Search Results - "Lucas, John C."

Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors by Huard, Kim, Bagley, Scott W, Menhaji-Klotz, Elnaz, Préville, Cathy, Southers, James A, Smith, Aaron C, Edmonds, David J, Lucas, John C, Dunn, Matthew F, Allanson, Nigel M, Blaney, Emma L, Garcia-Irizarry, Carmen N, Kohrt, Jeffrey T, Griffith, David A, Dow, Robert L

“…The synthesis of 4′,6′-dihydrospiro[piperidine-4,5′-pyrazolo[3,4-c]pyridin]-7′(2′H)-one-based acetyl-CoA carboxylase inhibitors is reported. The hitherto…”
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Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease by Helal, Christopher J., Sanner, Mark A., Cooper, Christopher B., Gant, Thomas, Adam, Mavis, Lucas, John C., Kang, Zhijun, Kupchinsky, Stanley, Ahlijanian, Michael K., Tate, Bonnie, Menniti, Frank S., Kelly, Kristin, Peterson, Marcia

“…[Display omitted] High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide ( 1)…”
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Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease by Helal, Christopher J., Kang, Zhijun, Lucas, John C., Gant, Thomas, Ahlijanian, Michael K., Schachter, Joel B., Richter, Karl E.G., Cook, James M., Menniti, Frank S., Kelly, Kristin, Mente, Scot, Pandit, Jay, Hosea, Natalie

“…Utilizing structure-based drug design, a 4-aminoimidazole heterocyclic core was synthesized as a replacement for a 2-aminothiazole due to potential…”
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A Concise and Regioselective Synthesis of 1-Alkyl-4-imidazolecarboxylates by Helal, Christopher J, Lucas, John C

“…Reaction between ethyl 3-N,N-(dimethylamino)-2-isocyanoacrylate (1) and a primary amine (2) regioselectively affords 1-alkyl-4-imidazolecarboxylates (3) in…”
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Stereoselective Synthesis of cis-1,3-Disubstituted Cyclobutyl Kinase Inhibitors by Helal, Christopher J, Kang, Zhijun, Lucas, John C, Bohall, Brooks R

“…Two synthetic routes to a series of structurally novel kinase inhibitors containing a cis-1,3-disubstituted cyclobutane are described. The first route utilized…”
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Stereoselective Synthesis of 1,3-Disubstituted Cyclobutyl Kinase Inhibitors by Helal, Christopher J, Kang, Zhijun, Lucas, John C, Bohall, Brooks R

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The Drainage of Bombay by Lucas, John C

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The Treatment of Typhoid Fever by Lucas, John C

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The Treatment of the Uric Acid Diathesis by Lucas, John C

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The Treatment of Leprosy with Gurjun Oil by Lucas, John C

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A Case of Hepatic Abscess, with Remarks by Lucas, John C

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The Hygiene and Etiological Import of Relapse in Enteric Fever: And Dr. Irvine by Lucas, John C

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Notes on Enteric Fever or Abdominal Typhus, with Remarks on Enteric Fever in Afghanistan and on a Case Occurring There by Lucas, John C

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Ferruginous Compounds in Sewage-Antisepsis by Lucas, John C

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Croup and Diphtheria by Lucas, John C

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Croup and Diphtheria by Lucas, John C

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Pneumatic Aspiration; Puncture of Parenchymatous Organs; Direct Depletion by Lucas, John C

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"The Functional(?) Derangement of the Circulatory System in European Soldiers in the Hot Weather by Lucas, John C

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Salicin, Salicylic Acid and Its Salts by Lucas, John C

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On Syphilitic Contraction of Muscles by Lucas, John C

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