Search Results - "Ludbrook, J"

Federated Learning Survival Model and Potential Radiotherapy Decision Support Impact Assessment for Non–small Cell Lung Cancer Using Real-World Data by Field, M., Vinod, S., Delaney, G.P., Aherne, N., Bailey, M., Carolan, M., Dekker, A., Greenham, S., Hau, E., Lehmann, J., Ludbrook, J., Miller, A., Rezo, A., Selvaraj, J., Sykes, J., Thwaites, D., Holloway, L.

“…The objective of this study was to develop a two-year overall survival model for inoperable stage I-III non–small cell lung cancer (NSCLC) patients using…”
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Repeated measurements and multiple comparisons in cardiovascular research by Ludbrook, J

“…In cardiovascular research, experiments are commonly performed in which repeated measurements are made in the same individual at predetermined intervals of…”
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Inhibition of Receptor-Interacting Protein Kinase 1 in Chronic Plaque Psoriasis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study by Ludbrook, Valerie J., Budd, David C., Thorn, Katie, Tompson, Debra, Votta, Bartholomew J., Walker, Lucy, Lee, Amy, Chen, Xin, Peppercorn, Amanda, Loo, Wei Jing

“…Introduction Receptor-interacting protein kinase 1 (RIPK1), a key mediator of inflammation through necroptosis and proinflammatory cytokine production, may…”
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Definition of ambulatory blood pressure targets for diagnosis and treatment of hypertension in relation to clinic blood pressure: prospective cohort study by Head, Geoffrey A, Mihailidou, Anastasia S, Duggan, Karen A, Beilin, Lawrence J, Berry, Narelle, Brown, Mark A, Bune, Alex J, Cowley, Diane, Chalmers, John P, Howe, Peter R C, Hodgson, Jonathan, Ludbrook, John, Mangoni, Arduino A, McGrath, Barry P, Nelson, Mark R, Sharman, James E, Stowasser, Michael

“…Background Twenty-four hour ambulatory blood pressure thresholds have been defined for the diagnosis of mild hypertension but not for its treatment or for…”
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First clinical experience with real-time portal imaging-based breath-hold monitoring in tangential breast radiotherapy by Vasina, Elena N., Kong, Natalie, Greer, Peter, Baeza Ortega, Jose, Kron, Tomas, Ludbrook, Joanna J., Thwaites, David, Lehmann, Joerg

“…Real-time treatment monitoring with the electronic portal imaging device (EPID) can conceptually provide a more accurate assessment of the quality of deep…”
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Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough by Ludbrook, Valerie J., Hanrott, Kate E., Kreindler, James L., Marks-Konczalik, Joanna E., Bird, Nick P., Hewens, Debbie A., Beerahee, Misba, Behm, David J., Morice, Alyn, McGarvey, Lorcan, Parker, Sean M., Birring, Surinder S., Smith, Jaclyn

“…OBJECTIVEAirway sensory nerves involved in the cough reflex are activated by adenosine triphosphate (ATP) agonism of P2X purinoceptor 3 (P2X3) receptors…”
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Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation by McLaughlin, Fiona, Ludbrook, Valerie J., Cox, Joanne, von Carlowitz, Ira, Brown, Suzy, Randi, Anna M.

“…It has recently been shown that the transcription factor Erg, an Ets family member, drives constitutive expression of the intercellular adhesion molecule 2…”
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Statistics in physiology and pharmacology: a slow and erratic learning curve by Ludbrook, J

“…1. Learning how to apply statistical analyses to the results of experimental or clinical studies may take a lifetime of trial (and sometimes error), as it has…”
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Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals by Schadt, J C, Ludbrook, J

“…In conscious mammals including humans, the neurohumoral and hemodynamic responses to progressive acute hypovolemia have two distinct phases. There is an…”
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Investigation of selective JAK1 inhibitor GSK2586184 for the treatment of psoriasis in a randomized placebo-controlled phase IIa study by Ludbrook, V.J., Hicks, K.J., Hanrott, K.E., Patel, J.S., Binks, M.H., Wyres, M.R., Watson, J., Wilson, P., Simeoni, M., Schifano, L.A., Reich, K., Griffiths, C.E.M.

“…Summary Background GSK2586184 is a selective oral Janus kinase (JAK)1 inhibitor being evaluated as a treatment for moderate‐to‐severe plaque‐type psoriasis…”
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International comparison of cosmetic outcomes of breast conserving surgery and radiation therapy for women with ductal carcinoma in situ of the breast by Olivotto, Ivo A., Link, Emma, Phillips, Claire, Whelan, Timothy J., Bryant, Guy, Kunkler, Ian H., Westenberg, A. Helen, Purohit, Kash, Ahern, Verity, Graham, Peter H., Akra, Mohamed, McArdle, Orla, Ludbrook, Joanna J., Harvey, Jennifer A., Maduro, John H., Kirkove, Carine, Gruber, Guenther, Martin, Joseph D., Campbell, Ian D., Delaney, Geoff P., Chua, Boon H.

“…•Cosmetic outcomes of BCS for DCIS were independent of treating centre geography.•Conventional and hypofractionated WBI achieved similar 3-year…”
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The Wilcoxon-Mann-Whitney test condemned by Ludbrook, J.

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Activation of brain neurons following central hypervolaemia and hypovolaemia: contribution of baroreceptor and non-baroreceptor inputs by Potts, P.D., Ludbrook, J., Gillman-Gaspari, T.A., Horiuchi, J., Dampney, R.A.L.

“…In the present study we have used the detection of Fos, the protein product of c- fos, to determine the distribution of neurons in the medulla and hypothalamus…”
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Computer-intensive statistical procedures by Ludbrook, J

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Statistical Techniques For Comparing Measurers And Methods Of Measurement: A Critical Review by Ludbrook, John

“…SUMMARY 1. Clinical and experimental pharmacologists and physiologists often wish to compare two methods of measurement, or two measurers. 2. Biostatisticians…”
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PO-1654 Back arching during tangential DIBH breast RT detected with live EPID based position monitoring by Vasina, E., Kong, N., Ludbrook, J., Govindarajulu, G., Greer, P., Lehmann, J.

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PD-0855 First patient experience with real-time EPID-based breath hold monitoring during breast radiotherapy by Vasina, E., Greer, P., Baeza Ortega, J., Kron, T., Ludbrook, J., Thwaites, D., Lehmann, J.

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Roles of carotid baroreceptor and cardiac afferents in hemodynamic responses to acute central hypovolemia by Ludbrook, J, Ventura, S

“…When central blood volume is progressively reduced, there is a biphasic hemodynamic response. In phase I, sympathetic vasoconstrictor drive and systemic…”
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A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development by Dickson, Marion C., Ludbrook, Valerie J., Perry, Hayley C., Wilson, Paul A., Garthside, Sam J., Binks, Michael H.

“…Objectives To investigate Toll-like receptor activation in human skin using tape stripping and imiquimod cream challenges in healthy volunteers. Subjects,…”
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Mo1701 Selective Janus Kinase 1 Inhibitor Targets Monocytes and Tissue Macrophages During DSS Colitis by De Vries, Leonie C, Duarte, Jose, Hilbers, Francisca, de Winther, Menno, Moerland, Perry, Woodrow, Michael D, Sims, Martin J, Ludbrook, Valerie J, D'Haens, Geert R, de Jonge, Wouter

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