Search Results - "Ludeke, Barbara"

Structure of the human metapneumovirus polymerase phosphoprotein complex by Pan, Junhua, Qian, Xinlei, Lattmann, Simon, El Sahili, Abbas, Yeo, Tiong Han, Jia, Huan, Cressey, Tessa, Ludeke, Barbara, Noton, Sarah, Kalocsay, Marian, Fearns, Rachel, Lescar, Julien

“…Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) cause severe respiratory diseases in infants and elderly adults 1 . No vaccine or effective…”
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Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses by Yoon, Jeong-Joong, Toots, Mart, Lee, Sujin, Lee, Myung-Eun, Ludeke, Barbara, Luczo, Jasmina M, Ganti, Ketaki, Cox, Robert M, Sticher, Zachary M, Edpuganti, Vindya, Mitchell, Deborah G, Lockwood, Mark A, Kolykhalov, Alexander A, Greninger, Alexander L, Moore, Martin L, Painter, George R, Lowen, Anice C, Tompkins, Stephen M, Fearns, Rachel, Natchus, Michael G, Plemper, Richard K

“…Morbidity and mortality resulting from influenza-like disease are a threat, especially for older adults. To improve case management, next-generation…”
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Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases by Shareef, Afzaal M, Ludeke, Barbara, Jordan, Paul, Deval, Jerome, Fearns, Rachel

“…It is generally thought that the promoters of non-segmented, negative strand RNA viruses (nsNSVs) direct the polymerase to initiate RNA synthesis exclusively…”
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Structural basis for dimerization of a paramyxovirus polymerase complex by Xie, Jin, Ouizougun-Oubari, Mohamed, Wang, Li, Zhai, Guanglei, Wu, Daitze, Lin, Zhaohu, Wang, Manfu, Ludeke, Barbara, Yan, Xiaodong, Nilsson, Tobias, Gao, Lu, Huang, Xinyi, Fearns, Rachel, Chen, Shuai

“…The transcription and replication processes of non-segmented, negative-strand RNA viruses (nsNSVs) are catalyzed by a multi-functional polymerase complex…”
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Polymerase-tagged respiratory syncytial virus reveals a dynamic rearrangement of the ribonucleocapsid complex during infection by Blanchard, Emmeline L, Braun, Molly R, Lifland, Aaron W, Ludeke, Barbara, Noton, Sarah L, Vanover, Daryll, Zurla, Chiara, Fearns, Rachel, Santangelo, Philip J

“…The ribonucleocapsid complex of respiratory syncytial virus (RSV) is responsible for both viral mRNA transcription and viral replication during infection,…”
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The respiratory syncytial virus polymerase can perform RNA synthesis with modified primers and nucleotide analogs by Ludeke, Barbara, Fearns, Rachel

“…Respiratory syncytial virus (RSV) is significant for public health, capable of causing respiratory tract disease in infants, the elderly and the…”
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Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex by Cox, Robert M., Toots, Mart, Yoon, Jeong-Joong, Sourimant, Julien, Ludeke, Barbara, Fearns, Rachel, Bourque, Elyse, Patti, Joseph, Lee, Edward, Vernachio, John, Plemper, Richard K.

“…Respiratory syncytial virus (RSV) represents a significant health threat to infants and to elderly or immunocompromised individuals. There are currently no…”
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Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen by Duvall, Jeremy R, VerPlank, Lynn, Ludeke, Barbara, McLeod, Sarah M, Lee, 4th, Maurice D, Vishwanathan, Karthick, Mulrooney, Carol A, Le Quement, Sebastian, Yu, Qin, Palmer, Michelle A, Fleming, Paul, Fearns, Rachel, Foley, Michael A, Scherer, Christina A

“…Respiratory syncytial virus (RSV) infections affect millions of children and adults every year. Despite the significant disease burden, there are currently no…”
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DNA methylation in various rat tissues by the esophageal carcinogen N-nitrosomethyl-n-amylamine and six of its positional isomers by Ji, Chuan, Ludeke, Barbara I, Kleihues, Paul, Wiessler, Manfred

