Search Results - "Lucas, Jose J."

GSK3 and tau: two convergence points in Alzheimer's disease by Hernandez, Felix, Lucas, Jose J, Avila, Jesus

“…Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed serine/threonine kinase that plays a key role in the pathogenesis of Alzheimer's disease (AD)…”
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NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy by Gómez-Sintes, Raquel, Lucas, José J

“…Use of lithium, the mainstay for treatment of bipolar disorder, is limited by its frequent neurological side effects and its risk for overdose-induced…”
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Full Reversal of Alzheimer's Disease-Like Phenotype in a Mouse Model with Conditional Overexpression of Glycogen Synthase Kinase-3 by Engel, Tobias, Hernandez, Felix, Avila, Jesus, Lucas, Jose J

“…Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase that is particularly abundant in the CNS. Dysregulation of GSK-3…”
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Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome by Arranz, Juan, Balducci, Elisa, Arató, Krisztina, Sánchez-Elexpuru, Gentzane, Najas, Sònia, Parras, Alberto, Rebollo, Elena, Pijuan, Isabel, Erb, Ionas, Verde, Gaetano, Sahun, Ignasi, Barallobre, Maria J., Lucas, José J., Sánchez, Marina P., de la Luna, Susana, Arbonés, Maria L.

“…Autism spectrum disorders are early onset neurodevelopmental disorders characterized by deficits in social communication and restricted repetitive behaviors,…”
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N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation by Goñi-Oliver, Paloma, Lucas, José J, Avila, Jesús, Hernández, Félix

“…Although GSK-3 activity can be regulated by phosphorylation and through interaction with GSK-3-binding proteins, here we describe N-terminal proteolysis as a…”
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Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease by BLAZQUEZ, Cristina, CHIARLONE, Anna, BENITO, Cristina, CARRASCO, Carolina, DIEZ-ZAERA, María, PAOLETTI, Paola, DIAZ-HERNANDEZ, Miguel, RUIZ, Carolina, SENDTNER, Michael, LUCAS, José J, DE YEBENES, Justo G, MARSICANO, Giovanni, SAGREDO, Onintza, MONORY, Krisztina, LUTZ, Beat, ROMERO, Julián, ALBERCH, Jordi, GINES, Silvia, KRAUS, Jürgen, FERNANDEZ-RUIZ, Javier, GALVE-ROPERH, Ismael, GUZMAN, Manuel, AGUADO, Tania, RUTH PAZOS, M, RESEL, Eva, PALAZUELOS, Javier, JULIEN, Boris, SALAZAR, María, BÖRNER, Christine

“…Endocannabinoids act as neuromodulatory and neuroprotective cues by engaging type 1 cannabinoid receptors. These receptors are highly abundant in the basal…”
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Neuronal apoptosis and motor deficits in mice with genetic inhibition of GSK-3 are Fas-dependent by Gómez-Sintes, Raquel, Lucas, José J

“…Glycogen synthase kinase-3 (GSK-3) inhibitors have been postulated as useful therapeutic tools for the treatment of chronic neurodegenerative and…”
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GSK-3 Mouse Models to Study Neuronal Apoptosis and Neurodegeneration by Gómez-Sintes, Raquel, Hernández, Félix, Lucas, José J, Avila, Jesús

“…Increased GSK-3 activity is believed to contribute to the etiology of chronic disorders like Alzheimer's disease (AD), schizophrenia, diabetes, and some types…”
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α-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease by Tomás-Zapico, Cristina, Díez-Zaera, María, Ferrer, Isidre, Gómez-Ramos, Pilar, Morán, María A., Miras-Portugal, M. Teresa, Díaz-Hernández, Miguel, Lucas, José J.

“…Huntington's disease (HD) is the most common of nine inherited neurological disorders caused by expanded polyglutamine (polyQ) sequences which confer…”
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Impaired ATF6α processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease by Fernandez-Fernandez, Maria Rosario, Ferrer, Isidro, Lucas, Jose J

“…Abstract The endoplasmic reticulum-stress response is induced in several neurodegenerative diseases and in cellular models of Huntington's disease. However,…”
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Structural Insights and Biological Effects of Glycogen Synthase Kinase 3-specific Inhibitor AR-A014418 by Bhat, Ratan, Xue, Yafeng, Berg, Stefan, Hellberg, Sven, Ormö, Mats, Nilsson, Yvonne, Radesäter, Ann-Cathrin, Jerning, Eva, Markgren, Per-Olof, Borgegård, Thomas, Nylöf, Martin, Giménez-Cassina, Alfredo, Hernández, Félix, Lucas, Jose J., Díaz-Nido, Javier, Avila, Jesús

