Search Results - "Luc J.W. van der Laan"

A Chemically Defined Hydrogel for Human Liver Organoid Culture by Ye, Shicheng, Boeter, Jochem W.B., Mihajlovic, Marko, Steenbeek, Frank G., Wolferen, Monique E., Oosterhoff, Loes A., Marsee, Ary, Caiazzo, Massimiliano, Laan, Luc J.W., Penning, Louis C., Vermonden, Tina, Spee, Bart, Schneeberger, Kerstin

“…End‐stage liver diseases are an increasing health burden, and liver transplantations are currently the only curative treatment option. Due to a lack of donor…”
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Posttransplant Management of Recipients Undergoing Liver Transplantation for Hepatocellular Carcinoma. Working Group Report From the ILTS Transplant Oncology Consensus Conference by Berenguer, Marina, Burra, Patrizia, Ghobrial, Mark, Hibi, Taizo, Metselaar, Herold, Sapisochin, Gonzalo, Bhoori, Sherrie, Kwan Man, Nancy, Mas, Valeria, Ohira, Masahiro, Sangro, Bruno, van der Laan, Luc J.W.

“…Although liver transplantation (LT) is the best treatment for patients with localized hepatocellular carcinoma (HCC), recurrence occurs in 6%–18% of patients…”
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Calcineurin Inhibitors Stimulate and Mycophenolic Acid Inhibits Replication of Hepatitis E Virus by Wang, Yijin, Zhou, Xinying, Debing, Yannick, Chen, Kan, Van Der Laan, Luc J.W, Neyts, Johan, Janssen, Harry L.A, Metselaar, Herold J, Peppelenbosch, Maikel P, Pan, Qiuwei

“…Background & Aims Many recipients of organ transplants develop chronic hepatitis, due to infection with the hepatitis E virus (HEV). Although chronic HEV…”
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Biomarkers to assess graft quality during conventional and machine preservation in liver transplantation by Verhoeven, Cornelia J, Farid, Waqar R.R, de Jonge, Jeroen, Metselaar, Herold J, Kazemier, Geert, van der Laan, Luc J.W

“…Summary A global rising organ shortage necessitates the use of extended criteria donors (ECD) for liver transplantation (LT). However, poor preservation and…”
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Counter-regulation of rejection activity against human liver grafts by donor PD-L1 and recipient PD-1 interaction by Shi, Xiao-Lei, Mancham, Shanta, Hansen, Bettina E, de Knegt, Robert J, de Jonge, Jeroen, van der Laan, Luc J.W, Rivadeneira, Fernando, Metselaar, Herold J, Kwekkeboom, Jaap

“…Graphical abstract…”
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From organoids to organs: Bioengineering liver grafts from hepatic stem cells and matrix by Willemse, Jorke, MSc, PhD-student, Lieshout, Ruby, BSc, PhD-student, van der Laan, Luc J.W., PhD, Verstegen, Monique M.A., PhD

“…Abstract Due to the complex function and structure of the liver, resourceful solutions for treating end-stage liver disease are required. Currently, liver…”
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Distinct Antiviral Potency of Sofosbuvir against Hepatitis C and E Viruses by Wang, Wenshi, Hakim, Mohamad S, Nair, Vidya P, de Ruiter, Petra E, Huang, Fen, Sprengers, Dave, Van Der Laan, Luc J.W, Peppelenbosch, Maikel P, Surjit, Milan, Pan, Qiuwei

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Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice by Salomon, Daniel R, van der Laan, Luc J.W, Lockey, Christopher, Griffeth, Bradley C, Frasier, Francine S, Wilson, Carolyn A, Onions, David E, Hering, Bernhard J, Long, Zhifeng, Otto, Edward, Torbett, Bruce E

“…Animal donors such as pigs could provide an alternative source of organs for transplantation. However, the promise of xenotransplantation is offset by the…”
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Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver by Huch, Meritxell, Gehart, Helmuth, van Boxtel, Ruben, Hamer, Karien, Blokzijl, Francis, Verstegen, Monique M.A., Ellis, Ewa, van Wenum, Martien, Fuchs, Sabine A., de Ligt, Joep, van de Wetering, Marc, Sasaki, Nobuo, Boers, Susanne J., Kemperman, Hans, de Jonge, Jeroen, Ijzermans, Jan N.M., Nieuwenhuis, Edward E.S., Hoekstra, Ruurdtje, Strom, Stephen, Vries, Robert R.G., van der Laan, Luc J.W., Cuppen, Edwin, Clevers, Hans

“…Despite the enormous replication potential of the human liver, there are currently no culture systems available that sustain hepatocyte replication and/or…”
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Large‐Scale Production of LGR5‐Positive Bipotential Human Liver Stem Cells by Schneeberger, Kerstin, Sánchez‐Romero, Natalia, Ye, Shicheng, Steenbeek, Frank G., Oosterhoff, Loes A., Pla Palacin, Iris, Chen, Chen, Wolferen, Monique E., Tienderen, Gilles, Lieshout, Ruby, Colemonts‐Vroninks, Haaike, Schene, Imre, Hoekstra, Ruurdtje, Verstegen, Monique M.A., Laan, Luc J.W., Penning, Louis C., Fuchs, Sabine A., Clevers, Hans, De Kock, Joery, Baptista, Pedro M., Spee, Bart

