Search Results - "Lubahn, D B"

Increased Adipose Tissue in Male and Female Estrogen receptor-α Knockout Mice by Heine, P. A., Taylor, J. A., Iwamoto, G. A., Lubahn, D. B., Cooke, P. S.

“…Estrogen regulates the amount of white adipose tissue (WAT) in females, but its role in males and whether WAT effects involve estrogen receptor-α (ERα ) or ERβ…”
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A role for oestrogens in the male reproductive system by Hess, Rex A, Bunick, David, Lee, Ki-Ho, Bahr, Janice, Taylor, Julia A, Korach, Kenneth S, Lubahn, Dennis B

“…Oestrogen is considered to be the 'female' hormone, whereas testosterone is considered the 'male' hormone. However, both hormones are present in both sexes…”
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Estrogen receptor specificity for the effects of estrogen in ovariectomized mice by Lindberg, MK, Weihua, Z, Andersson, N, Moverare, S, Gao, H, Vidal, O, Erlandsson, M, Windahl, S, Andersson, G, Lubahn, DB, Carlsten, H, Dahlman-Wright, K, Gustafsson, JA, Ohlsson, C

“…Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), alpha and…”
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Stromal Estrogen Receptors Mediate Mitogenic Effects of Estradiol on Uterine Epithelium by Cooke, P. S., Buchanan, D. L., Young, P., Setiawan, T., Brody, J., Korach, K. S., Taylor, J., Lubahn, D. B., Cunha, G. R.

“…Estradiol-17 β (E2) acts through the estrogen receptor (ER) to regulate uterine growth and functional differentiation. To determine whether E2 elicits…”
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Alteration of Reproductive Function but Not Prenatal Sexual Development After Insertional Disruption of the Mouse Estrogen Receptor Gene by Lubahn, Dennis B., Moyer, Jeffrey S., Golding, Thomas S., Couse, John F., Korach, Kenneth S., Smithies, Oliver

“…Estrogen receptor and its ligand, estradiol, have long been thought to be essential for survival, fertility, and female sexual differentiation and development…”
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Intraovarian actions of oestrogen by Rosenfeld, CS, Wagner, JS, Roberts, RM, Lubahn, DB

“…Oestrogen regulates several hypothalamic and pituitary hormones, which in turn control ovarian functions. Oestrogen and its metabolites, such as…”
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In Vitro and in Vivo Regulation of Antioxidant Response Element-Dependent Gene Expression by Estrogens by Ansell, P. J, Espinosa-Nicholas, C, Curran, E. M, Judy, B. M, Philips, B. J, Hannink, M, Lubahn, D. B

“…Understanding estrogen’s regulation of phase II detoxification enzymes is important in explaining how estrogen exposure increases the risk of developing…”
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Estrogen Receptor-Dependent Sexual Differentiation of Dopaminergic Neurons in the Preoptic Region of the Mouse by Simerly, R. B., Zee, M. C., Pendleton, J. W., Lubahn, D. B., Korach, K. S.

“…Although it has been known for some time that estrogen exerts a profound influence on brain development a definitive demonstration of the role of the classical…”
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Analysis of temporal changes in the expression of estrogen-regulated genes in the uterus by Watanabe, H, Suzuki, A, Kobayashi, M, Takahashi, E, Itamoto, M, Lubahn, DB, Handa, H, Iguchi, T

“…In order to understand early events caused by estrogen in vivo, temporal uterine gene expression profiles at early stages were examined using DNA microarray…”
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Uterine Responsiveness to Estradiol and DNA Methylation Are Altered by Fetal Exposure to Diethylstilbestrol and Methoxychlor in CD-1 Mice: Effects of Low versus High Doses by Alworth, L.C., Howdeshell, K.L., Ruhlen, R.L., Day, J.K., Lubahn, D.B., Huang, T.H-M., Besch-Williford, C.L., vom Saal, F.S.

