Search Results - "Luczak, Michal W"

Effects of hydroxylated resveratrol analogs on oxidative stress and cancer cells death in human acute T cell leukemia cell line: prooxidative potential of hydroxylated resveratrol analogs by Kucinska, Malgorzata, Piotrowska, Hanna, Luczak, Michał W, Mikula-Pietrasik, Justyna, Ksiazek, Krzysztof, Wozniak, Milena, Wierzchowski, Marcin, Dudka, Jaroslaw, Jäger, Walter, Murias, Marek

“…Resveratrol and its higher hydroxylated analogs have been reported to possess a variety of biological properties including antioxidant as well as prooxidant…”
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Vulnerability of HIF1α and HIF2α to damage by proteotoxic stressors by Meyers, Lauren M., Krawic, Casey, Luczak, Michal W., Zhitkovich, Anatoly

“…Transcription factors HIF1 and HIF2 are central regulators of physiological responses to hypoxia and important for normal functioning of tissue stem cells and…”
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HMGB1 Carried by Small Extracellular Vesicles Potentially Plays a Role in Promoting Acquired Middle Ear Cholesteatoma by Łuczak, Michał W, Dżaman, Karolina, Zaręba, Łukasz, Czerwaty, Katarzyna, Siewiera, Jacek, Głuszko, Alicja, Olszewska, Ewa, Brzost, Jacek, Kantor, Ireneusz, Szczepański, Mirosław J, Ludwig, Nils

“…Cholesteatoma is a specific medical condition involving the abnormal, non-cancerous growth of skin-like tissue in the middle ear, potentially leading to a…”
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20S immunoproteasomes remove formaldehyde-damaged cytoplasmic proteins suppressing caspase-independent cell death by Ortega-Atienza, Sara, Krawic, Casey, Watts, Lauren, McCarthy, Caitlin, Luczak, Michal W., Zhitkovich, Anatoly

“…Immunoproteasomes are known for their involvement in antigen presentation. However, their broad tissue presence and other evidence are indicative of nonimmune…”
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Sensitive Detection of Histones and γ‑H2AX by Immunoblotting: Problems and Solutions by Krawic, Casey, Luczak, Michal W., Zhitkovich, Anatoly

“…Histones and their posttranslational modifications (PTMs) are critical regulators of gene expression. Differentiation, environmental stressors, xenobiotics,…”
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Increased expression of HIF-1A and its implication in the hypoxia pathway in primary advanced uterine cervical carcinoma by LUCZAK, Michał W, ROSZAK, Andrzej, PAWLIK, Piotr, KEDZIA, Helena, LIANERI, Margarita, JAGODZINSKI, Pawel P

“…The development of cervical cancer exhibits some unique differences compared to other solid tumors. Normal cervical stratified epithelia have characteristics…”
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Monoubiquitinated γ-H2AX: Abundant product and specific biomarker for non-apoptotic DNA double-strand breaks by Luczak, Michal W., Zhitkovich, Anatoly

“…DNA double-strand breaks (DSBs) are a highly toxic form of DNA damage produced by a number of carcinogens, drugs, and metabolic abnormalities. Involvement of…”
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NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells by Luczak, Michal W., Krawic, Casey, Zhitkovich, Anatoly

“…The hypoxia-induced transcription factor HIF1 inhibits cell growth in normoxia through poorly understood mechanisms. A constitutive upregulation of hypoxia…”
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Role of direct reactivity with metals in chemoprotection by N-acetylcysteine against chromium(VI), cadmium(II), and cobalt(II) by Luczak, Michal W, Zhitkovich, Anatoly

“…The antioxidant N-acetylcysteine (NAC) is widely used for the assessment of the role of reactive oxygen species (ROS) in various biological processes and…”
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Atypical genotoxicity of carcinogenic nickel(II): Linkage to dNTP biosynthesis, DNA-incorporated rNMPs, and impaired repair of TOP1-DNA crosslinks by Krawic, Casey, Luczak, Michal W., Valiente, Sophia, Zhitkovich, Anatoly