“…Background and Aims The gap between patients on transplant waiting lists and available donor organs is steadily increasing. Human organoids derived from…”
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New targets for treatment against HCV infection by Pan, Qiuwei, PhD, van der Laan, Luc J.W., PhD

“…Abstract Owing to the tremendous effort from both academia and industry, drug development for hepatitis C virus (HCV) infection has been flourishing, with a…”
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Modeling rotavirus infection and antiviral therapy using primary intestinal organoids by Yin, Yuebang, Bijvelds, Marcel, Dang, Wen, Xu, Lei, van der Eijk, Annemiek A., Knipping, Karen, Tuysuz, Nesrin, Dekkers, Johanna F., Wang, Yijin, de Jonge, Jeroen, Sprengers, Dave, van der Laan, Luc J.W., Beekman, Jeffrey M., ten Berge, Derk, Metselaar, Herold J., de Jonge, Hugo, Koopmans, Marion P.G., Peppelenbosch, Maikel P., Pan, Qiuwei

“…•3D-based primary intestinal organoids support the infection of both experimental and patient-derived rotavirus strains.•Rotavirus infection provokes the…”
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Hepatobiliary tumor organoids for personalized medicine: a multicenter view on establishment, limitations, and future directions by van Tienderen, Gilles S., Li, Ling, Broutier, Laura, Saito, Yoshimasa, Inacio, Patricia, Huch, Meritxell, Selaru, Florin M., van der Laan, Luc J.W., Verstegen, Monique M.A.

“…Reliable establishment of tumor organoids is paramount to advance applications of organoid technology for personalized medicine. Here, we share our…”
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RIG‐I is a key antiviral interferon‐stimulated gene against hepatitis E virus regardless of interferon production by Xu, Lei, Wang, Wenshi, Li, Yunlong, Zhou, Xinying, Yin, Yuebang, Wang, Yijin, de Man, Robert A., van der Laan, Luc J.W., Huang, Fen, Kamar, Nassim, Peppelenbosch, Maikel P., Pan, Qiuwei

“…Interferons (IFNs) are broad antiviral cytokines that exert their function by inducing the transcription of hundreds of IFN‐stimulated genes (ISGs). However,…”
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Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids by Krüger, Melanie, Oosterhoff, Loes A., van Wolferen, Monique E., Schiele, Simon A., Walther, Andreas, Geijsen, Niels, De Laporte, Laura, van der Laan, Luc J. W., Kock, Linda M., Spee, Bart

“…To replicate functional liver tissue in vitro for drug testing or transplantation, 3D tissue engineering requires representative cell models as well as…”
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Human branching cholangiocyte organoids recapitulate functional bile duct formation by Roos, Floris J.M., van Tienderen, Gilles S., Wu, Haoyu, Bordeu, Ignacio, Vinke, Dina, Albarinos, Laura Muñoz, Monfils, Kathryn, Niesten, Sabrah, Smits, Ron, Willemse, Jorke, Rosmark, Oskar, Westergren-Thorsson, Gunilla, Kunz, Daniel J., de Wit, Maurice, French, Pim J., Vallier, Ludovic, IJzermans, Jan N.M., Bartfai, Richard, Marks, Hendrik, Simons, Ben D., van Royen, Martin E., Verstegen, Monique M.A., van der Laan, Luc J.W.

“…Human cholangiocyte organoids show great promise for regenerative therapies and in vitro modeling of bile duct development and diseases. However, the cystic…”
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Dissecting the effects and mechanism-of-action of statin use on fatty liver disease: a multidimensional study by Ayada, Ibrahim, van Kleef, Laurens, Zhang, Huai, Li, Pengfei, Liu, Kuan, Wang, Ling, Lavrijsen, Marla, Ghanbari, Mohsen, Van Der Laan, Luc J.W., Peppelenbosch, Maikel, Zheng, Ming-Hua, De Knegt, Robert, Pan, Qiuwei

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Scaffolds obtained from decellularized human extrahepatic bile ducts support organoids to establish functional biliary tissue in a dish by Willemse, Jorke, Roos, Floris J. M., Voogt, Iris J., Schurink, Ivo J., Bijvelds, Marcel, Jonge, Hugo R., Laan, Luc J. W., Jonge, Jeroen, Verstegen, Monique M. A.

“…Biliary disorders can lead to life‐threatening disease and are also a challenging complication of liver transplantation. As there are limited treatment…”
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Decellularization of Whole Human Liver Grafts Using Controlled Perfusion for Transplantable Organ Bioscaffolds by Verstegen, Monique M A, Willemse, Jorke, van den Hoek, Sjoerd, Kremers, Gert-Jan, Luider, Theo M, van Huizen, Nick A, Willemssen, Francois E J A, Metselaar, Herold J, IJzermans, Jan N M, van der Laan, Luc J W, de Jonge, Jeroen

“…Liver transplantation is the only effective treatment for end-stage liver disease, but absolute donor shortage remains a limiting factor. Recent advances in…”
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Hepatocyte‐derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation by Farid, Waqar R. R., Pan, Qiuwei, van der Meer, Adriaan J. P., de Ruiter, Petra E., Ramakrishnaiah, Vedashree, de Jonge, Jeroen, Kwekkeboom, Jaap, Janssen, Harry L. A., Metselaar, Herold J., Tilanus, Hugo W., Kazemier, Geert, van der Laan, Luc J.W.

“…Recent animal and human studies have highlighted the potential of hepatocyte‐derived microRNAs (HDmiRs) in serum as early, stable, sensitive, and specific…”
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