Search Results - "Luciene B. Vieira"
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Metabotropic glutamate receptors and neurodegenerative diseases
Published in Pharmacological research (01-01-2017)“…[Display omitted] Glutamate is the most important excitatory neurotransmitter of the mammalian central nervous system (CNS), playing an important role in…”
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Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases
Published in Frontiers in pharmacology (23-02-2018)“…Neurodegenerative diseases affect millions of individuals worldwide. So far, no disease-modifying drug is available to treat patients, making the search for…”
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Zika Virus Promotes Neuronal Cell Death in a Non-Cell Autonomous Manner by Triggering the Release of Neurotoxic Factors
Published in Frontiers in immunology (23-08-2017)“…Zika virus (ZIKV) has recently caused a worldwide outbreak of infections associated with severe neurological complications, including microcephaly in infants…”
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Social isolation impairs the persistence of social recognition memory by disturbing the glutamatergic tonus and the olfactory bulb-dorsal hippocampus coupling
Published in Scientific reports (24-01-2019)“…The absence of companion may jeopardize mental health in social animals. Here, we tested the hypothesis that social isolation impairs social recognition memory…”
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Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease
Published in Scientific reports (04-04-2022)“…Obesity represents a global health problem and is characterized by metabolic dysfunctions and a low-grade chronic inflammatory state, which can increase the…”
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Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior
Published in Frontiers in neuroscience (10-02-2021)“…Obesity is a multifactorial disease, which in turn contributes to the onset of comorbidities, such as diabetes and atherosclerosis. Moreover, there are only…”
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A Potential Role for the Ketogenic Diet in Alzheimer's Disease Treatment: Exploring Pre-Clinical and Clinical Evidence
Published in Metabolites (29-12-2023)“…Given the remarkable progress in global health and overall quality of life, the significant rise in life expectancy has become intertwined with the surging…”
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Inhibition of high voltage-activated calcium channels by spider toxin PnTx3-6
Published in The Journal of pharmacology and experimental therapeutics (01-09-2005)“…Animal peptide toxins have become powerful tools to study structure-function relationships and physiological roles of voltage-activated Ca(2+) channels. In the…”
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Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release
Published in Neurotoxicology (Park Forest South) (01-09-2015)“…•Cannabidiol prevented cocaine-induced seizures in mice.•CB1 and CB2 antagonists failed to prevent cannabidiol effects.•Cocaine increases, whereas cannabidiol…”
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10
N-type Ca2+ channels are affected by full-length mutant huntingtin expression in a mouse model of Huntington’s disease
Published in Neurobiology of aging (01-07-2017)“…Abstract Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the amino-terminal region of the…”
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Cholesterol as a key player in the balance of evoked and spontaneous glutamate release in rat brain cortical synaptosomes
Published in Neurochemistry international (01-12-2012)“…► Methyl-β-cyclodextrin induced spontaneous but inhibited the KCl-evoked glutamate release. ► This effect might be upstream to sodium and calcium entry through…”
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The Phoneutria nigriventer spider toxin, PnTx4-5-5, promotes neuronal survival by blocking NMDA receptors
Published in Toxicon (Oxford) (15-03-2016)“…Spider toxins are recognized as useful sources of bioactive substances, showing a wide range of pharmacological effects on neurotransmission. Several spider…”
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Alterations of Calcium Channels in a Mouse Model of Huntington’s Disease and Neuroprotection by Blockage of CaV1 Channels
Published in ASN neuro (01-06-2019)“…Huntington’s disease (HD) is a neurodegenerative autosomal dominant disorder, characterized by symptoms of involuntary movement of the body, loss of cognitive…”
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Peripheral blood mono-nuclear cells derived from Alzheimer's disease patients show elevated baseline levels of secreted cytokines but resist stimulation with β-amyloid peptide
Published in Molecular and cellular neuroscience (01-01-2012)“…Among several other factors, the neuro-toxic β-amyloid peptide (βAP)-induced inflammatory mechanisms have also been implicated in the pathogenesis of…”
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Neuro-transmitters in the central nervous system & their implication in learning and memory processes
Published in Current medicinal chemistry (01-03-2009)“…This review article gives an overview of a number of central neuro-transmitters, which are essential for integrating many functions in the central nervous…”
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Coronary artery bypass surgery provokes Alzheimer's disease-like changes in the cerebrospinal fluid
Published in Journal of Alzheimer's disease (01-01-2010)“…Several biomarkers are used in confirming the diagnosis of cognitive disorders. This study evaluates whether the level of these markers after heart surgery…”
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Transcriptional Analysis of Blood Lymphocytes and Skin Fibroblasts, Keratinocytes, and Endothelial Cells as a Potential Biomarker for Alzheimer's Disease
Published in Journal of Alzheimer's disease (18-10-2016)“…Alzheimer's disease (AD) is a devastating and progressive form of dementia that is typically associated with a build-up of amyloid-β plaques and…”
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All-or-Nothing Type Biphasic Cytokine Production of Human Lymphocytes After Exposure to Alzheimer's β-Amyloid Peptide
Published in Biological psychiatry (1969) (15-11-2008)“…Background Neuro-inflammation, triggered by β-amyloid peptide, is implicated as one of the primary contributors to Alzheimer's disease (AD) pathogenesis, and…”
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Effect of halothane on the release of [Ca2+]i in dorsal root ganglion neurons
Published in Neuroreport (19-05-2004)“…We investigated the effect of the volatile anaesthetic halothane on [Ca]i of dorsal root ganglion neurons. Halothane was able to increase [Ca]i in those…”
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Alterations of Calcium Channels in a Mouse Model of Huntington’s Disease and Neuroprotection by Blockage of Ca V 1 Channels
Published in ASN neuro (01-01-2019)“…Huntington’s disease (HD) is a neurodegenerative autosomal dominant disorder, characterized by symptoms of involuntary movement of the body, loss of cognitive…”
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