“…Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer's disease. We…”
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CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in huntington's disease by Yu, Dahyun, Zarate, Nicole, White, Angel, Coates, De'jah, Tsai, Wei, Nanclares, Carmen, Cuccu, Francesco, Yue, Johnny S, Brown, Taylor G, Mansky, Rachel H, Jiang, Kevin, Kim, Hyuck, Nichols-Meade, Tessa, Larson, Sarah N, Gundry, Katherine, Zhang, Ying, Tomas-Zapico, Cristina, Lucas, Jose J, Benneyworth, Michael, Öz, Gülin, Cvetanovic, Marija, Araque, Alfonso, Gomez-Pastor, Rocio

“…Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the HTT gene for which no therapies are available…”
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Cooexpression of FTDP-17 tau and GSK-3β in transgenic mice induce tau polymerization and neurodegeneration by Engel, Tobias, Lucas, José J., Gómez-Ramos, Pilar, Moran, María A., Ávila, Jesús, Hernández, Félix

“…Here we have tested whether tau modification either by point mutation or by hyperphosphorylation can exert maximal pathogenic effects or if, on the contrary,…”
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Accumulation of Ubiquitin Conjugates in a Polyglutamine Disease Model Occurs without Global Ubiquitin/Proteasome System Impairment by Maynard, Christa J., Böttcher, Claudia, Ortega, Zaira, Smith, Ruben, Florea, Bogdan I., Díaz-Hernández, Miguel, Brundin, Patrik, Overkleeft, Hermen S., Li, Jia-Yi, Lucas, Jose J., Dantuma, Nico P., Zoghbi, Huda Y.

“…Aggregation-prone proteins have been suggested to overwhelm and impair the ubiquitin/proteasome system (UPS) in polyglutamine (polyQ) disorders, such as…”
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Correction to: CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease by Yu, Dahyun, Zarate, Nicole, White, Angel, Coates, De'jah, Tsai, Wei, Nanclares, Carmen, Cuccu, Francesco, Yue, Johnny S, Brown, Taylor G, Mansky, Rachel H, Jiang, Kevin, Kim, Hyuck, Nichols-Meade, Tessa, Larson, Sarah N, Gundry, Katherine, Zhang, Ying, Tomas-Zapico, Cristina, Lucas, Jose J, Benneyworth, Michael, üz, Gülin, Cvetanovic, Marija, Araque, Alfonso, Gomez-Pastor, Rocio

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Tau phosphorylation in hippocampus results in toxic gain-of-function by Avila, Jesús, Gómez de Barreda, Elena, Engel, Tobias, Lucas, Jose J, Hernández, Félix

“…The MAP (microtubule-associated protein) tau binds to tubulin, the main component of MTs (microtubules), which results in the stabilization of MT polymers. Tau…”
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Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome by Hernández-Ortega, Karina, Garcia-Esparcia, Paula, Gil, Laura, Lucas, José J., Ferrer, Isidre

“…Ribosomes and protein synthesis have been reported to be altered in the cerebral cortex at advanced stages of Alzheimer's disease (AD). Modifications in the…”
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Looking for novel functions of tau by Avila, Jesus, de Barreda, Elena Gomez, Fuster-Matanzo, Almudena, Simón, Diana, Llorens-Martín, María, Engel, Tobias, Lucas, Jose J, Díaz-Hernández, Miguel, Hernández, Félix

“…The lack or excess of the protein tau can be deleterious for neurons. The absence of tau can result in retarded neurogenesis and neuronal differentiation,…”
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α-synuclein levels affect autophagosome numbers in vivo and modulate Huntington disease pathology by Corrochano, Silvia, Renna, Maurizio, Tomas-Zapico, Cristina, Brown, Steve D.M., Lucas, Jose J., Rubinsztein, David C., Acevedo-Arozena, Abraham

“…Huntington and Parkinson diseases (HD and PD) are two major neurodegenerative disorders pathologically characterized by the accumulation of the aggregate-prone…”
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Proteasomal Expression, Induction of Immunoproteasome Subunits, and Local MHC Class I Presentation in Myofibrillar Myopathy and Inclusion Body Myositis by FERRER, ISIDRO, MARTÍN, BEGOÑA, CASTAÑO, JOSÉ G, LUCAS, JOSÉ J, MORENO, DOLORES, OLIVÉ, MONTSE

“…Inclusion body myositis (IBM) and myofibrillar myopathy (MM) are diseases characterized by the abnormal accumulation of proteins in muscle fibers, including…”
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