Search Results - "Lubbers, Laura"

Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress by Knowles, Juliet K., Helbig, Ingo, Metcalf, Cameron S., Lubbers, Laura S., Isom, Lori L., Demarest, Scott, Goldberg, Ethan M., George, Alfred L., Lerche, Holger, Weckhuysen, Sarah, Whittemore, Vicky, Berkovic, Samuel F., Lowenstein, Daniel H.

“…The genetic basis of many epilepsies is increasingly understood, giving rise to the possibility of precision treatments tailored to specific genetic…”
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Estradiol and ERβ agonists enhance recognition memory, and DPN, an ERβ agonist, alters brain monoamines by Jacome, Luis F., Gautreaux, Claris, Inagaki, Tomoko, Mohan, Govini, Alves, Stephen, Lubbers, Laura S., Luine, Victoria

“…► Estradiol enhances recognition memory. ► Estrogen enhancements in memory rely on estrogen receptor (ER) beta. ► DPN, an ER beta agonist, alters monoaminergic…”
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Transcriptional Architecture of the Primate Neocortex by Bernard, Amy, Lubbers, Laura S., Tanis, Keith Q., Luo, Rui, Podtelezhnikov, Alexei A., Finney, Eva M., McWhorter, Mollie M.E., Serikawa, Kyle, Lemon, Tracy, Morgan, Rebecca, Copeland, Catherine, Smith, Kimberly, Cullen, Vivian, Davis-Turak, Jeremy, Lee, Chang-Kyu, Sunkin, Susan M., Loboda, Andrey P., Levine, David M., Stone, David J., Hawrylycz, Michael J., Roberts, Christopher J., Jones, Allan R., Geschwind, Daniel H., Lein, Ed S.

“…Genome-wide transcriptional profiling was used to characterize the molecular underpinnings of neocortical organization in rhesus macaque, including cortical…”
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Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth by Khan, Tayeba, Weber, Hans, DiMuzio, Jillian, Matter, Andrea, Dogdas, Belma, Shah, Tosha, Thankappan, Anil, Disa, Jyoti, Jadhav, Vasant, Lubbers, Laura, Sepp-Lorenzino, Laura, Strapps, Walter R, Tadin-Strapps, Marija

“…Short interfering RNAs (siRNAs) are a valuable tool for gene silencing with applications in both target validation and therapeutics. Many advances have…”
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Antiepileptogenesis and disease modification: Progress, challenges, and the path forward—Report of the Preclinical Working Group of the 2018 NINDS‐sponsored antiepileptogenesis and disease modification workshop by Galanopoulou, Aristea S., Löscher, Wolfgang, Lubbers, Laura, O’Brien, Terence J., Staley, Kevin, Vezzani, Annamaria, D’Ambrosio, Raimondo, White, H. Steve, Sontheimer, Harald, Wolf, John A., Twyman, Roy, Whittemore, Vicky, Wilcox, Karen S., Klein, Brian

“…Epilepsy is one of the most common chronic brain diseases and is often associated with cognitive, behavioral, or other medical conditions. The need for…”
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Applicability of in vitro-in vivo translation of cathepsin K inhibition from animal species to human with the use of free-drug hypothesis by Ma, Bennett, Luo, Bin, Euler, Danielle H., Cusick, Tara E., Wesolowski, Gregg, Glantschnig, Helmut, Duong, Le T., Ou, Yangsi, Carroll, Steven S., Lubbers, Laura S.

