Search Results - "Lucet, Isabelle S."

The molecular regulation of Janus kinase (JAK) activation by Babon, Jeffrey J, Lucet, Isabelle S, Murphy, James M, Nicola, Nicos A, Varghese, Leila N

“…The JAK (Janus kinase) family members serve essential roles as the intracellular signalling effectors of cytokine receptors. This family, comprising JAK1,…”
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The molecular basis of JAK/STAT inhibition by SOCS1 by Liau, Nicholas P. D., Laktyushin, Artem, Lucet, Isabelle S., Murphy, James M., Yao, Shenggen, Whitlock, Eden, Callaghan, Kimberley, Nicola, Nicos A., Kershaw, Nadia J., Babon, Jeffrey J.

“…The SOCS family of proteins are negative-feedback inhibitors of signalling induced by cytokines that act via the JAK/STAT pathway. SOCS proteins can act as…”
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Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity by Babon, Jeffrey J., Kershaw, Nadia J., Murphy, James M., Varghese, Leila N., Laktyushin, Artem, Young, Samuel N., Lucet, Isabelle S., Norton, Raymond S., Nicola, Nicos A.

“…Janus kinases (JAKs) are key effectors in controlling immune responses and maintaining hematopoiesis. SOCS3 (suppressor of cytokine signaling-3) is a major…”
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Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase by Murphy, James M., Nakatani, Yoshio, Jamieson, Sam A., Dai, Weiwen, Lucet, Isabelle S., Mace, Peter D.

“…CCAAT-enhancer binding proteins (C/EBPs) are transcription factors that play a central role in the differentiation of myeloid cells and adipocytes. Tribbles…”
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Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death by Hildebrand, Joanne M., Tanzer, Maria C., Lucet, Isabelle S., Young, Samuel N., Spall, Sukhdeep K., Sharma, Pooja, Pierotti, Catia, Garnier, Jean-Marc, Dobson, Renwick C.J., Webb, Andrew I., Tripaydonis, Anne, Babon, Jeffrey J., Mulcair, Mark D., Scanlon, Martin J., Alexander, Warren S., Wilks, Andrew F., Czabotar, Peter E., Lessene, Guillaume, Murphy, James M., Silke, John

“…Significance The four-helix bundle (4HB) domain of Mixed Lineage Kinase Domain-Like (MLKL) bears two clusters of residues that are required for cell death by…”
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The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism by Murphy, James M., Czabotar, Peter E., Hildebrand, Joanne M., Lucet, Isabelle S., Zhang, Jian-Guo, Alvarez-Diaz, Silvia, Lewis, Rowena, Lalaoui, Najoua, Metcalf, Donald, Webb, Andrew I., Young, Samuel N., Varghese, Leila N., Tannahill, Gillian M., Hatchell, Esme C., Majewski, Ian J., Okamoto, Toru, Dobson, Renwick C.J., Hilton, Douglas J., Babon, Jeffrey J., Nicola, Nicos A., Strasser, Andreas, Silke, John, Alexander, Warren S.

“…Mixed lineage kinase domain-like (MLKL) is a component of the “necrosome,” the multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell…”
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Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis by Petrie, Emma J., Sandow, Jarrod J., Jacobsen, Annette V., Smith, Brian J., Griffin, Michael D. W., Lucet, Isabelle S., Dai, Weiwen, Young, Samuel N., Tanzer, Maria C., Wardak, Ahmad, Liang, Lung-Yu, Cowan, Angus D., Hildebrand, Joanne M., Kersten, Wilhelmus J. A., Lessene, Guillaume, Silke, John, Czabotar, Peter E., Webb, Andrew I., Murphy, James M.

“…Necroptotic cell death is mediated by the most terminal known effector of the pathway, MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain…”
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SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition by Kershaw, Nadia J, Murphy, James M, Liau, Nicholas P D, Varghese, Leila N, Laktyushin, Artem, Whitlock, Eden L, Lucet, Isabelle S, Nicola, Nicos A, Babon, Jeffrey J

“…The inhibitory protein SOCS3 plays a key part in hematopoiesis by regulating signaling induced by specific cytokines. The crystal structure of SOCS3 bound to…”
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A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties by Murphy, James M, Zhang, Qingwei, Young, Samuel N, Reese, Michael L, Bailey, Fiona P, Eyers, Patrick A, Ungureanu, Daniela, Hammaren, Henrik, Silvennoinen, Olli, Varghese, Leila N, Chen, Kelan, Tripaydonis, Anne, Jura, Natalia, Fukuda, Koichi, Qin, Jun, Nimchuk, Zachary, Mudgett, Mary Beth, Elowe, Sabine, Gee, Christine L, Liu, Ling, Daly, Roger J, Manning, Gerard, Babon, Jeffrey J, Lucet, Isabelle S

“…Protein kinase-like domains that lack conserved residues known to catalyse phosphoryl transfer, termed pseudokinases, have emerged as important signalling…”
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Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance by Garcia, Laura Ramos, Tenev, Tencho, Newman, Richard, Haich, Rachel O., Liccardi, Gianmaria, John, Sidonie Wicky, Annibaldi, Alessandro, Yu, Lu, Pardo, Mercedes, Young, Samuel N., Fitzgibbon, Cheree, Fernando, Winnie, Guppy, Naomi, Kim, Hyojin, Liang, Lung-Yu, Lucet, Isabelle S., Kueh, Andrew, Roxanis, Ioannis, Gazinska, Patrycja, Sims, Martin, Smyth, Tomoko, Ward, George, Bertin, John, Beal, Allison M., Geddes, Brad, Choudhary, Jyoti S., Murphy, James M., Aurelia Ball, K., Upton, Jason W., Meier, Pascal

