Search Results - "Lucarini, Elena"

Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients by D'Amato, Alfonsina, Di Cesare Mannelli, Lorenzo, Lucarini, Elena, Man, Angela L, Le Gall, Gwenaelle, Branca, Jacopo J V, Ghelardini, Carla, Amedei, Amedeo, Bertelli, Eugenio, Regoli, Mari, Pacini, Alessandra, Luciani, Giulia, Gallina, Pasquale, Altera, Annalisa, Narbad, Arjan, Gulisano, Massimo, Hoyles, Lesley, Vauzour, David, Nicoletti, Claudio

“…The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a…”
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Effect of glucoraphanin and sulforaphane against chemotherapy‐induced neuropathic pain: Kv7 potassium channels modulation by H2S release in vivo by Lucarini, Elena, Micheli, Laura, Trallori, Elena, Citi, Valentina, Martelli, Alma, Testai, Lara, De Nicola, Gina Rosalinda, Iori, Renato, Calderone, Vincenzo, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo

“…The beneficial effects of isothiocyanate‐based compounds, as well as their safety, have been shown in neuropathological disorders, such as neuropathic pain…”
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New insights in the mechanisms of opioid analgesia and tolerance: Ultramicronized palmitoylethanolamide down-modulates vascular endothelial growth factor-A in the nervous system by Micheli, Laura, Nobili, Stefania, Lucarini, Elena, Toti, Alessandra, Margiotta, Francesco, Ciampi, Clara, Venturi, Daniel, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla

“…Growing evidence suggests that opioid analgesics modulate angiogenesis during pathophysiological processes. Vascular endothelial growth factor-A (VEGF-A) was…”
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Neuronal alarmin IL-1α evokes astrocyte-mediated protective signals: Effectiveness in chemotherapy-induced neuropathic pain by Di Cesare Mannelli, Lorenzo, Micheli, Laura, Cervetto, Chiara, Toti, Alessandra, Lucarini, Elena, Parisio, Carmen, Marcoli, Manuela, Ghelardini, Carla

“…The distinction between glial painful and protective pathways is unclear and the possibility to finely modulate the system is lacking. Focusing on painful…”
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Pain Relieving and Neuroprotective Effects of Non-opioid Compound, DDD-028, in the Rat Model of Paclitaxel-Induced Neuropathy by Micheli, Laura, Rajagopalan, Raghavan, Lucarini, Elena, Toti, Alessandra, Parisio, Carmen, Carrino, Donatello, Pacini, Alessandra, Ghelardini, Carla, Rajagopalan, Parthasarathi, Di Cesare Mannelli, Lorenzo

“…Chemotherapy-induced neuropathy (CIN) is a major dose-limiting side effect of anticancer therapy that can compel therapy discontinuation. Inadequate analgesic…”
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Investigating epithelial-neuronal signaling contribution in visceral pain through colon organoid-dorsal root ganglion neuron co-cultures by Margiotta, Francesco, Di Cesare Mannelli, Lorenzo, Morabito, Antonino, Ghelardini, Carla, Lucarini, Elena

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Naturally occurring glucosinolates and isothiocyanates as a weapon against chronic pain: potentials and limits by Lucarini, Elena, Micheli, Laura, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla

“…Investigation into glucosinolates (GLs) therapeutic effects boasts a long history, which began with the evidence that their hydrolysis-derived isothiocyanates…”
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Anti-Hyperalgesic Efficacy of Acetyl L-Carnitine (ALCAR) Against Visceral Pain Induced by Colitis: Involvement of Glia in the Enteric and Central Nervous System by Lucarini, Elena, Micheli, Laura, Toti, Alessandra, Ciampi, Clara, Margiotta, Francesco, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla

“…The management of abdominal pain in patients affected by inflammatory bowel diseases (IBDs) still represents a problem because of the lack of effective…”
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Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A3 Receptor Subtype by Coppi, Elisabetta, Cherchi, Federica, Lucarini, Elena, Ghelardini, Carla, Pedata, Felicita, Jacobson, Kenneth A., Di Cesare Mannelli, Lorenzo, Pugliese, Anna Maria, Salvemini, Daniela

“…Agonists of the Gi protein-coupled A3 adenosine receptor (A3AR) have shown important pain-relieving properties in preclinical settings of several pain models…”
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VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody by Micheli, Laura, Parisio, Carmen, Lucarini, Elena, Vona, Alessia, Toti, Alessandra, Pacini, Alessandra, Mello, Tommaso, Boccella, Serena, Ricciardi, Flavia, Maione, Sabatino, Graziani, Grazia, Lacal, Pedro Miguel, Failli, Paola, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo

“…Neuropathic pain is a clinically relevant adverse effect of several anticancer drugs that markedly impairs patients' quality of life and frequently leads to…”
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Pomegranate Mesocarp against Colitis-Induced Visceral Pain in Rats: Effects of a Decoction and Its Fractions by Parisio, Carmen, Lucarini, Elena, Micheli, Laura, Toti, Alessandra, Khatib, Mohamad, Mulinacci, Nadia, Calosi, Laura, Bani, Daniele, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla

