma, and mass spectrometry has shown it to be indistinguishable from plant-derived…”
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K-ATP-Blocking Diuretic PNU-37883A Reduces Plasma Renin Activity in Dogs by Humphrey, Stephen J, Ludens, James H

“…We determined the effects of the K-adenosine triphosphate (ATP)-blocking diuretic PNU-37883A on plasma renin activity (PRA) in conscious and anesthetized dogs…”
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Effects of the highly selective kappa opioid, U-50, 488, on renal function in the anesthetized dog by Slizgi, G R, Taylor, C J, Ludens, J H

“…Intravenous administration of U-50,488 (a chemically novel and highly selective kappa agonist) resulted in dose-dependent increases in urine formation in…”
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K+ channel blockers : Natriuretic potency correlates to vascular ATP-sensitive K+ channel blockade by CLARK, M. A, LAWSON, J. A, LUDENS, J. H

“…Using analogs of known vascular ATP-sensitive K+ channel (KATP) blockers, we identified compounds with a wide range of potencies (over 500-fold) in their…”
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Renal and vascular effects of chemically distinct ATP-sensitive K+ channel blockers in rats by Ludens, J H, Clark, M A, Smith, M P, Humphrey, S J

“…The ATP-sensitive K+ channel blocker U-37883A was given intravenously (i.v.) to rats to determine if pharmacologic diversity among ATP-sensitive K+ channels…”
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Protection from ischemia-induced cerebral edema in the rat by U-50488H, a kappa opioid receptor agonist by Silvia, R C, Slizgi, G R, Ludens, J H, Tang, A H

“…U-50488 is a specific kappa opioid agonist which produces in rats water diuresis resulting in an elevation of plasma osmolarity. Pretreatment with U-50488H…”
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Nature of the inhibition of Cl- transport by furosemide: evidence for competitive inhibition of active transport in toad cornea by Ludens, J H

“…Furosemide inhibits short-circuit current (active Cl- transport) in isolated toad cornea, a model of the thick ascending limb of the loop of Henle. The…”
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Effect of chronic treatment on the cardiovascular and behavioral responses of 8-OH-DPAT in conscious normotensive rats by Kolbasa, K P, McCall, R B, Ludens, J H

“…Cardiovascular and behavioral responses induced by intravenous administration of the serotonin (5-HT)1A receptor agonist,…”
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