Search Results - "Lubbers, Ellen"

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age by Xu, Ming, Tchkonia, Tamara, Ding, Husheng, Ogrodnik, Mikolaj, Lubbers, Ellen R., Pirtskhalava, Tamar, White, Thomas A., Johnson, Kurt O., Stout, Michael B., Mezera, Vojtech, Giorgadze, Nino, Jensen, Michael D., LeBrasseur, Nathan K., Kirkland, James L.

“…Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of…”
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Roles and Regulation of Protein Phosphatase 2A (PP2A) in the Heart by Lubbers, Ellen R, Mohler, Peter J

“…Abstract Reversible protein phosphorylation is central to a variety of cardiac processes including excitation-contraction coupling, Ca 2 + handling, cell…”
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Advancing our understanding of AnkRD1 in cardiac development and disease by Murphy, Nathaniel P, Lubbers, Ellen R, Mohler, Peter J

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The Role of GH in Adipose Tissue: Lessons from Adipose-Specific GH Receptor Gene-Disrupted Mice by List, Edward O, Berryman, Darlene E, Funk, Kevin, Gosney, Elahu S, Jara, Adam, Kelder, Bruce, Wang, Xinyue, Kutz, Laura, Troike, Katie, Lozier, Nicholas, Mikula, Vincent, Lubbers, Ellen R, Zhang, Han, Vesel, Clare, Junnila, Riia K, Frank, Stuart J, Masternak, Michal M, Bartke, Andrzej, Kopchick, John J

“…GH receptor (GHR) gene-disrupted mice (GHR−/−) have provided countless discoveries as to the numerous actions of GH. Many of these discoveries highlight the…”
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Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy by Misra, Chaitali, Bangru, Sushant, Lin, Feikai, Lam, Kin, Koenig, Sara N., Lubbers, Ellen R., Hedhli, Jamila, Murphy, Nathaniel P., Parker, Darren J., Dobrucki, Lawrence W., Cooper, Thomas A., Tajkhorshid, Emad, Mohler, Peter J., Kalsotra, Auinash

“…Myotonic dystrophy type 1 (DM1) is a multisystemic genetic disorder caused by the CTG repeat expansion in the 3′-untranslated region of DMPK gene. Heart…”
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Arrhythmogenic Substrates for Atrial Fibrillation in Obesity by Lubbers, Ellen R, Price, Morgan V, Mohler, Peter J

“…Global obesity rates have nearly tripled since 1975. This obesity rate increase is mirrored by increases in atrial fibrillation (AF) that now impacts nearly…”
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Protein Phosphatase 2A Regulates Cardiac Na+ Channels by El Refaey, Mona, Musa, Hassan, Murphy, Nathaniel P, Lubbers, Ellen R, Skaf, Michel, Han, Mei, Cavus, Omer, Koenig, Sara N, Wallace, Michael J, Gratz, Daniel, Bradley, Elisa, Alsina, Katherina M, Wehrens, Xander H.T, Hund, Thomas J, Mohler, Peter J

“…RATIONALE:Voltage-gated Na channel (INa) function is critical for normal cardiac excitability. However, the Na channel late component (INa,L) is directly…”
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Heterogeneity Among White Adipose Tissue Depots in Male C57BL/6J Mice by Sackmann‐Sala, Lucila, Berryman, Darlene E., Munn, Rachel D., Lubbers, Ellen R., Kopchick, John J.

“…The widespread prevalence of obesity has lead to extensive research on white adipose tissue (WAT), which frequently uses the C57BL/6J mouse strain as a model…”
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Male Bovine GH Transgenic Mice Have Decreased Adiposity With an Adipose Depot-Specific Increase in Immune Cell Populations by Benencia, Fabian, Harshman, Stephanie, Duran-Ortiz, Silvana, Lubbers, Ellen R, List, Edward O, Householder, Lara, Al-Naeeli, Mawadda, Liang, Xiaoyu, Welch, Lonnie, Kopchick, John J, Berryman, Darlene E

“…White adipose tissue (WAT) is composed of mature adipocytes and a stromal vascular fraction (SVF), which contains a variety of cells, including immune cells…”
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Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice by Stout, Michael B, Tchkonia, Tamara, Pirtskhalava, Tamar, Palmer, Allyson K, List, Edward O, Berryman, Darlene E, Lubbers, Ellen R, Escande, Carlos, Spong, Adam, Masternak, Michal M, Oberg, Ann L, LeBrasseur, Nathan K, Miller, Richard A, Kopchick, John J, Bartke, Andrzej, Kirkland, James L

“…The aging process is associated with the development of several chronic diseases. White adipose tissue (WAT) may play a central role in age-related disease…”
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GH action influences adipogenesis of mouse adipose tissue-derived mesenchymal stem cells by Olarescu, Nicoleta C, Berryman, Darlene E, Householder, Lara A, Lubbers, Ellen R, List, Edward O, Benencia, Fabian, Kopchick, John J, Bollerslev, Jens

