Search Results - "Luckey, Megan A"

The transcription factor ThPOK suppresses Runx3 and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling by Luckey, Megan A, Kimura, Motoko Y, Waickman, Adam T, Feigenbaum, Lionel, Singer, Alfred, Park, Jung-Hyun

“…Lineage fate in the thymus is imposed by the antagonizing effects of the transcription factors ThPOK and Runx3. Park and colleagues show that ThPOK-induced…”
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Activated T Cells Secrete an Alternatively Spliced Form of Common γ-Chain that Inhibits Cytokine Signaling and Exacerbates Inflammation by Hong, Changwan, Luckey, Megan A., Ligons, Davinna L., Waickman, Adam T., Park, Joo-Young, Kim, Grace Y., Keller, Hilary R., Etzensperger, Ruth, Tai, Xuguang, Lazarevic, Vanja, Feigenbaum, Lionel, Catalfamo, Marta, Walsh, Scott T.R., Park, Jung-Hyun

“…The common γ-chain (γc) plays a central role in signaling by IL-2 and other γc-dependent cytokines. Here we report that activated T cells produce an…”
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Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis by Le Saout, Cecile, Hasley, Rebecca B, Imamichi, Hiromi, Tcheung, Lueng, Hu, Zonghui, Luckey, Megan A, Park, Jung-Hyun, Durum, Scott K, Smith, Mindy, Rupert, Adam W, Sneller, Michael C, Lane, H Clifford, Catalfamo, Marta

“…HIV infection and the associated chronic immune activation alter T cell homeostasis leading to CD4 T cell depletion and CD8 T cell expansion. The mechanisms…”
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The Cytokine Receptor IL-7Rα Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3+ Treg Cells by Waickman, Adam T., Keller, Hilary R., Kim, Tae-Hyoun, Luckey, Megan A., Tai, Xuguang, Hong, Changwan, Molina-París, Carmen, Walsh, Scott T.R., Park, Jung-Hyun

“…IL-7 receptor signaling is essential for the generation and maintenance of conventional T cells. Immunosuppressive Foxp3+ Treg cells, however, express uniquely…”
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Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination by Um, Jee-Hyun, Brown, Alexandra L., Singh, Samarendra K., Chen, Yong, Gucek, Marjan, Lee, Baeck-Seung, Luckey, Megan A., Kim, Myung K., Park, Jung-Hyun, Sleckman, Barry P., Gellert, Martin, Chung, Jay H.

“…The ability to sense metabolic stress is critical for successful cellular adaptation. In eukaryotes, the AMP-activated protein kinase (AMPK), a highly…”
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Intrathymic IL-7: The where, when, and why of IL-7 signaling during T cell development by Hong, Changwan, Luckey, Megan A, Park, Jung-Hyun

“…Highlights ► Immature thymocytes require IL-7 signaling for survival, proliferation, and differentiation. ► IL-7 is produced by thymic stromal cells but not by…”
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Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut by Li, Can, Kim, Hye Kyung, Prakhar, Praveen, Luo, Shunqun, Crossman, Assiatu, Ligons, Davinna L., Luckey, Megan A., Awasthi, Parirokh, Gress, Ronald E., Park, Jung-Hyun

“…The chemokine receptor CCR9 equips T cells with the ability to respond to CCL25, a chemokine that is highly expressed in the thymus and the small intestine…”
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The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells by Keller, Hilary R., Ligons, Davinna L., Li, Can, Hwang, SuJin, Luckey, Megan A., Prakhar, Praveen, Liman, Nurcin, Crossman, Assiatu, Lazarevic, Vanja, Park, Yoo Kyoung, Park, Jung-Hyun

“…Integrin CD103 mediates the adhesion and tissue retention of T cells by binding to E-cadherin which is abundant on epithelial cells. Notably, CD103 is highly…”
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SOCS3 is a suppressor of γc cytokine signaling and constrains generation of murine Foxp3+ regulatory T cells by Luckey, Megan A., Kim, Tae‐Hyoun, Prakhar, Praveen, Keller, Hilary R., Crossman, Assiatu, Choi, Seeyoung, Love, Paul E., Walsh, Scott T.R., Park, Jung‐Hyun

“…SOCS3 is a cytosolic inhibitor of cytokine signaling that suppresses the activation of cytokine receptor‐associated JAK kinases. Mechanistically, SOCS3 is…”
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RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-x L in developing thymocytes by Ligons, Davinna L, Hwang, SuJin, Waickman, Adam T, Park, Joo-Young, Luckey, Megan A, Park, Jung-Hyun

