Microalbuminuria and associated clinical features among Brazilians with insulin dependent diabetes mellitus

With the objective to determine the frequency of microalbuminuria, macroalbuminuria and the associated clinic and metabolic features among insulin dependent diabetes mellitus (IDDM) Brazilian patients attending at a general University Hospital, a total of 50 outpatients, aged 21.9 ± 7 years with IDD...

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Bibliographic Details
Published in:	Diabetes research and clinical practice Vol. 35; no. 2; pp. 143 - 147
Main Authors:	Gomes, Marilia B., Lucchetti, Marcelo Ruiz, Gazzola, Helena, Dimetz, Trude, Gonçalves, Maria Fatima, Neves, Ricardo, Matos, Haroldo
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 01-03-1997 Elsevier Science
Subjects:	Adult Albuminuria - epidemiology Albuminuria - urine Associated diseases and complications Biological and medical sciences Blood Pressure Brazil - epidemiology Cohort Studies Cross-Sectional Studies Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - physiopathology Diabetes Mellitus, Type 1 - urine Diabetes. Impaired glucose tolerance Diabetic Nephropathies - epidemiology Diabetic Nephropathies - urine Diabetic Retinopathy - diagnosis Diabetic Retinopathy - epidemiology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Humans Hypertension - diagnosis Hypertension - epidemiology IDDM Male Medical sciences Microalbuminuria Prevalence Regression Analysis Retinopathy Brazil SBP Retinopathy DBP AMBP IDDM FBG HBA 1 Microalbuminuria AER BMI Endocrinopathy Human Immunopathology Urinary system disease Diabetes mellitus Albumin Autoimmune disease Body mass index Symptomatology Eye disease Association Insulin dependent diabetes Complication Frequency Clinical investigation Glycemia Proteinuria
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Summary:	With the objective to determine the frequency of microalbuminuria, macroalbuminuria and the associated clinic and metabolic features among insulin dependent diabetes mellitus (IDDM) Brazilian patients attending at a general University Hospital, a total of 50 outpatients, aged 21.9 ± 7 years with IDDM duration of 6.8 ± 5.8 years were studied cross-sectionally. Urinary albumin excretion rate (AER) was determined in timed overnight urine samples. Microalbuminuria was defined when two out of three urine samples had AER ranging 20–200 μg/min. Microalbuminuria was present in 12% of our patients. No macroalbuminuric patient was found. Among patients with diabetes duration ≤ 5 years ( n = 24), 8,3% ( n = 2) had microalbuminuria. Retinopathy was strongly associated with microalbuminuria ( P = 0.004) although no proliferative retinopathy was noted. No difference was observed concerning FBG and HBA1 between normo and microalbuminuric patients. Univariate analysis has revealed no influence of these variables in AER. Systolic blood pressure (sBP) was high in microalbuminuric patients and stepwise multiple regression analysis has shown that it was the only significant independent variable to influence AER. ( R = 0.42 r 2 = 0.18 P = 0.002). In conclusion, the frequency of microalbuminuria in this sample of IDDM Brazilian patients was similar to other populational groups and was associated with retinopathy and sBP.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0168-8227 1872-8227
DOI:	10.1016/S0168-8227(97)01368-5