Search Results - "Lucas, Calixto‐Hope G."
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Frontal lobe mass in a 46‐year‐old woman
Published in Brain pathology (Zurich, Switzerland) (01-01-2024)“…The clinical significance of H3 K27M mutation in hemispheric gliomas and the prognostic value of other histologic features (growth pattern, mitotic rate, and…”
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Surgical outcomes after reoperation for recurrent skull base meningiomas
Published in Journal of neurosurgery (01-03-2019)“…Skull base meningiomas are surgically challenging tumors due to the intricate skull base anatomy and the proximity of cranial nerves and critical cerebral…”
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Meningioma metastases: incidence and proposed screening paradigm
Published in Journal of neurosurgery (01-05-2020)“…Extracranial meningioma metastases are uncommon, occurring in less than 1% of patients diagnosed with meningioma. Due to the rarity of meningioma metastases,…”
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Tuberculum sellae meningiomas: grading scale to assess surgical outcomes using the transcranial versus transsphenoidal approach
Published in Neurosurgical focus (01-04-2018)“…OBJECTIVE Tuberculum sellae meningiomas (TSMs) are surgically challenging tumors that can severely impair vision. Debate exists regarding whether the…”
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Myxoid glioneuronal tumor, PDGFRA p.K385‐mutant: clinical, radiologic, and histopathologic features
Published in Brain pathology (Zurich, Switzerland) (01-05-2020)“…“Myxoid glioneuronal tumor, PDGFRA p.K385‐mutant” is a recently described tumor entity of the central nervous system with a predilection for origin in the…”
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Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance
Published in Nature communications (12-01-2024)“…Schwann cell tumors are the most common cancers of the peripheral nervous system and can arise in patients with neurofibromatosis type-1 (NF-1) or…”
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Management and Molecular Characterization of Intraventricular Glioblastoma: A Single-Institution Case Series
Published in International journal of molecular sciences (01-09-2023)“…While the central nervous system (CNS) tumor classification has increasingly incorporated molecular parameters, there is a paucity of literature reporting…”
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Primary Central Nervous System Lymphomas: A Diagnostic Overview of Key Histomorphologic, Immunophenotypic, and Genetic Features
Published in Diagnostics (Basel) (11-12-2020)“…Primary central nervous system lymphoma (PCNSL) is a rare form of extranodal non-Hodgkin lymphoma that primarily arises in the brain, spinal cord,…”
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Targeted Next-Generation Sequencing Identifies Molecular and Genetic Events in Dedifferentiated Chondrosarcoma
Published in Archives of pathology & laboratory medicine (1976) (01-08-2021)“…Context.--Dedifferentiated chondrosarcoma is a rare adult bone tumor with a dismal prognosis and is composed of a conventional chondrosarcoma juxtaposed to…”
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Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities
Published in Nature genetics (01-05-2022)“…Meningiomas are the most common primary intracranial tumors. There are no effective medical therapies for meningioma patients, and new treatments have been…”
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A review of recently described genetic alterations in central nervous system tumors
Published in Human pathology (01-02-2020)“…Advances in molecular profiling of central nervous system tumors have enabled the development of classification schemes with improved diagnostic and prognostic…”
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Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features
Published in Neuro-oncology (Charlottesville, Va.) (14-03-2023)“…Abstract Background Meningiomas, the most common primary intracranial tumors, can be separated into 3 DNA methylation groups with distinct biological drivers,…”
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ALK-positive histiocytosis with KIF5B-ALK fusion in the central nervous system
Published in Acta neuropathologica (01-08-2019)Get full text
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Educational Case: Mitochondrial Myopathy
Published in Academic pathology (2019)“…The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for…”
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Loss of p16 expression is a sensitive marker of CDKN2A homozygous deletion in malignant meningiomas
Published in Acta neuropathologica (01-04-2023)Get full text
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Sarcomatous Meningioma: Diagnostic Pitfalls and the Utility of Molecular Testing
Published in Journal of neuropathology and experimental neurology (01-08-2021)“…Abstract Anaplastic meningiomas can have a sarcomatous appearance on histology but true sarcomatous (metaplastic) differentiation is rare. These tumors follow…”
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Clinical, histological, and molecular features of gliomas in adults with neurofibromatosis type 1
Published in Neuro-oncology (Charlottesville, Va.) (03-08-2023)“…Abstract Background People with NF1 have an increased prevalence of central nervous system malignancy. However, little is known about the clinical course or…”
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Radiotherapy for meningiomas
Published in Journal of neuro-oncology (01-11-2022)“…Meningiomas are the most common primary central nervous system neoplasm. Despite promising recent progress in elucidating the genomic landscape and underlying…”
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Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution
Published in Nature genetics (01-06-2024)“…Intratumor heterogeneity underlies cancer evolution and treatment resistance, but targetable mechanisms driving intratumor heterogeneity are poorly understood…”
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