Search Results - "Luchak, James M."

Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status by Sandulache, Vlad C., Skinner, Heath D., Ow, Thomas J., Zhang, Aijun, Xia, Xuefeng, Luchak, James M., Wong, Lee‐Jun C., Pickering, Curtis R., Zhou, Ge, Myers, Jeffrey N.

“…BACKGROUND: Mutations in the tumor protein 53 (TP53) tumor suppressor gene are common in head and neck squamous cell carcinoma (HNSCC) and correlate with…”
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Overexpression of Glutamate-Cysteine Ligase Extends Life Span in Drosophila melanogaster by Orr, William C., Radyuk, Svetlana N., Prabhudesai, Leena, Toroser, Dikran, Benes, Judith J., Luchak, James M., Mockett, Robin J., Rebrin, Igor, Hubbard, J. Gregory, Sohal, Rajindar S.

“…The hypothesis that overexpression of glutamate-cysteine ligase (GCL), which catalyzes the rate-limiting reaction in de novo glutathione biosynthesis, could…”
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Modulating Longevity in Drosophila by Over- and Underexpression of Glutamate-Cysteine Ligase by LUCHAK, JAMES M., PRABHUDESAI, LEENA, SOHAL, RAJINDAR S., RADYUK, SVETLANA N., ORR, WILLIAM C.

“…:  A notable extension of life span (up to 50%) was achieved in Drosophila melanogaster when the catalytic subunit of glutamate‐cysteine ligase (GCLc) was…”
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The Catalytic Subunit of Drosophila Glutamate-Cysteine Ligase Is a Nucleocytoplasmic Shuttling Protein by Radyuk, Svetlana N., Rebrin, Igor, Luchak, James M., Michalak, Katarzyna, Klichko, Vladimir I., Sohal, Rajindar S., Orr, William C.

“…GSH concentration is considerably lower in the nucleus than in the cytoplasm; however, it is significantly elevated during active cell proliferation. The main…”
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Identification of genes that modify ataxin-1-induced neurodegeneration by Botas, Juan, Fernandez-Funez, Pedro, Nino-Rosales, Maria Laura, de Gouyon, Beatrice, She, Wei-Chi, Luchak, James M, Martinez, Pedro, Turiegano, Enrique, Benito, Jonathan, Capovilla, Maria, Skinner, Pamela J, McCall, Alanna, Canal, Inmaculada, Orr, Harry T, Zoghbi, Huda Y

“…A growing number of human neurodegenerative diseases result from the expansion of a glutamine repeat in the protein that causes the disease. Spinocerebellar…”
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Individualizing anti-metabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status by Sandulache, Vlad C., Skinner, Heath D., Ow, Thomas J., Zhang, Aijun, Xia, Xuefeng, Luchak, James M., Wong, Lee-Jun C., Pickering, Curtis R., Zhou, Ge, Myers, Jeffrey N.

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Longevity effects in Drosophila by modulating glutamate cysteine ligase expression alone and in combination with other longevity associated genes by Luchak, James M

“…A notable extension of life span (up to 50%) was achieved in Drosophila when the catalytic subunit of glutamate-cysteine ligase (GCLc) was over-expressed in…”
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