“…The cytokine receptor subunit γc provides critical signals for T cell survival and differentiation. We investigated the molecular mechanism that controls the…”
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Soluble γc cytokine receptor suppresses IL-15 signaling and impairs iNKT cell development in the thymus by Park, Joo-Young, Jo, Yuna, Ko, Eunhee, Luckey, Megan A., Park, Yoo Kyoung, Park, Se-Ho, Park, Jung-Hyun, Hong, Changwan

“…The soluble γc protein (sγc) is a naturally occurring splice isoform of the γc cytokine receptor that is produced by activated T cells and inhibits γc cytokine…”
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γc cytokine signaling: graduate school in thymic education by Luckey, Megan A., Park, Jung-Hyun

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An in vivo IL-7 requirement for peripheral Foxp3+ regulatory T cell homeostasis by Kim, Grace Y, Ligons, Davinna L, Hong, Changwan, Luckey, Megan A, Keller, Hilary R, Tai, Xuguang, Lucas, Philip J, Gress, Ronald E, Park, Jung-Hyun

“…All T cells are dependent on IL-7 for their development and for homeostasis. Foxp3(+) regulatory T cells (Tregs) are unique among T cells in that they are…”
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CD8 Lineage-specific Regulation of Interleukin-7 Receptor Expression by the Transcriptional Repressor Gfi1 by Ligons, Davinna L., Tuncer, Ceren, Linowes, Brett A., Akcay, Izzet Mehmet, Kurtulus, Sema, Deniz, Emre, Atasever Arslan, Belkis, Cevik, Safak Isil, Keller, Hilary R., Luckey, Megan A., Feigenbaum, Lionel, Möröy, Tarik, Ersahin, Tulin, Atalay, Rengul, Erman, Batu, Park, Jung-Hyun

“…Interleukin-7 receptor α (IL-7Rα) is essential for T cell survival and differentiation. Glucocorticoids are potent enhancers of IL-7Rα expression with diverse…”
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Pim1 permits generation and survival of CD4+ T cells in the absence of γc cytokine receptor signaling by Linowes, Brett A., Ligons, Davinna L., Nam, Anna S., Hong, Changwan, Keller, Hilary R., Tai, Xuguang, Luckey, Megan A., Park, Jung‐Hyun

“…γ‐chain (γc) cytokine receptor signaling is required for the development of all lymphocytes. Why γc signaling plays such an essential role is not fully…”
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Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus by Tinsley, Kevin W., Hong, Changwan, Luckey, Megan A., Park, Joo-Young, Kim, Grace Y., Yoon, Hee-won, Keller, Hilary R., Sacks, Andrew J., Feigenbaum, Lionel, Park, Jung-Hyun

“…The zinc-finger protein Ikaros is a key player in T-cell development and a potent tumor suppressor in thymocytes. To understand the molecular basis of its…”
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IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion by Le Saout, Cecile, Luckey, Megan A, Villarino, Alejandro V, Smith, Mindy, Hasley, Rebecca B, Myers, Timothy G, Imamichi, Hiromi, Park, Jung-Hyun, O'Shea, John J, Lane, H Clifford, Catalfamo, Marta

“…IL-7 regulates homeostatic mechanisms that maintain the overall size of the T cell pool throughout life. We show that, under steady-state conditions, IL-7…”
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Interleukin-6 expands homeostatic space for peripheral T cells by Hong, Changwan, Nam, Anna S., Keller, Hilary R., Ligons, Davinna L., Park, Joo-Young, Yoon, Hee-won, Park, Joseph J., Luckey, Megan A., Park, Jung-Hyun

“…•IL-6 signaling downregulates expression of its own receptor.•IL-6 overexpression increases T cell numbers without affecting thymopoiesis.•IL-6 signaling…”
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Enforced Expression of Integrin CD103 on CD4+ T Cells Alters Their Tissue Migration or Residency to Dysregulate Inflammatory Immune Responses in a Mouse Model of Autoimmune Colitis by Keller, Hilary R., Luckey, Megan A., Li, Can, Park, Jung-Hyun

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The transcription factor ThPOK suppresses Runx3 and imposes CD4 super(+) lineage fate by inducing the SOCS suppressors of cytokine signaling by Luckey, Megan A, Kimura, Motoko Y, Waickman, Adam T, Feigenbaum, Lionel, Singer, Alfred, Park, Jung-Hyun

“…Lineage fate in the thymus is determined by mutually exclusive expression of the transcription factors ThPOK and Runx3, with ThPOK imposing the CD4 super(+)…”
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