Search Results - "Lubinski, John M."

The Herpes Simplex Virus 1 IgG Fc Receptor Blocks Antibody-Mediated Complement Activation and Antibody-Dependent Cellular Cytotoxicity In Vivo by LUBINSKI, John M, LAZEAR, Helen M, AWASTHI, Sita, FUSHAN WANG, FRIEDMAN, Harvey M

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Novel Adjuvant S-540956 Targets Lymph Nodes and Reduces Genital Recurrences and Vaginal Shedding of HSV-2 DNA When Administered with HSV-2 Glycoprotein D as a Therapeutic Vaccine in Guinea Pigs by Awasthi, Sita, Onishi, Motoyasu, Lubinski, John M, Fowler, Bernard T, Naughton, Alexis M, Hook, Lauren M, Egan, Kevin P, Hagiwara, Masaki, Shirai, Seiki, Sakai, Akiho, Nakagawa, Takayuki, Goto, Kumiko, Yoshida, Osamu, Stephens, Alisa J, Choi, Grace, Cohen, Gary H, Katayama, Kazufumi, Friedman, Harvey M

“…Herpes simplex virus type 2 (HSV-2) is a leading cause of genital ulcer disease and a major risk factor for acquisition and transmission of HIV. Frequent…”
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Immunization with a Vaccine Combining Herpes Simplex Virus 2 (HSV-2) Glycoprotein C (gC) and gD Subunits Improves the Protection of Dorsal Root Ganglia in Mice and Reduces the Frequency of Recurrent Vaginal Shedding of HSV-2 DNA in Guinea Pigs Compared to Immunization with gD Alone by Awasthi, Sita, Lubinski, John M, Shaw, Carolyn E, Barrett, Shana M, Cai, Michael, Wang, Fushan, Betts, Michael, Kingsley, Susan, DiStefano, Daniel J, Balliet, John W, Flynn, Jessica A, Casimiro, Danilo R, Bryan, Janine T, Friedman, Harvey M

“…Attempts to develop a vaccine to prevent genital herpes simplex virus 2 (HSV-2) disease have been only marginally successful, suggesting that novel strategies…”
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Protection Provided by a Herpes Simplex Virus 2 (HSV-2) Glycoprotein C and D Subunit Antigen Vaccine against Genital HSV-2 Infection in HSV-1-Seropositive Guinea Pigs by Awasthi, Sita, Balliet, John W, Flynn, Jessica A, Lubinski, John M, Shaw, Carolyn E, DiStefano, Daniel J, Cai, Michael, Brown, Martha, Smith, Judith F, Kowalski, Rose, Swoyer, Ryan, Galli, Jennifer, Copeland, Victoria, Rios, Sandra, Davidson, Robert C, Salnikova, Maya, Kingsley, Susan, Bryan, Janine, Casimiro, Danilo R, Friedman, Harvey M

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Live Attenuated Herpes Simplex Virus 2 Glycoprotein E Deletion Mutant as a Vaccine Candidate Defective in Neuronal Spread by Awasthi, Sita, Zumbrun, Elizabeth E, Si, Huaxin, Wang, Fushan, Shaw, Carolyn E, Cai, Michael, Lubinski, John M, Barrett, Shana M, Balliet, John W, Flynn, Jessica A, Casimiro, Danilo R, Bryan, Janine T, Friedman, Harvey M

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A Replication-Competent, Neuronal Spread-Defective, Live Attenuated Herpes Simplex Virus Type 1 Vaccine by BRITTLE, Elizabeth E, FUSHAN WANG, LUBINSKI, John M, BUNTE, Ralph M, FRIEDMAN, Harvey M

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Herpes Simplex Virus Type 1 and 2 Glycoprotein C Prevents Complement-Mediated Neutralization Induced by Natural Immunoglobulin M Antibody by HOOK, Lauren M, LUBINSKI, John M, MING JIANG, PANGBURN, Michael K, FRIEDMAN, Harvey M

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Herpes Simplex Virus Type 1 Evades the Effects of Antibody and Complement In Vivo by Lubinski, John M, Jiang, Ming, Hook, Lauren, Chang, Yueh, Sarver, Chad, Mastellos, Dimitrios, Lambris, John D, Cohen, Gary H, Eisenberg, Roselyn J, Friedman, Harvey M