“…The major pathway for the bioactivation of asymmetric N-nitrosomethylalkylamines involves cytochrome P-450 catalyzed alpha-C hydroxylation of the alkyl moiety…”
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p53 protein accumulation and gene mutations in human glioma cell lines by Anker, L, Ohgaki, H, Ludeke, B I, Herrmann, H D, Kleihues, P, Westphal, M

“…Mutations in, and aberrant expression of, the p53 tumor suppressor gene were assessed in 17 cell lines derived from human malignant brain tumors (glioblastoma…”
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p53 mutations in phenacetin-associated human urothelial carcinomas by Petersen, I, Ohgaki, H, Ludeke, B I, Kleihues, P

“…Chronic abuse of the analgesic drug phenacetin is associated with an increased risk of development of transitional cell carcinomas of the urinary tract. It is…”
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Modulation of N-nitrosomethylbenzylamine bioactivation by diallyl sulfide in vivo by Ludeke, B I, Dominé, F, Ohgaki, H, Kleihues, P

“…Diallyl sulfide (DAS), a major component of garlic oil, is an inhibitor of tumorigenesis by various metabolically activated carcinogens. In rats, pretreatment…”
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Direct DNA sequencing following SSCP analysis by Petersen, I, Ohgaki, H, Ludeke, B, Kleihues, P

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Organ and cell specificity of DNA methylation by N-nitrosomethylamylamine in rats by KOENIGSMANN, M, SCHMEROLD, I, JELTSCH, W, LUDEKE, B, KLEIHUES, P, WIESSLER, M

“…N-Nitrosomethylamylamine (NMAA) is a potent carcinogen in rodents with the esophagus as the principal target organ. The present study aims at an assessment of…”
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DNA methylation in the digestive tract of F344 rats during chronic exposure toN-methyl-N-nitrosourea by Ohgaki, Hiroko, Ludeke, Barbara I., Meier, Irene, Kleihues, Paul, Lutz, Werner K., Schlatter, Christian

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DNA methylation in rat stomach and duodenum following chronic exposure to N-methyl-N'-nitro-N-nitrosoguanidine and the effect of dietary taurocholate by Kobori, O, Schmerold, I, Ludeke, B, Ohgaki, H, Kleihues, P

“…N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) induces a high incidence of carcinomas in the glandular stomach of rats following chronic administration in the…”
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Formation and persistence of O6-(2-hydroxyethyl)-2' -deoxyguanosine in DNA of various rat tissues following a single dose of N-nitroso-N-(2-hydroxyethyl)urea. An immuno-slot-blot study by Ludeke, B I, Kleihues, P

“…Rabbit antibodies against O6-(2-hydroxyethyl)-2'-deoxyguanosine (O6-HEdg) were used to develop a highly sensitive immuno-slot-blot assay for this promutagenic…”
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Stimulation of intestinal Na+/D-glucose cotransport by monoclonal antibodies by HONOLD, K, LUDEKE, B, HENGARTNER, H, SEMENZA, G

“…The small intestinal brush border membrane is endowed with a number of transport systems. Monoclonal antibodies were produced against integral membrane…”
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DNA methylation in the digestive tract of F344 rats during chronic exposure to N-methyl-N-nitrosourea by Ohgaki, H, Ludeke, B I, Meier, I, Kleihues, P, Lutz, W K, Schlatter, C

“…The formation of O6-methyldeoxyguanosine (O6-MedGuo) was determined by an immuno-slot-blot assay in DNA of various tissues of F344 rats exposed to…”
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Interference of aromatic sulfo groups in the microbial degradation of the azo dyes orange I and orange II by Kulla, H.G, Klausener, F, Meyer, U, Ludeke, B, Leisinger, T

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