Search Results - "Lucas, Jose"
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GSK3 and tau: two convergence points in Alzheimer's disease
Published in Journal of Alzheimer's disease (01-01-2013)“…Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed serine/threonine kinase that plays a key role in the pathogenesis of Alzheimer's disease (AD)…”
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2
Excited-state proton transfer relieves antiaromaticity in molecules
Published in Proceedings of the National Academy of Sciences - PNAS (08-10-2019)“…Baird’s rule explains why and when excited-state proton transfer (ESPT) reactions happen in organic compounds. Bifunctional compounds that are [4n + 2]…”
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NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy
Published in The Journal of clinical investigation (01-07-2010)“…Use of lithium, the mainstay for treatment of bipolar disorder, is limited by its frequent neurological side effects and its risk for overdose-induced…”
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4
Oxidative stress as an underlying contributor in the development of chronic complications in diabetes mellitus
Published in International Journal of Molecular Sciences (05-02-2013)“…The high prevalence of diabetes mellitus and its increasing incidence worldwide, coupled with several complications observed in its carriers, have become a…”
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Preparation of environmental samples for chemical speciation of metal/metalloids: A review of extraction techniques
Published in Talanta (Oxford) (01-05-2021)“…Chemical speciation is a relevant topic in environmental chemistry since the (eco)toxicity, bio (geo)chemical cycles, and mobility of a given element depend on…”
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Full Reversal of Alzheimer's Disease-Like Phenotype in a Mouse Model with Conditional Overexpression of Glycogen Synthase Kinase-3
Published in The Journal of neuroscience (10-05-2006)“…Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase that is particularly abundant in the CNS. Dysregulation of GSK-3…”
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Rationalizing the conversion of glucose and xylose catalyzed by a combination of Lewis and Brønsted acids
Published in Catalysis today (15-03-2020)“…[Display omitted] •Glucose conversion: Nb2O5 acts as a Lewis acid forming mannose and fructose.•High HMF yields: when Nb2O5 is associated to an additional…”
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The Impact of the Ratio Between Stronger and Weaker Acid Sites on the Production of 5‐Hydroxymethylfurfural and Furfural from Monosaccharides
Published in ChemCatChem (08-07-2024)“…Sulfonated carbons and commercial Amberlyst 15 and 45 served as model catalysts to explore the impact of the ratio between stronger and weaker acid sites…”
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Retrospective assessment of patients' risk for peri‐implant diseases using the implant disease risk assessment (IDRA) tool: A cohort study
Published in Clinical implant dentistry and related research (01-10-2024)“…Introduction The implant disease risk assessment (IDRA) tool was designed to assess an individual's risk of developing peri‐implant diseases by evaluating and…”
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Elucidating the action mechanisms of silicon in the mitigation of phosphorus deficiency and enhancement of its response in sorghum plants
Published in Journal of plant nutrition (21-10-2021)“…Phosphorus (P) is one of the most limiting nutrients in agricultural production and silicon (Si) application is a strategy used to improve phosphate nutrition…”
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Genomic comparisons and phylogenetic analysis of mastitis-related staphylococci with a focus on adhesion, biofilm, and related regulatory genes
Published in Scientific reports (30-08-2021)“…Mastitis is a common and costly disease on dairy farms, commonly caused by Staphylococcus spp. though the various species are associated with different…”
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Niobium phosphates as bifunctional catalysts for the conversion of biomass-derived monosaccharides
Published in Applied catalysis. A, General (05-05-2021)“…[Display omitted] •The synthesis method affects the chemical composition of the niobium phosphate.•The reaction rate increases as the P/Nb ratio…”
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Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients : Increase in Lipid Peroxidation and SOD Activity
Published in Oxidative medicine and cellular longevity (01-01-2012)“…This study evaluated the oxidative stress through enzymatic and nonenzymatic biomarkers in diabetic patients with and without hypertension and prediabetics…”
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Can sterilization methods influence surface properties of resin composites? A purpose for previewing bias in laboratory bacterial adhesion tests
Published in Microscopy research and technique (01-03-2022)“…This study aimed to evaluate the influence of sterilization methods on conventional and bulk‐fill resin composites' (BFRCs) surface properties in an attempt to…”
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N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation
Published in The Journal of biological chemistry (03-08-2007)“…Although GSK-3 activity can be regulated by phosphorylation and through interaction with GSK-3-binding proteins, here we describe N-terminal proteolysis as a…”
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Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease
Published in Brain (London, England : 1878) (01-01-2011)“…Endocannabinoids act as neuromodulatory and neuroprotective cues by engaging type 1 cannabinoid receptors. These receptors are highly abundant in the basal…”
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Enhancing tomato plant resistance to pathogens: the role of melatonin in boosting innate immunity and antioxidant defences
Published in Plant growth regulation (24-10-2024)Get full text
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Robust Guidance Strategy for Target Circulation by Controlled UAV
Published in IEEE transactions on aerospace and electronic systems (01-06-2018)“…A controlled fixed-wing unmanned aerial vehicle is modeled as a simplified low-dimensional nonlinear dynamical system with additive disturbances. The guidance…”
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Deep Deterministic Policy Gradient-Based Resource Allocation Considering Network Slicing and Device-to-Device Communication in Mobile Networks
Published in Sensors (Basel, Switzerland) (20-09-2024)“…Next-generation mobile networks, such as those beyond the 5th generation (B5G) and 6th generation (6G), have diverse network resource demands. Network slicing…”
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Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome
Published in Neurobiology of disease (01-07-2019)“…Autism spectrum disorders are early onset neurodevelopmental disorders characterized by deficits in social communication and restricted repetitive behaviors,…”
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