“…Cancer is a genetic disease requiring multiple mutations for its development. However, many carcinogens are DNA-unreactive and nonmutagenic and consequently…”
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p53 Activation by Cr(VI): A Transcriptionally Limited Response Induced by ATR Kinase in S-Phase by Luczak, Michal W, Krawic, Casey, Zhitkovich, Anatoly

“…Cellular reduction of carcinogenic chromium(VI) causes several forms of Cr-DNA damage with different genotoxic properties. Chromate-treated cultured cells have…”
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Monoubiquitinated H2B, a Main Chromatin Target of Formaldehyde, Is Important for S‐Phase Checkpoint Signaling and Genome Stability by Mishra, Sasmita, Krawic, Casey, Luczak, Michal W., Zhitkovich, Anatoly

“…ABSTRACT Formaldehyde (FA) is a human carcinogen with ubiquitous environmental exposures and significant endogenous formation. Genotoxic activity of FA stems…”
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Transcriptional analysis of CXCR4, DNMT3A, DNMT3B and DNMT1 gene expression in primary advanced uterine cervical carcinoma by LUCZAK, Michał W, ROSZAK, Andrzej, PAWLIK, Piotr, KEDZIA, Helena, KEDZIA, Witold, MALKOWSKA- WALCZAK, Blanka, LIANERI, Margarita, JAGODZINSKI, Paweł P

“…The development of cervical cancer requires genetic and epigenetic factors which result in the persistence of a malignant phenotype. Cervical cancer exhibits…”
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Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin by Rubis, Blazej, Luczak, Michal W., Krawic, Casey, Zhitkovich, Anatoly

“…Bleomycin is a redox-active drug with anticancer and other clinical applications. It is also frequently used as a tool in fundamental research on cellular…”
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Nickel-induced HIF-1α promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cells by Luczak, Michal W., Zhitkovich, Anatoly

“…Nickel is a human carcinogen that acts as a hypoxia mimic by activating the transcription factor HIF-1α and hypoxia-like transcriptomic responses. Hypoxia and…”
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Monitoring Cr Intermediates and Reactive Oxygen Species with Fluorescent Probes during Chromate Reduction by DeLoughery, Zachary, Luczak, Michal W, Zhitkovich, Anatoly

“…Cr­(VI) genotoxicity is caused by products of its reductive metabolism inside the cells. Reactive oxygen species (ROS) and Cr­(V,IV) intermediates are…”
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Variation in Extracellular Detoxification Is a Link to Different Carcinogenicity among Chromates in Rodent and Human Lungs by Krawic, Casey, Luczak, Michal W, Zhitkovich, Anatoly

“…Inhalation of soluble chromium­(VI) is firmly linked with higher risks of lung cancer in humans. However, comparative studies in rats have found a high lung…”
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DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination by DeLoughery, Zachary, Luczak, Michal W, Ortega-Atienza, Sara, Zhitkovich, Anatoly

“…Hexavalent chromium is a human respiratory carcinogen that undergoes intracellular activation in vivo primarily via reduction with ascorbate. Replication of…”
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Cytotoxic activity of 3,3′,4,4′,5,5′-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase by Murias, Marek, Luczak, Michal W., Niepsuj, Anna, Krajka-Kuzniak, Violetta, Zielinska-Przyjemska, Malgorzata, Jagodzinski, Pawel P., Jäger, Walter, Szekeres, Thomas, Jodynis-Liebert, Jadwiga

“…The phytochemical resveratrol, which is found in grapes and red wine, has been reported to have a variety of biological properties. It was shown in our…”
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Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics by Luczak, Michal W, Green, Samantha E, Zhitkovich, Anatoly

“…Carcinogenic hexavalent chromium [Cr(VI)] requires cellular reduction to generate DNA damage. Metabolism of Cr(VI) by its principal reducer ascorbate (Asc)…”
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