“…The correlation of in vitro inhibition of cathepsin K (CatK) activity and in vivo suppression of collagen I biomarkers was examined with three selective CatK…”
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A team science approach for the preclinical and clinical characterization and biomarker development for post‐traumatic epilepsy by Iyengar, Sloka S., Lubbers, Laura S., Harte‐Hargrove, Lauren, Churn, Severn B., Coulter, Douglas, Hunt, Amanda, Kapur, Jaideep, Lowenstein, Daniel, Martin, Renee Hebert, McNamara, James, Umoh, Nsini, White, H. Steve, Whittemore, Vicky, Wright, David W., Bacskai, Brian, Bambrick, Michael, Browning, Jack L., Butler, Mitchell, Carroll, Rona, Costine‐Bartell, Beth A., Davis, Jared, Di Sapia, Rossella, Duhaime, Ann‐Christine, Geraghty, Joseph R., Golemb, Bryan, Gudenschwager, Basso E. K., Gugger, James J., Johnson, Mark, Johnson, Victoria, Klein, Pavel, Kobeissy, Firas, Lillis, Kyle, Loeb, Jeffrey A., Maharathi, Biswajit, Mahmutovic, Dzenis, Martinez‐Ramirez, Luis, Mikhaeil‐Demo, Yara, Moro, Federico, Normoyle, Kieran, Olsen, Michelle L., Patel, Dipan C., Raiyyani, Rehan, Ravizza, Teresa, Rizzi, Massimo, Robel, Stefanie, Serafini, Anna, Shandra, Oleksii, Sontheimer, Harald, Staley, Kevin, Stewart, William, Talos, Delia M., Testai, Fernando, Theus, Michelle, Ulyanova, Alexandra, VandeVord, Pamela, Vezzani, Annamaria, Volanth, Troy, Wagner, Amy K., Wang, Kevin K. W., Wolf, John, Wong, Jensen, Zanier, Elisa

“…Objective Post‐traumatic epilepsy (PTE) is an acquired epilepsy that develops in the months or years following a traumatic brain injury (TBI) and can lead to…”
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Nuclear and Extranuclear Estrogen Binding Sites in the Rat Forebrain and Autonomic Medullary Areas by Milner, Teresa A, Lubbers, Laura S, Alves, Stephen E, McEwen, Bruce S

“…Immunocytochemical studies have shown that nuclear and extranuclear estrogen receptors (ERs) are present in several extrahypothalamic brain regions. The goal…”
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Preclinical evaluation of [11C]L‐235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone by Bennacef, Idriss, Rubins, Daniel, Riffel, Kerry, Williams, Mangay, Posavec, Diane J., Holahan, Marie A., Purcell, Mona L., Haley, Hyking D., Wolf, Mary, Stachel, Shawn J., Lubbers, Laura S., Wesolowski, Gregg A., Duong, Le T., Hamill, Terence G., Evelhoch, Jeffrey L., Hostetler, Eric D.

“…The cathepsin K (CatK) enzyme is abundantly expressed in osteoclasts, and CatK inhibitors have been developed for the treatment of osteoporosis. In our effort…”
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Determination of in Vivo Enzyme Occupancy Utilizing Inhibitor Dissociation Kinetics by Murphy, Dennis J, Ou, Yangsi, Euler, Danielle H, Wessner, Keith, Adamski, Sharon, Luo, Bin, Wesolowski, Gregg A, Vogel, Robert, Glantschnig, Helmut, Lubbers, Laura S, Carroll, Stephen S, Lai, Ming-Tain

“…During drug discovery, assessment of in vivo target occupancy by therapeutic candidates is often required for predicting clinical efficacy. Current strategies…”
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Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site by Rowe, Blake A, Schaffhauser, Hervé, Morales, Sylvia, Lubbers, Laura S, Bonnefous, Celine, Kamenecka, Theodore M, McQuiston, Jeffrey, Daggett, Lorrie P

“…Glutamate is a major neurotransmitter in the central nervous system, and abnormal glutamate neurotransmission has been implicated in many neurological…”
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Estrogen receptor (ER) subtype agonists alter monoamine levels in the female rat brain by Lubbers, Laura S., Zafian, Peter T., Gautreaux, Claris, Gordon, Marisa, Alves, Stephen E., Correa, Lucia, Lorrain, Daniel S., Hickey, Gerard J., Luine, Victoria

“…We assessed the effects of subtype-selective ER agonists on monoamine levels in discrete regions of the female rat brain. Ovariectomized (ovx) rats were…”
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Suppression of cathepsin K biomarker in synovial fluid as a free-drug–driven process by Ma, Bennett, Wesolowski, Gregg, Luo, Bin, Lifsted, Traci, Wessner, Keith, Adamson, Gary, Glantschnig, Helmut, Lubbers, Laura S

