Search Results - "Luca, Chiara De"
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The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography
Published in Molecules (Basel, Switzerland) (20-10-2018)“…Until less than 10 years ago, chiral separations were carried out with columns packed with 5 or 3 μ m fully porous particles (FPPs). Times to resolve…”
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2
Biosafety of Prions
Published in Progress in molecular biology and translational science (2017)“…Prions are the infectious agents that cause devastating and untreatable disorders known as Transmissible Spongiform Encephalopathies (TSEs). The pathologic…”
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3
Clinical and biochemical effects of coenzyme Q10 , vitamin E, and selenium supplementation to psoriasis patients
Published in Nutrition (Burbank, Los Angeles County, Calif.) (01-03-2009)“…Abstract Objective The aim of the present study was to evaluate clinical effects of supplementation with antioxidants to patients with severe erythrodermic…”
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Anti-Bacterial and Anti-Inflammatory Effects of Toothpaste with Swiss Medicinal Herbs towards Patients Suffering from Gingivitis and Initial Stage of Periodontitis: from Clinical Efficacy to Mechanisms
Published in Dentistry journal (15-01-2020)“…To distinguish clinical effects and mechanisms of sodium monofluorophosphate plus xylitol and herbal extracts of Swiss medicinal plants (Chamomilla recutita,…”
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Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State
Published in International journal of molecular sciences (18-01-2019)“…Beta-2 microglobulin (β2m) is a protein responsible for a pathologic condition, known as dialysis-related amyloidosis (DRA), caused by its aggregation and…”
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Anti-Inflammatory Effects of Concentrated Ethanol Extracts of Edelweiss (Leontopodium alpinum Cass.) Callus Cultures towards Human Keratinocytes and Endothelial Cells
Published in Mediators of Inflammation (01-01-2012)“…Edelweiss (Leontopodium alpinum Cass.) is traditionally employed in folk medicine as an anti-inflammatory remedy. In nature, the plant is sparsely available…”
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Novel insights into the dependence of adsorption-desorption kinetics on particle geometry in chiral chromatography
Published in Analytical and bioanalytical chemistry (01-03-2024)“…The existence of slow adsorption-desorption kinetics in chiral liquid chromatography is common knowledge. This may significantly contribute to worsening the…”
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PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice
Published in eLife (14-04-2021)“…Fatal Familial Insomnia (FFI) is a genetic prion disease caused by the D178N mutation in the prion protein gene (PRNP) in coupling phase with methionine at…”
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Retrotransposon LINE-1 bodies in the cytoplasm of piRNA-deficient mouse spermatocytes: Ribonucleoproteins overcoming the integrated stress response
Published in PLoS genetics (12-06-2023)“…Transposable elements (TE) are mobile DNA sequences whose excessive proliferation endangers the host. Although animals have evolved robust TE-targeting…”
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From batch to continuous chromatographic purification of a therapeutic peptide through multicolumn countercurrent solvent gradient purification
Published in Journal of Chromatography A (16-08-2020)“…highlights•A MCSGP process has been developed for the purification of glucagon from a crude synthetic mixture.•The procedure on how to develop the MCSGP…”
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Differential modulation of stress-inflammation responses by plant polyphenols in cultured normal human keratinocytes and immortalized HaCaT cells
Published in Journal of dermatological science (01-08-2011)“…Abstract Background Environmental and endogenous stresses to skin are considered causative reasons for skin cancers, premature ageing, and chronic…”
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12
Downstream Processing of Therapeutic Peptides by Means of Preparative Liquid Chromatography
Published in Molecules (Basel, Switzerland) (03-08-2021)“…The market of biomolecules with therapeutic scopes, including peptides, is continuously expanding. The interest towards this class of pharmaceuticals is…”
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13
Thalamo-cortical spiking model of incremental learning combining perception, context and NREM-sleep
Published in PLoS computational biology (28-06-2021)“…The brain exhibits capabilities of fast incremental learning from few noisy examples, as well as the ability to associate similar memories in…”
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Fast Simulations of Highly-Connected Spiking Cortical Models Using GPUs
Published in Frontiers in computational neuroscience (17-02-2021)“…Over the past decade there has been a growing interest in the development of parallel hardware systems for simulating large-scale networks of spiking neurons…”
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Challenges in molecular diagnosis of X-linked Intellectual disability
Published in British medical bulletin (15-05-2020)“…Intellectual disability (ID) affects 1-3% of the Western population and is heterogeneous in origin. Mutations in X-linked genes represent 5-10% of ID in males…”
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Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli
Published in Mediators of Inflammation (01-01-2010)“…Skin surface lipid (SSL) film is a mixture of sebum and keratinocyte membrane lipids, protecting skin from environment. Its composition is unique for the high…”
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Oligonucleotides: Current Trends and Innovative Applications in the Synthesis, Characterization, and Purification
Published in Biotechnology journal (01-08-2020)“…Oligonucleotides (ONs) are gaining increasing importance as a promising novel class of biopharmaceuticals. Thanks to their fundamental role in gene regulation,…”
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Label-free imaging and biochemical characterization of bovine sperm cells
Published in Biosensors (Basel) (01-04-2015)“…A full label-free morphological and biochemical characterization is desirable to select spermatozoa during preparation for artificial insemination. In order to…”
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Raman Microscopy: Progress in Research on Cancer Cell Sensing
Published in Sensors (Basel, Switzerland) (27-09-2020)“…In the last decade, Raman Spectroscopy (RS) was demonstrated to be a label-free, non-invasive and non-destructive optical spectroscopy allowing the improvement…”
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Recent Achievements and Future Challenges in Supercritical Fluid Chromatography for the Enantioselective Separation of Chiral Pharmaceuticals
Published in Chromatographia (01-01-2019)“…During the last years, supercritical fluid chromatography (SFC) has attracted a continuously growing number of users. Thanks to the introduction of…”
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