“…We examined the effects on female CD-1 mice of fetal exposure to low doses of the drug diethylstilbestrol (DES) (0.1 μg/kg/day) and the insecticide…”
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Tissue-specific estrogenic and non-estrogenic effects of a xenoestrogen, nonylphenol by Watanabe, H, Suzuki, A, Goto, M, Lubahn, DB, Handa, H, Iguchi, T

“…Alkylphenols perturb the endocrine system and are considered to have weak estrogenic activities. Although it is known that nonylphenol can bind weakly to the…”
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Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man by Smith, Eric P, Boyd, Jeff, Frank, Graeme R, Takahashi, Hiroyuki, Cohen, Robert M, Specker, Bonny, Williams, Timothy C, Lubahn, Dennis B, Korach, Kenneth S

“…The actions of adrenal and gonadal steroids, thyroid hormone, and vitamin D are mediated by receptors encoded by a family of related genes. Mutations of…”
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Similarities and differences in uterine gene expression patterns caused by treatment with physiological and non-physiological estrogens by Watanabe, H, Suzuki, A, Kobayashi, M, Lubahn, DB, Handa, H, Iguchi, T

“…Administration of physiological and non-physiological estrogens during pregnancy or after birth is known to have adverse effects on the development of the…”
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Dietary soy phytoestrogens and ERα signalling modulate interferon gamma production in response to bacterial infection by CURRAN, E. M., JUDY, B. M., NEWTON, L. G., LUBAHN, D. B., ROTTINGHAUS, G. E., MACDONALD, R. S., FRANKLIN, C., ESTES, D. M.

“…SUMMARY Diets rich in soy phytoestrogens have many potential health benefits but isoflavones such as genistein may suppress cell mediated immune function. The…”
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Mechanism of estrogen action : Lessons from the estrogen receptor-α knockout mouse by COOKE, P. S, BUCHANAN, D. L, LUBAHN, D. B, CUNHA, G. R

“…Estradiol-17 beta (E sub(2)) stimulates uterine and vaginal epithelial proliferation in vivo. E sub(2) also plays a critical role in other aspects of uterine…”
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Masculine Sexual Behavior Is Disrupted in Male and Female Mice Lacking a Functional Estrogen Receptor α Gene by Wersinger, Scott R, Sannen, Koen, Villalba, Constanza, Lubahn, Dennis B, Rissman, Emilie F, De Vries, Geert J

“…Masculine sexual behavior is regulated by testosterone (T). However, T can be metabolized to form estrogens or other androgens, which then activate their own…”
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Sequence of the Intron/Exon Junctions of the Coding Region of the Human Androgen Receptor Gene and Identification of a Point Mutation in a Family with Complete Androgen Insensitivity by Lubahn, Dennis B., Brown, Terry R., Simental, Jorge A., Higgs, Henry N., Migeon, Claude J., Wilson, Elizabeth M., French, Frank S.

“…Androgens act through a receptor protein (AR) to mediate sex differentiation and development of the male phenotype. We have isolated the eight exons in the…”
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Decreased growth in angus steers with a short TG-microsatellite allele in the P1 promoter of the growth hormone receptor gene by Hale, C. S, Herring, W. O, Shibuya, H, Lucy, M. C, Lubahn, D. B, Keisler, D. H, Johnson, G. S

“…A polymorphic TG-repeat microsatellite is located 90 base pairs upstream from a major transcription start site in the bovine growth hormone receptor gene. A…”
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Estrogen receptor-α deficiency attenuates autoimmune disease in (NZB × NZW)F1 mice by Bynoté, K K, Hackenberg, J M, Korach, K S, Lubahn, D B, Lane, P H, Gould, K A

“…Estrogens promote lupus in humans and some mouse models of this disease. Nonetheless, little is known about the role of estrogen receptors in lupus…”
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Identification of Androgen Receptors in Normal Human Osteoblast-Like Cells by Colvard, Douglas S., Eriksen, Erik F., Keeting, Philip E., Wilson, Elizabeth M., Lubahn, Dennis B., French, Frank S., Riggs, B. Lawrence, Spelsberg, Thomas C.

“…The sex steroids, androgens and estrogens, are major regulators of bone metabolism. However, whether these hormones act on bone cells through direct or…”
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