“…Cathepsin K (CatK) inhibitors exhibited chondroprotective and pain-reducing effects in animal models, however, improvements were relatively modest at dose…”
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A team science approach to discover novel targets for infantile spasms (IS) by Lubbers, Laura, Iyengar, Sloka S., Vezzani, Annamaria, Berg, Anne T, Lowenstein, Daniel H, Klitgaard, Henrik, Goodkin, Howard P, Rho, Jong M, Katsarou, Anna Maria, Pirone, Antonella, Galanopoulou, Aristea S, Dulla, Chris, Nordli, Douglas R, Iacobas, Dumitru A, Sherr, Elliott, Cloyd, James, Veliskova, Jana, Noebels, Jeff L, Millichap, John J, Swann, John W, Koh, Sookyung, Velisek, Libor, Coles, Lisa, Patel, Manisha, Siehr, Meagan S, Jacob, Michele, Seo, Ryan, Heischmann, Svenja, Moshe, Solomon L, Chachua, Tamar, Brima, Tufikameni, Mowrey, Wenzhu B., Steve White, H, Milder, Julie

“…Infantile spasms (IS) is a devastating epilepsy syndrome that typically begins in the first year of life. Symptoms consist of stereotypical spasms,…”
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Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit by Chen, Zhu, Luo, Bin, Cai, Tian-Quan, Thankappan, Anil, Xu, Yiming, Wu, Weizhen, DiMuzio, Jillian, Lifsted, Traci, DiPietro, Marty, Disa, Jyoti, Ng, Bruce, Leander, Karen, Clark, Seth, Hoos, Lizbeth, Zhou, Yuchen, Jochnowitz, Nina, Jachec, Christine, Szczerba, Peter, Gindy, Marian E, Strapps, Walter, Sepp-Lorenzino, Laura, Seiffert, Dietmar A, Lubbers, Laura, Tadin-Strapps, Marija

“…The present study aimed at establishing feasibility of delivering short interfering RNA (siRNA) to target the coagulation cascade in rat and rabbit, two…”
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Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists by Melamed, Jeffrey Y., Zartman, Amy E., Kett, Nathan R., Gotter, Anthony L., Uebele, Victor N., Reiss, Duane R., Condra, Cindra L., Fandozzi, Christine, Lubbers, Laura S., Rowe, Blake A., McGaughey, Georgia B., Henault, Martin, Stocco, Rino, Renger, John J., Hartman, George D., Bilodeau, Mark T., Trotter, B. Wesley

“…Medicinal chemistry efforts have identified a quinolinone class of potent NPSR antagonists that readily cross the blood–brain barrier. Optimization efforts…”
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Differential Mass Spectrometry of Rat Plasma Reveals Proteins That Are Responsive to 17β-Estradiol and a Selective Estrogen Receptor Modulator PPT by Zhao, Xuemei, Deyanova, Ekaterina G, Lubbers, Laura S, Zafian, Pete, Li, Jenny J, Liaw, Andy, Song, Qinghua, Du, Yi, Settlage, Robert E, Hickey, Gerry J, Yates, Nathan A, Hendrickson, Ronald C

“…Estrogens are a class of steroid hormones that interact with two related but distinct nuclear receptors, estrogen receptor (ER) α and β. To identify potential…”
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MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice by Dillon, Gregory M, Lubbers, Laura S, Ferguson, Mitchell T, Lao, Julie Z, Huang, Ruey-Ruey C, Xiao, Jing C, Fong, Tung M, Hale, Jeffrey J, Rupprecht, Kathleen, Miao, Shouwu, Rowe, Blake A, Kornecook, Thomas J, Dodart, Jean-Cosme

“…Cannabinoid receptors (CBRs) play an important role in a variety of physiological functions and have been considered drug targets for obesity and psychiatric…”
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PISA, A novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ by Lubbers, Laura S., Rowe, Blake A., Hodge, Lisa M., Browne, Susan E., Gundersdorf, Richard, Jones, Philip, Hess, Fred J., Reynolds, Ian J.

“…Poly ADP-ribose polymerase (PARP) maintains genomic integrity by repairing DNA strand breaks, however over-activation of PARP following neural tissue injury is…”
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Estrogen Receptor β Messenger Ribonucleic Acid Expression in the Forebrain of Proestrous, Pregnant, and Lactating Female Rats by Gréco, Béatrice, Lubbers, Laura S, Blaustein, Jeffrey D

“…Estrogen receptor (ER)β is present in hypothalamic and limbic neurons of female rat brains, but little is known about its regulation under physiological…”
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