Search Results - "Lubbehusen, Penny"

Viracept (Nelfinavir Mesylate, AG1343):  A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease by Kaldor, Stephen W, Kalish, Vincent J, Davies, Jay F, Shetty, Bhasker V, Fritz, James E, Appelt, Krzysztof, Burgess, Jeffrey A, Campanale, Kristina M, Chirgadze, Nickolay Y, Clawson, David K, Dressman, Bruce A, Hatch, Steven D, Khalil, Deborah A, Kosa, Maha B, Lubbehusen, Penny P, Muesing, Mark A, Patick, Amy K, Reich, Siegfried H, Su, Kenneth S, Tatlock, John H

“…Using a combination of iterative structure-based design and an analysis of oral pharmacokinetics and antiviral activity, AG1343 (Viracept, nelfinavir…”
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Potent Human Immunodeficiency Virus Type 1 Protease Inhibitors That Utilize Noncoded d -Amino Acids as P 2 /P 3 Ligands by Jungheim, Louis N., Shepherd, Timothy A., Baxter, Angela J., Burgess, Jeffrey, Hatch, Steven D., Lubbehusen, Penny, Wiskerchen, MaryAnn, Muesing, Mark A.

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Potent Human Immunodeficiency Virus Type 1 Protease Inhibitors That Utilize Noncoded d-Amino Acids as P2/P3 Ligands by Jungheim, Louis N, Shepherd, Timothy A, Baxter, Angela J, Burgess, Jeffrey, Hatch, Steven D, Lubbehusen, Penny, Wiskerchen, MaryAnn, Muesing, Mark A

“…Noncoded d-amino acids have been designed to replace the quinaldic amide−asparaginyl moiety (P2/P3 ligand) found in several potent human immunodeficiency virus…”
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Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease by Kaldor, Stephen W., Dressman, Bruce A., Hammond, Marlys, Appelt, Krzysztof, Burgess, Jeffrey A., Lubbehusen, Penny P., Muesing, Mark A., Hatch, Steven D., Wiskerchen, Mary Ann, Baxter, Angela J.

“…Using the X-ray crystal structure of the inhibitor 1 complexed to HIV-1 protease, a new series of HIV-1 protease inhibitors was developed incorporating…”
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