“…Necroptosis is a lytic, inflammatory form of cell death that not only contributes to pathogen clearance but can also lead to disease pathogenesis. Necroptosis…”
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Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3 by Petrie, Emma J., Sandow, Jarrod J., Lehmann, Wil I.L., Liang, Lung-Yu, Coursier, Diane, Young, Samuel N., Kersten, Wilhelmus J.A., Fitzgibbon, Cheree, Samson, André L., Jacobsen, Annette V., Lowes, Kym N., Au, Amanda E., Jousset Sabroux, Hélène, Lalaoui, Najoua, Webb, Andrew I., Lessene, Guillaume, Manning, Gerard, Lucet, Isabelle S., Murphy, James M.

“…Necroptotic cell death has been implicated in many human pathologies and is thought to have evolved as an innate immunity mechanism. The pathway relies on two…”
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Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1 by Patel, Onisha, Dai, Weiwen, Mentzel, Mareike, Griffin, Michael D.W., Serindoux, Juliette, Gay, Yoann, Fischer, Stefanie, Sterle, Shoukat, Kropp, Ashleigh, Burns, Christopher J., Ernst, Matthias, Buchert, Michael, Lucet, Isabelle S.

“…Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that belongs to the family of microtubule-associated proteins. Originally identified for its…”
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Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues by Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Yeung, Wayland, Coursier, Diane, Birkinshaw, Richard W., Sandow, Jarrod J., Lehmann, Wil I. L., Liang, Lung-Yu, Lucet, Isabelle S., Chalmers, James D., Patrick, Wayne M., Kannan, Natarajan, Petrie, Emma J., Czabotar, Peter E., Murphy, James M.

“…The MLKL pseudokinase is the terminal effector in the necroptosis cell death pathway. Phosphorylation by its upstream regulator, RIPK3, triggers MLKL’s…”
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FSHD2- and BAMS-associated mutations confer opposing effects on SMCHD1 function by Gurzau, Alexandra D., Chen, Kelan, Xue, Shifeng, Dai, Weiwen, Lucet, Isabelle S., Ly, Thanh Thao Nguyen, Reversade, Bruno, Blewitt, Marnie E., Murphy, James M.

“…Structural maintenance of chromosomes flexible hinge domain-containing 1 (Smchd1) plays important roles in epigenetic silencing and normal mammalian…”
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Regulation of Janus kinases by SOCS proteins by Kershaw, Nadia J, Murphy, James M, Lucet, Isabelle S, Nicola, Nicos A, Babon, Jeffrey J

“…JAKs (Janus kinases) are essential mediators of almost all biological signalling events initiated by haemopoietic and immune cytokines. However, aberrant…”
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Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL by Murphy, James M, Lucet, Isabelle S, Hildebrand, Joanne M, Tanzer, Maria C, Young, Samuel N, Sharma, Pooja, Lessene, Guillaume, Alexander, Warren S, Babon, Jeffrey J, Silke, John, Czabotar, Peter E

“…The pseudokinase MLKL (mixed lineage kinase domain-like) was identified recently as an essential checkpoint in the programmed necrosis or 'necroptosis' cell…”
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Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling by Roy, Michael J., Surudoi, Minglyanna G., Kropp, Ashleigh, Hou, Jianmei, Dai, Weiwen, Hardy, Joshua M., Liang, Lung-Yu, Cotton, Thomas R., Lechtenberg, Bernhard C., Dite, Toby A., Ma, Xiuquan, Daly, Roger J., Patel, Onisha, Lucet, Isabelle S.

“…PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key signaling proteins to the cytoskeleton. Despite lacking catalytic…”
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Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association by Patel, Onisha, Griffin, Michael D. W., Panjikar, Santosh, Dai, Weiwen, Ma, Xiuquan, Chan, Howard, Zheng, Celine, Kropp, Ashleigh, Murphy, James M., Daly, Roger J., Lucet, Isabelle S.

“…The mammalian pseudokinase SgK223, and its structurally related homologue SgK269, are oncogenic scaffolds that nucleate the assembly of specific signalling…”
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The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain by Chen, Kelan, Dobson, Renwick C J, Lucet, Isabelle S, Young, Samuel N, Pearce, F Grant, Blewitt, Marnie E, Murphy, James M

“…Structural maintenance of chromosomes flexible hinge domain containing 1 (Smchd1) is an epigenetic regulator that plays critical roles in gene regulation…”
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Dissecting Specificity in the Janus Kinases: The Structures of JAK-Specific Inhibitors Complexed to the JAK1 and JAK2 Protein Tyrosine Kinase Domains by Williams, Neal K., Bamert, Rebecca S., Patel, Onisha, Wang, Christina, Walden, Patricia M., Wilks, Andrew F., Fantino, Emmanuelle, Rossjohn, Jamie, Lucet, Isabelle S.

“…The Janus kinases (JAKs) are a pivotal family of protein tyrosine kinases (PTKs) that play prominent roles in numerous cytokine signaling pathways, with…”
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