Search Results - "Ludbrook, Valerie J."

Inhibition of Receptor-Interacting Protein Kinase 1 in Chronic Plaque Psoriasis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study by Ludbrook, Valerie J., Budd, David C., Thorn, Katie, Tompson, Debra, Votta, Bartholomew J., Walker, Lucy, Lee, Amy, Chen, Xin, Peppercorn, Amanda, Loo, Wei Jing

“…Introduction Receptor-interacting protein kinase 1 (RIPK1), a key mediator of inflammation through necroptosis and proinflammatory cytokine production, may…”
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Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough by Ludbrook, Valerie J., Hanrott, Kate E., Kreindler, James L., Marks-Konczalik, Joanna E., Bird, Nick P., Hewens, Debbie A., Beerahee, Misba, Behm, David J., Morice, Alyn, McGarvey, Lorcan, Parker, Sean M., Birring, Surinder S., Smith, Jaclyn

“…Objective Airway sensory nerves involved in the cough reflex are activated by adenosine triphosphate (ATP) agonism of P2X purinoceptor 3 (P2X3) receptors…”
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A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development by Dickson, Marion C., Ludbrook, Valerie J., Perry, Hayley C., Wilson, Paul A., Garthside, Sam J., Binks, Michael H.

“…Objectives To investigate Toll-like receptor activation in human skin using tape stripping and imiquimod cream challenges in healthy volunteers. Subjects,…”
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Mo1701 Selective Janus Kinase 1 Inhibitor Targets Monocytes and Tissue Macrophages During DSS Colitis by De Vries, Leonie C, Duarte, Jose, Hilbers, Francisca, de Winther, Menno, Moerland, Perry, Woodrow, Michael D, Sims, Martin J, Ludbrook, Valerie J, D'Haens, Geert R, de Jonge, Wouter

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Mo1723 Comparative Efficacies of Novel JAK Inhibitors to Reduce Macrophage Activation by De Vries, Leonie C, Duarte, Jose, Hilbers, Francisca, Ludbrook, Valerie J, Woodrow, Michael D, Sims, Martin J, de Winther, Menno, Moerland, Perry, D'Haens, Geert R, de Jonge, Wouter

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Mo1738 Efficacy of a Novel JAK1-Specific Inhibitor in a Mouse Model of Acute and Chronic Colitis by Duarte, Jose, De Vries, Leonie C, Hilbers, Francisca, de Winther, Menno, Sims, Martin J, Ludbrook, Valerie J, Woodrow, Michael D, Witherington, Jason, D'Haens, Geert R, de Jonge, Wouter

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GSK2586184, a JAK1 selective inhibitor, in two patients with ulcerative colitis by De Vries, Leonie C.S., Ludbrook, Valerie J., Hicks, Kirsty J., D'Haens, Geert R.

“…Tofacitinib, a non-selective Janus kinase (JAK) inhibitor, is effective in inducing clinical and endoscopic remission in patients with active ulcerative…”
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Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation by McLaughlin, Fiona, Ludbrook, Valerie J., Cox, Joanne, von Carlowitz, Ira, Brown, Suzy, Randi, Anna M.

“…It has recently been shown that the transcription factor Erg, an Ets family member, drives constitutive expression of the intercellular adhesion molecule 2…”
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Characterisation of the tumour necrosis factor (TNF)-α response elements in the human ICAM-2 promoter by McLaughlin, Fiona, Ludbrook, Valerie J., Kola, Ismail, Campbell, Callum J., Randi, Anna M.

“…ABSTRACT ICAM-2 is a cell surface adhesion molecule constitutively expressed on the endothelium, involved in leukocyte recruitment into tissues. We recently…”
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