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Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models by Awasthi, Sita, Knox, James J, Desmond, Angela, Alameh, Mohamad-Gabriel, Gaudette, Brian T, Lubinski, John M, Naughton, Alexis, Hook, Lauren M, Egan, Kevin P, Tam, Ying K, Pardi, Norbert, Allman, David, Luning Prak, Eline T, Cancro, Michael P, Weissman, Drew, Cohen, Gary H, Friedman, Harvey M

“…Nucleoside-modified mRNA vaccines have gained global attention because of COVID-19. We evaluated a similar vaccine approach for preventing a chronic, latent…”
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Immunization Strategies To Block the Herpes Simplex Virus Type 1 Immunoglobulin G Fc Receptor by XIAOQING LIN, LUBINSKI, John M, FRIEDMAN, Harvey M

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Immunization with HSV-1 glycoprotein C prevents immune evasion from complement and enhances the efficacy of an HSV-1 glycoprotein D subunit vaccine by Awasthi, Sita, Lubinski, John M, Friedman, Harvey M

“…Abstract Herpes simplex virus type 1 (HSV-1) glycoprotein C (gC-1) binds complement component C3b and inhibits complement-mediated immunity. HSV-1 glycoprotein…”
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Blocking Immune Evasion as a Novel Approach for Prevention and Treatment of Herpes Simplex Virus Infection by Judson, Kara A, Lubinski, John M, Jiang, Ming, Chang, Yueh, Eisenberg, Roselyn J, Cohen, Gary H, Friedman, Harvey M

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Herpes simplex virus type 1 infection increases the carbohydrate binding activity and the secretion of cellular galectin-3 by King, Ryan D, Lubinski, John M, Friedman, Harvey M

“…Galectin-3 binds β-galactoside-containing sugars and is a chemoattractant for monocytes, macrophages, and neutrophils. Galectin-3 was identified by mass…”
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An HSV-1 gD mutant virus as an entry-impaired live virus vaccine by Awasthi, Sita, Lubinski, John M, Eisenberg, Roselyn J, Cohen, Gary H, Friedman, Harvey M

“…Summary HSV-1 glycoprotein D (gD) interacts with HVEM and nectin-1 cell receptors to initiate virus entry. We prepared an HSV-1 strain with mutations in the gD…”
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Herpes Simplex Virus Type 1 Glycoprotein gC Mediates Immune Evasion In Vivo by Lubinski, J M, Wang, L, Soulika, A M, Burger, R, Wetsel, R A, Colten, H, Cohen, G H, Eisenberg, R J, Lambris, J D, Friedman, H M

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Implications for herpes simplex virus vaccine strategies based on antibodies produced to herpes simplex virus type 1 glycoprotein gC immune evasion domains by Chang, Yueh J., Jiang, Ming, Lubinski, John M., King, Ryan D., Friedman, Harvey M.

“…Herpes simplex virus type I (HSV-1) glycoprotein gC (gC-1) is an immune evasion molecule that inhibits complement activation by binding C3b. Three assays were…”
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The gH-gL Complex of Herpes Simplex Virus (HSV) Stimulates Neutralizing Antibody and Protects Mice against HSV Type 1 Challenge by Peng, T, Ponce-de-Leon, M, Jiang, H, Dubin, G, Lubinski, J M, Eisenberg, R J, Cohen, G H

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Preventing neonatal herpes: Protection after maternal mRNA-lipid nanoparticle vaccination equals or exceeds that from prior maternal genital infection in murine models by Desmond, Angela, LaTourette, Philip C., Awasthi, Sita, Egan, Kevin P., Hook, Lauren M., Brice, Angela K., Lubinski, John M., Naughton, Alexis M., Fowler, Bernard, Beattie, Mitchell, Pardi, Norbert, Cohen, Gary H., Weissman, Drew, Friedman, Harvey M.

“…Neonates are vulnerable to poor outcomes from herpes simplex virus (HSV), but maternal infection eliciting non-sterilizing immunity prior to delivery provides…”
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