Search Results - "Luckman, Simon M."

Ventromedial Nucleus of the Hypothalamus Neurons Under the Magnifying Glass by Khodai, Tansi, Luckman, Simon M

“…The ventromedial nucleus of the hypothalamus (VMH) is a complex brain structure that is integral to many neuroendocrine functions, including glucose…”
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The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus by Dodd, Garron T., Worth, Amy A., Nunn, Nicolas, Korpal, Aaron K., Bechtold, David A., Allison, Margaret B., Myers, Martin G., Statnick, Michael A., Luckman, Simon M.

“…Leptin is a critical regulator of metabolism, which acts on brain receptors (Lepr) to reduce energy intake and increase energy expenditure. Some of the…”
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Do oxytocin neurones affect feeding? by Worth, Amy A., Luckman, Simon M.

“…There has been a long history of research on the effects of oxytocin on feeding behaviour. The classic‐held view is that the neurohormone is anorexigenic at…”
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The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling by Worth, Amy A, Shoop, Rosemary, Tye, Katie, Feetham, Claire H, D'Agostino, Giuseppe, Dodd, Garron T, Reimann, Frank, Gribble, Fiona M, Beebe, Emily C, Dunbar, James D, Alexander-Chacko, Jesline T, Sindelar, Dana K, Coskun, Tamer, Emmerson, Paul J, Luckman, Simon M

“…The cytokine, GDF15, is produced in pathological states which cause cellular stress, including cancer. When over expressed, it causes dramatic weight…”
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A Role for the Melatonin-Related Receptor GPR50 in Leptin Signaling, Adaptive Thermogenesis, and Torpor by Bechtold, David A., Sidibe, Anissa, Saer, Ben R.C., Li, Jian, Hand, Laura E., Ivanova, Elena A., Darras, Veerle M., Dam, Julie, Jockers, Ralf, Luckman, Simon M., Loudon, Andrew S.I.

“…The ability of mammals to maintain a constant body temperature has proven to be a profound evolutionary advantage, allowing members of this class to thrive in…”
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The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors by Cook, Chris, Nunn, Nicolas, Worth, Amy A, Bechtold, David A, Suter, Todd, Gackeheimer, Susan, Foltz, Lisa, Emmerson, Paul J, Statnick, Michael A, Luckman, Simon M

“…Here we show that central administration of pyroglutamylated arginine-phenylamine-amide peptide (QRFP/26RFa) increases both food intake and locomotor activity,…”
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Glucose-sensing neurons of the hypothalamus by Burdakov, Denis, Luckman, Simon M, Verkhratsky, Alexei

“…pump, or activation of a hyperpolarizing Cl…”
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Paraventricular oxytocin neurons impact energy intake and expenditure: projections to the bed nucleus of the stria terminalis reduce sucrose consumption by Worth, Amy A, Feetham, Claire H, Morrissey, Nicole A, Luckman, Simon M

“…The part played by oxytocin and oxytocin neurons in the regulation of food intake is controversial. There is much pharmacological data to support a role for…”
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Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation by Costa, Alessia, Ai, Minrong, Nunn, Nicolas, Culotta, Isabella, Hunter, Jenna, Boudjadja, Mehdi Boutagouga, Valencia-Torres, Lourdes, Aviello, Gabriella, Hodson, David J., Snider, Brandy M., Coskun, Tamer, Emmerson, Paul J., Luckman, Simon M., D'Agostino, Giuseppe

“…Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective medications to reduce appetite and body weight. These actions are centrally mediated;…”
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A rare human variant that disrupts GPR10 signalling causes weight gain in mice by Talbot, Fleur, Feetham, Claire H., Mokrosiński, Jacek, Lawler, Katherine, Keogh, Julia M., Henning, Elana, Mendes de Oliveira, Edson, Ayinampudi, Vikram, Saeed, Sadia, Bonnefond, Amélie, Arslan, Mohammed, Yeo, Giles S. H., Froguel, Philippe, Bechtold, David A., Adamson, Antony, Humphreys, Neil, Barroso, Inês, Luckman, Simon M., Farooqi, I. Sadaf

“…Disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with…”
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The role of RFamide peptides in feeding by Bechtold, David A, Luckman, Simon M

“…In the three decades since FMRFamide was isolated from the clam Macrocallista nimbosa, the list of RFamide peptides has been steadily growing. These peptides…”
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PACAP Neurons in the Hypothalamic Ventromedial Nucleus Are Targets of Central Leptin Signaling by Hawke, Zoe, Ivanov, Tina R, Bechtold, David A, Dhillon, Harveen, Lowell, Brad B, Luckman, Simon M

“…The adipose-derived hormone, leptin, was discovered over 10 years ago, but only now are we unmasking its downstream pathways which lead to reduced energy…”
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PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia by Khodai, Tansi, Nunn, Nicolas, Worth, Amy A, Feetham, Claire H, Belle, Mino D C, Piggins, Hugh D, Luckman, Simon M

“…Glucose-sensing neurons are located in several parts of the brain, but are concentrated in the ventromedial nucleus of the hypothalamus (VMH). The importance…”
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Physiological Roles of GPR10 and PrRP Signaling by Dodd, Garron T, Luckman, Simon M

“…Prolactin-releasing peptide (PrRP) was first isolated from bovine hypothalamus, and was found to act as an endogenous ligand at the G-protein-coupled receptor…”
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Acute Central Ghrelin and GH Secretagogues Induce Feeding and Activate Brain Appetite Centers by Lawrence, Catherine B, Snape, Amelie C, Baudoin, Florence M.-H, Luckman, Simon M

“…Ghrelin was recently identified as the endogenous ligand for the GH secretagogue (GHS) receptor. Like the synthetic GHSs[ e.g. GH-releasing peptide-6…”
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Prolactin-Releasing Peptide Mediates Cholecystokinin-Induced Satiety in Mice by Bechtold, David A, Luckman, Simon M

“…We have shown previously that prolactin-releasing peptide (PrRP) plays a role in the regulation of feeding and energy expenditure in rats. We hypothesize that…”
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Gene Regulation in the Magnocellular Hypothalamo-Neurohypophysial System by Burbach, J. Peter H, Luckman, Simon M, Murphy, David, Gainer, Harold

“…Rudolf Magnus Institute for Neurosciences, Section of Molecular Neuroscience, Department of Medical Pharmacology, University Medical Center Utrecht, Utrecht,…”
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Metabolic rhythm abnormalities in mice lacking VIP-VPAC2 signaling by Bechtold, David A, Brown, Timothy M, Luckman, Simon M, Piggins, Hugh D

“…The circadian pacemaker in the suprachiasmatic nuclei (SCN) controls endogenous near 24-h physiological and behavioral rhythms in metabolism, neuroendocrine…”
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Effects of Kisspeptin-10 on the Electrophysiological Manifestation of Gonadotropin-Releasing Hormone Pulse Generator Activity in the Female Rat by Kinsey-Jones, James S, Li, Xiao Feng, Luckman, Simon M, O’Byrne, Kevin T

“…Kisspeptins are extraordinarily potent in stimulating gonadotropic hormone secretion via an action on the hypothalamic GnRH neural system. Because the…”
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Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse by Ivanova, Elena A, Bechtold, David A, Dupré, Sandrine M, Brennand, John, Barrett, Perry, Luckman, Simon M, Loudon, Andrew S I

“…The X-linked orphan receptor GPR50 shares 45% homology with the melatonin receptors, yet its ligand and physiological function remain unknown. Here we report…”
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