Search Results - "Luca, Bogdan A"

Atlas of clinically distinct cell states and ecosystems across human solid tumors by Luca, Bogdan A., Steen, Chloé B., Matusiak, Magdalena, Azizi, Armon, Varma, Sushama, Zhu, Chunfang, Przybyl, Joanna, Espín-Pérez, Almudena, Diehn, Maximilian, Alizadeh, Ash A., van de Rijn, Matt, Gentles, Andrew J., Newman, Aaron M.

“…Determining how cells vary with their local signaling environment and organize into distinct cellular communities is critical for understanding processes as…”
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The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma by Steen, Chloé B., Luca, Bogdan A., Esfahani, Mohammad S., Azizi, Armon, Sworder, Brian J., Nabet, Barzin Y., Kurtz, David M., Liu, Chih Long, Khameneh, Farnaz, Advani, Ranjana H., Natkunam, Yasodha, Myklebust, June H., Diehn, Maximilian, Gentles, Andrew J., Newman, Aaron M., Alizadeh, Ash A.

“…Biological heterogeneity in diffuse large B cell lymphoma (DLBCL) is partly driven by cell-of-origin subtypes and associated genomic lesions, but also by…”
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Determining cell type abundance and expression from bulk tissues with digital cytometry by Newman, Aaron M., Steen, Chloé B., Liu, Chih Long, Gentles, Andrew J., Chaudhuri, Aadel A., Scherer, Florian, Khodadoust, Michael S., Esfahani, Mohammad S., Luca, Bogdan A., Steiner, David, Diehn, Maximilian, Alizadeh, Ash A.

“…Single-cell RNA-sequencing has emerged as a powerful technique for characterizing cellular heterogeneity, but it is currently impractical on large sample…”
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T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma by Lozano, Alexander X., Chaudhuri, Aadel A., Nene, Aishwarya, Bacchiocchi, Antonietta, Earland, Noah, Vesely, Matthew D., Usmani, Abul, Turner, Brandon E., Steen, Chloé B., Luca, Bogdan A., Badri, Ti, Gulati, Gunsagar S., Vahid, Milad R., Khameneh, Farnaz, Harris, Peter K., Chen, David Y., Dhodapkar, Kavita, Sznol, Mario, Halaban, Ruth, Newman, Aaron M.

“…Severe immune-related adverse events (irAEs) occur in up to 60% of patients with melanoma treated with immune checkpoint inhibitors (ICIs). However, it is…”
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AML/T cell interactomics uncover correlates of patient outcomes and the key role of ICAM1 in T cell killing of AML by Sayitoglu, Ece Canan, Luca, Bogdan A., Boss, Allison Paige, Thomas, Benjamin Craig, Freeborn, Robert Arthur, Uyeda, Molly Javier, Chen, Pauline Ping, Nakauchi, Yusuke, Waichler, Colin, Lacayo, Norman, Bacchetta, Rosa, Majeti, Ravindra, Gentles, Andrew J., Cepika, Alma-Martina, Roncarolo, Maria Grazia

“…T cells are important for the control of acute myeloid leukemia (AML), a common and often deadly malignancy. We observed that some AML patient samples are…”
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Profiling Cellular Ecosystems at Single-Cell Resolution and at Scale with EcoTyper by Steen, Chloé B, Luca, Bogdan A, Alizadeh, Ash A, Gentles, Andrew J, Newman, Aaron M

“…Tissues are composed of diverse cell types and cellular states that organize into distinct ecosystems with specialized functions. EcoTyper is a collection of…”
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Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy by Subramanian, Ajay, Nemat-Gorgani, Neda, Ellis-Caleo, Timothy J, van IJzendoorn, David G P, Sears, Timothy J, Somani, Anish, Luca, Bogdan A, Zhou, Maggie Y, Bradic, Martina, Torres, Ileana A, Oladipo, Eniola, New, Christin, Kenney, Deborah E, Avedian, Raffi S, Steffner, Robert J, Binkley, Michael S, Mohler, David G, Tap, William D, D'Angelo, Sandra P, van de Rijn, Matt, Ganjoo, Kristen N, Bui, Nam Q, Charville, Gregory W, Newman, Aaron M, Moding, Everett J