“…GH influences adipocyte differentiation, but both stimulatory and inhibitory effects have been described. Adipose tissue-derived mesenchymal stem cells…”
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Advancements in the Use of Gene Therapy for Cardiac Arrhythmia by Murphy, Nathaniel P., B.A, Lubbers, Ellen R., B.S, Mohler, Peter J., Ph.D

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Defining new mechanistic roles for αII spectrin in cardiac function by Lubbers, Ellen R., Murphy, Nathaniel P., Musa, Hassan, Huang, Claire Yu-Mei, Gupta, Rohan, Price, Morgan V., Han, Mei, Daoud, Georges, Gratz, Daniel, El Refaey, Mona, Xu, Xianyao, Hoeflinger, Nicole K., Friel, Emma L., Lancione, Peter, Wallace, Michael J., Cavus, Omer, Simmons, Samantha L., Williams, Jordan L., Skaf, Michel, Koenig, Sara N., Janssen, Paul M.L., Rasband, Matthew N., Hund, Thomas J., Mohler, Peter J.

“…Spectrins are cytoskeletal proteins essential for membrane biogenesis and regulation and serve critical roles in protein targeting and cellular signaling. αII…”
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Growth Hormone Receptor Antagonist Transgenic Mice Are Protected From Hyperinsulinemia and Glucose Intolerance Despite Obesity When Placed on a HF Diet by Yang, Tianxu, Householder, Lara A, Lubbers, Ellen R, List, Edward O, Troike, Katie, Vesel, Clare, Duran-Ortiz, Silvana, Kopchick, John J, Berryman, Darlene E

“…Reduced GH levels have been associated with improved glucose metabolism and increased longevity despite obesity in multiple mouse lines. However, one mouse…”
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Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity? by Lubbers, Ellen R, List, Edward O, Jara, Adam, Sackman-Sala, Lucila, Cordoba-Chacon, Jose, Gahete, Manuel D, Kineman, Rhonda D, Boparai, Ravneet, Bartke, Andrzej, Kopchick, John J, Berryman, Darlene E

“…Adiponectin is positively correlated with longevity and negatively correlated with many obesity-related diseases. While there are several circulating forms of…”
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A dwarf mouse model with decreased GH/IGF-1 activity that does not experience life-span extension: potential impact of increased adiposity, leptin, and insulin with advancing age by Berryman, Darlene E, Lubbers, Ellen R, Magon, Vishakha, List, Edward O, Kopchick, John J

“…Reduced growth hormone (GH) action is associated with extended longevity in many vertebrate species. GH receptor (GHR) null (GHR(-)(/-)) mice, which have a…”
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Correction: Defining new mechanistic roles for α II spectrin in cardiac function by Lubbers, Ellen R., Murphy, Nathaniel P., Musa, Hassan, Huang, Claire Yu-Mei, Gupta, Rohan, Price, Morgan V., Han, Mei, Daoud, Georges E., Gratz, Daniel, El Refaey, Mona, Xu, Xianyao, Hoeflinger, Nicole K., Friel, Emma L., Lancione, Peter, Wallace, Michael J., Cavus, Omer, Simmons, Samantha L., Williams, Jordan L., Skaf, Michel, Koenig, Sara N., Janssen, Paul M.L., Rasband, Matthew N., Hund, Thomas J., Mohler, Peter J.

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Common human ANK2 variant confers in vivo arrhythmia phenotypes by Musa, Hassan, PhD, Murphy, Nathaniel P., BS, Curran, Jerry, PhD, Higgins, John D., BS, Webb, Tyler R, Makara, Michael A., PhD, Wright, Patrick, BS, Lancione, Peter J., BS, Lubbers, Ellen R., BS, Healy, Jane A., BS, Smith, Sakima A., MD, Bennett, Vann, MD, PhD, Hund, Thomas J., PhD, Kline, Crystal F., PhD, Mohler, Peter J., PhD

“…Background Human ANK2 (ankyrin-B) loss-of-function variants are directly linked with arrhythmia phenotypes. However, in atypical non–ion channel arrhythmia…”
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Defining the Links Between Oxidative Stress–Based Biomarkers and Postoperative Atrial Fibrillation by Lubbers, Ellen R., Murphy, Nathaniel P., Mohler, Peter J.

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Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence by Comisford, Ross, Lubbers, Ellen R, Householder, Lara A, Suer, Ozan, Tchkonia, Tamara, Kirkland, James L, List, Edward O, Kopchick, John J, Berryman, Darlene E

“…Growth hormone (GH)-resistant/deficient mice experience improved glucose homeostasis and substantially increased lifespan. Recent evidence suggests that…”
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