“…The management of chronic visceral pain related to Inflammatory Bowel Diseases or Irritable Bowel Syndrome is still a clinical problem and new therapeutic…”
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Therapeutic Potential of Highly Selective A3 Adenosine Receptor Ligands in the Central and Peripheral Nervous System by Coppi, Elisabetta, Cherchi, Federica, Venturini, Martina, Lucarini, Elena, Corradetti, Renato, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Pedata, Felicita, Pugliese, Anna

“…Ligands of the Gi protein-coupled adenosine A3 receptor (A3R) are receiving increasing interest as attractive therapeutic tools for the treatment of a number…”
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Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice by Micheli, Laura, Vasarri, Marzia, Barletta, Emanuela, Lucarini, Elena, Ghelardini, Carla, Degl'Innocenti, Donatella, Di Cesare Mannelli, Lorenzo

“…(L.) Delile is traditionally used for its beneficial properties. Recently, promising antioxidant and anti-inflammatory biological properties emerged through…”
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Eruca sativa Meal against Diabetic Neuropathic Pain: An H2S-Mediated Effect of Glucoerucin by Lucarini, Elena, Pagnotta, Eleonora, Micheli, Laura, Parisio, Carmen, Testai, Lara, Martelli, Alma, Calderone, Vincenzo, Matteo, Roberto, Lazzeri, Luca, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla

“…The management of pain in patients affected by diabetic neuropathy still represents an unmet therapeutic need. Recent data highlighted the pain-relieving…”
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Healthy Properties of a New Formulation of Pomegranate-Peel Extract in Mice Suffering from Experimental Autoimmune Encephalomyelitis by Vallarino, Giulia, Salis, Annalisa, Lucarini, Elena, Turrini, Federica, Olivero, Guendalina, Roggeri, Alessandra, Damonte, Gianluca, Boggia, Raffaella, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Pittaluga, Anna

“…A new formulation of a pomegranate-peel extract (PEm) obtained by PUAE (Pulsed Ultrasound-Assisted Extraction) and titrated in both ellagic acid (EA) and…”
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New Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies by Crocetti, Letizia, Guerrini, Gabriella, Giovannoni, Maria Paola, Melani, Fabrizio, Lamanna, Silvia, Di Cesare Mannelli, Lorenzo, Lucarini, Elena, Ghelardini, Carla, Wang, Junjie, Dahl, Gerhard

“…The channel protein Panx-1 is involved in some pathologies, such as epilepsy, ischemic stroke, cancer and Parkinson's disease, as well as in neuropathic pain…”
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Correction: VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody by Micheli, Laura, Parisio, Carmen, Lucarini, Elena, Vona, Alessia, Toti, Alessandra, Pacini, Alessandra, Mello, Tommaso, Boccella, Serena, Ricciardi, Flavia, Maione, Sabatino, Graziani, Grazia, Lacal, Pedro Miguel, Failli, Paola, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo

“…The correction does not alter the scientific outcome since the result about the colocalization analysis of VEGF-A and GFAP in control and oxaliplatin-treated…”
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Ultramicronized N -palmitoylethanolamine Contributes to Morphine Efficacy Against Neuropathic Pain: Implication of Mast Cells and Glia by Micheli, Laura, Lucarini, Elena, Nobili, Stefania, Bartolucci, Gianluca, Pallecchi, Marco, Toti, Alessandra, Ferrara, Valentina, Ciampi, Clara, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo

“…Background: In the current management of neuropathic pain, in addition to antidepressants and anticonvulsants, the use of opioids is wide, despite their…”
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Restorative and pain-relieving effects of fibroin in preclinical models of tendinopathy by Micheli, Laura, Parisio, Carmen, Lucarini, Elena, Carrino, Donatello, Ciampi, Clara, Toti, Alessandra, Ferrara, Valentina, Pacini, Alessandra, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo

“…The term tendinopathy indicates a wide spectrum of conditions characterized by alterations in tendon tissue homeostatic response and damage to the…”
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Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold by Reale, Annalisa, Brogi, Simone, Chelini, Alessia, Paolino, Marco, Di Capua, Angela, Giuliani, Germano, Cappelli, Andrea, Giorgi, Gianluca, Chemi, Giulia, Grillo, Alessandro, Valoti, Massimo, Sautebin, Lidia, Rossi, Antonietta, Pace, Simona, La Motta, Concettina, Di Cesare Mannelli, Lorenzo, Lucarini, Elena, Ghelardini, Carla, Anzini, Maurizio

“…[Display omitted] •Design, synthesis and biological evaluation of novel COX-2 selective inhibitors.•COX-2 inhibitors are efficacious as analgesic agents in…”
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