Search Results - "Lucas, James"

New computational protein design methods for de novo small molecule binding sites by Lucas, James E, Kortemme, Tanja

“…Protein binding to small molecules is fundamental to many biological processes, yet it remains challenging to predictively design this functionality de novo…”
Get full text

Systems of Communication: Aspects of Culture and Structure in Speech Surrogates by James, Lucas

“…The practice of speech surrogacy is used for communication across many cultures. Previous work has historically engaged with the study of speech surrogates as…”
Get full text

Flex ddG: Rosetta Ensemble-Based Estimation of Changes in Protein–Protein Binding Affinity upon Mutation by Barlow, Kyle A, Ó Conchúir, Shane, Thompson, Samuel, Suresh, Pooja, Lucas, James E, Heinonen, Markus, Kortemme, Tanja

“…Computationally modeling changes in binding free energies upon mutation (interface ΔΔG) allows large-scale prediction and perturbation of protein–protein…”
Get full text

COVID‐19 distress and worries: The role of attitudes, social support, and positive coping during social isolation by Moore, Kathleen A., Lucas, James J.

“…As the COVID‐19 pandemic accelerates, one public health response has been for governments to impose quarantine ‘lockdowns’ which require people to socially…”
Get full text

Psychological flexibility: positive implications for mental health and life satisfaction by Lucas, James J, Moore, Kathleen A

“…New wave therapies such as Acceptance and Commitment Therapy aim to cultivate people's psychological flexibility in order for them to live a satisfying life…”
Get full text

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs by Kundert, Kale, Lucas, James E., Watters, Kyle E., Fellmann, Christof, Ng, Andrew H., Heineike, Benjamin M., Fitzsimmons, Christina M., Oakes, Benjamin L., Qu, Jiuxin, Prasad, Neha, Rosenberg, Oren S., Savage, David F., El-Samad, Hana, Doudna, Jennifer A., Kortemme, Tanja

“…The CRISPR-Cas9 system provides the ability to edit, repress, activate, or mark any gene (or DNA element) by pairing of a programmable single guide RNA (sgRNA)…”
Get full text

(3041) Proposal to conserve the name Erythroxylum suberosum against Steudelia brasiliensis (Erythroxylaceae) by Costa‐Lima, James Lucas, Oliveira Chagas, Earl Celestino

Get full text

The Physiology and Biomechanics of Skin Flaps by Lucas, James B., MD

“…Facial skin defects created by Mohs micrographic surgery are commonly reconstructed using local cutaneous flaps from surrounding skin. To provide optimal…”
Get full text

Mindful energy and information flow: A reflective account of S.E.L.F connection during COVID-19 by Lucas, James J

“…Life during the COVID-19 pandemic is uncertain, intense, and traumatic. At the same time, there is room for hope, inspiration, and meaning for social workers…”
Get full text

Adapting Group Model Building for Mental Healthcare: A Participatory Co-Design Approach by Forrester-Bowling, Tari, Lucas, James J, Brown, Andrew D, Bennetts, Stephanie, Carolin, Renae, Hayward, Josh, Scott, Debbie, Peeters, Anna, McLure, James

“…Countries around the world are experiencing both a growing need for mental health services and major gaps in the delivery of mental healthcare. The World…”
Get full text

(2826) Proposal to conserve the name Bougainvillea spectabilis against B. brasiliensis (Nyctaginaceae) by Oliveira Chagas, Earl Celestino, Costa‐Lima, James Lucas

Get full text

LGBTQ+ Loss and Grief in a Cis-Heteronormative Pandemic: A Qualitative Evidence Synthesis of the COVID-19 Literature by Lucas, James J., Bouchoucha, Stéphane L., Afrouz, Rojan, Reed, Kirk, Brennan-Olsen, Sharon L.

“…LGBTQ+ people are no stranger to loss and grief, particularly during times of pandemic such as the 1980s–90s HIV/AIDS pandemic and now, the COVID-19 pandemic…”
Get full text

Treatment patterns among patients with moderate-to-severe ulcerative colitis in the United States and Europe by Armuzzi, Alessandro, DiBonaventura, Marco daCosta, Tarallo, Miriam, Lucas, James, Bluff, Daniel, Hoskin, Benjamin, Bargo, Danielle, Cappelleri, Joseph C, Quirk, Daniel, Salese, Leonardo

“…The aim of the present study is to examine how moderate-to-severe ulcerative colitis (UC) is currently managed in real-world clinical practice across the…”
Get full text

When primary healthcare meets queerstory: community-based system dynamics influencing regional/rural LGBTQ + people's access to quality primary healthcare in Australia by Lucas, James J, Afrouz, Rojan, Brown, Andrew D, Epstein, Sarah, Ryan, Joleen, Hayward, Joshua, Brennan-Olsen, Sharon L

“…Lesbian, gay, bisexual, transgender, Queer, and people of any other minority sexuality or gender identity (LGBTQ + or "Queer") are often marginalised from…”
Get full text

Identification and Analysis of Axolotl Homologs for Proteins Implicated in Human Neurodegenerative Proteinopathies by James, Lucas M, Strickland, Zachary, Lopez, Noah, Whited, Jessica L, Maden, Malcolm, Lewis, Jada

“…Neurodegenerative proteinopathies such as Alzheimer's Disease are characterized by abnormal protein aggregation and neurodegeneration. Neuroresilience or…”
Get full text

Helium‐isotope constraints on palaeoceanographic change and sedimentation rates during precession cycles (Cenomanian Scaglia Bianca Formation, central Italy) by Lucas, James R., Batenburg, Sietske J., Hillegonds, Darren J., Mabry, Jennifer C., Jenkyns, Hugh C., Ballentine, Chris J., Robinson, Stuart A.

“…For much of the pelagic sedimentary record, time control is limited to the resolution of precession cycles (ca 20 kyr): the Milankovitch parameter that forms…”
Get full text

Comparison of different annotation tools for characterization of the complete chloroplast genome of Corylus avellana cv Tombul by Kahraman, Kadriye, Lucas, Stuart James

“…Several bioinformatics tools have been designed for assembly and annotation of chloroplast (cp) genomes, making it difficult to decide which is most useful and…”
Get full text

Co‐designing restrictive practice elimination: A systems thinking approach with mental health service users and practitioners in rural/regional Australia by Bennetts, Stephanie L., Pepin, Genevieve, Moylan, Steven, Carolin, Renae, Forrester‐Bowling, Tari, McLure, James, Brown, Andrew D., Lucas, James J.

“…Elimination of restrictive practices (physical/mechanical restraint and seclusion) from adult acute mental health care services has been demanded…”
Get full text

In Pursuit of Perfection: The Art of Facial Restoration by Lucas, James B.

Get full text

Power guidelines for process monitoring by Davis, Darwin J., Lucas, James M., Saniga, Erwin M., Saccucci, Michael S.

“…We present a process for designing monitoring procedures that includes practical power guidelines. These guidelines are based upon the average run length…”
Get full text