A preliminary study of β-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation

A preliminary study of β-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation

The inclusion complex formation between Metoprolol tartarata (MeT) and β-cyclodextrin (β-CD) has been investigated using hyperchromic shift at λ max 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis Vol. 24; no. 5; pp. 871 - 876
Main Authors: Radulovic, D.M., Karljikovic-Rajic, K.D., Lucic, B.M., Vujic, Z.B.
Format: Journal Article Conference Proceeding
Language:English
Published: Amsterdam Elsevier B.V 01-03-2001
Elsevier Science
Subjects:
Analysis
beta-Cyclodextrins
Biological and medical sciences
Chromatography, High Pressure Liquid
Cyclodextrins - chemistry
Cyclodextrins - isolation & purification
Enantiomeric separation
General pharmacology
Inclusion complex
Medical sciences
Metoprolol - chemistry
Metoprolol - isolation & purification
Metoprolol tartrate
Pharmacology. Drug treatments
Spectrophotometry, Ultraviolet
Stereoisomerism
UV-spectrophotometry
β-Cyclodextrin
Metoprolol tartrate
β-Cyclodextrin
Enantiomeric separation
Inclusion complex
UV-spectrophotometry
Separation method
Reversed phase chromatography
Cyclodextrin
Metoprolol
Precolumn
Enantiomer
Oligosaccharide
HPLC chromatography
Inclusion compound
Derivatization
Spectrophotometry
Beta blocking agent
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Summary:The inclusion complex formation between Metoprolol tartarata (MeT) and β-cyclodextrin (β-CD) has been investigated using hyperchromic shift at λ max 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data on usage of MeT/β-CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of β 1-blockers.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(00)00555-0