“…Characterization of the diverse malignant and stromal cell states that make up soft tissue sarcomas and their correlation with patient outcomes has proven…”
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Single Cell Analysis of Adult Human Hematopoietic Stem and Progenitor Cells Identifies a Novel Lymphoid Primed Multipotent Progenitor That Expands in Relapsed Acute Myeloid Leukemia by Ediriwickrema, Asiri, Luca, Bogdan A., Newman, Aaron M, Gentles, Andrew J, Majeti, Ravindra

“…Background: Hematopoietic stem and progenitor cells (HSPCs) are capable of generating all human blood cells. Although these cells have been extensively…”
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Abstract 3443: Atlas of clinically-distinct cell states and cellular ecosystems across human solid tumors by Luca, Bogdan A., Steen, Chloé B., Azizi, Armon, Matusiak, Magdalena, Przybyl, Joanna, Neishaboori, Nastaran, Pérez, Almudena Espín, Diehn, Maximilian, Alizadeh, Ash A., van de Rijn, Matt, Gentles, Andrew J., Newman, Aaron M.

“…Abstract Tumors are complex ecosystems consisting of malignant, immune, and stromal elements whose dynamic interactions drive patient survival and response to…”
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An Atlas of Clinically-Distinct Tumor Cellular Ecosystems in Diffuse Large B Cell Lymphoma by Steen, Chloe B., Luca, Bogdan A., Esfahani, Mohammad Shahrokh, Nabet, Barzin Y., Sworder, Brian, Farshidfar, Farshad, Shamardani, Kiarash, Kurtz, David M., Liu, Chih Long, Advani, Ranjana H, Natkunam, Yasodha, Myklebust, June Helen, Diehn, Maximilian, Gentles, Andrew, Newman, Aaron M, Alizadeh, Ash A.

“…Background: Diffuse large B cell lymphoma (DLBCL) exhibits significant clinical and biological heterogeneity, in part due to cell-of-origin subtypes, somatic…”
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Abstract 6560: Cell-free RNA analysis for non-invasive cancer detection and characterization by Nesselbush, Monica C., Luca, Bogdan A., Jeon, Young-Jun, Jabara, Isabel, Meador, Catherine B., Binkley, Michael S., Xu, Nova, Hui, Angela B., Garofalo, Andrea, Shi, William Y., Liu, Kevin J., Sugio, Takeshi, Kastelowitz, Noah, Hamilton, Emily G., Bonilla, Rene F., Wang, Yi Peng, Jiang, Alice, Lau, Brianna, Eichholz, Jordan, Banwait, Mandeep, Schroers-Martin, Joseph, Boegeholz, Jan, King, Daniel A., Esfahani, Mohammad S., Raclin, Tyler, Tibshirani, Robert, Srinivas, Sandy, Nair, Viswam S., Isbell, James M., Li, Bob T., Piotrowska, Zofia, Sequist, Lecia V., Hata, Aaron N., Neal, Joel W., Wakelee, Heather A., Gentles, Andrew J., Alizadeh, Ash A., Diehn, Maximilian

“…Abstract Blood-based liquid biopsies enable non-invasive characterization of cancers. Cell-free RNA (cfRNA) analysis could potentially complement circulating…”
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Abstract 5960: Identification and validation of sarcoma cellular ecosystems associated with prognosis and predictive of immunotherapy response by Subramanian, Ajay, Nemat-Gorgani, Neda, Ellis-Caleo, Timothy J., van IJzendoorn, David G.P., Sears, Timothy J., Somani, Anish, Luca, Bogdan A., Zhou, Maggie Y., Bradic, Martina, Torres, Ileana A., Oladipo, Eniola, New, Christin, Kenney, Deborah E., Avedian, Raffi S., Steffner, Robert J., Binkley, Michael S., Mohler, David G., Tap, William D., D’Angelo, Sandra P., van de Rijn, Matt, Ganjoo, Kristen N., Bui, Nam Q., Charville, Gregory W., Newman, Aaron M., Moding, Everett J.

“…Abstract The tumor microenvironment contributes to tumorigenesis, disease progression, and response to therapy in soft tissue sarcomas (STSs). However,…”
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