Search Results - "Lušin, Tina Trdan"

Matrixing Designs for Shelf-Life Determination of Parenteral Drug Product: A Comparative Analysis of Full and Reduced Stability Testing Design by Pavčnik, Lara, Locatelli, Igor, Trdan Lušin, Tina, Roškar, Robert

“…This article highlights the applicability of matrixing designs in stability studies for parenteral medications. The traditional approach involves extensive…”
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Forced degradation of tacrolimus and the development of a UHPLC method for impurities determination by Peterka, Tanja Rozman, Lušin, Tina Trdan, Bergles, Jure, Ham, Zoran, Grahek, Rok, Urleb, Uroš

“…An ultra-high performance liquid chromatography method for simultaneous determination of tacrolimus impurities in pharmaceutical dosage forms has been…”
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Development of an Analytical Method for Determination of Related Substances and Degradation Products of Cabotegravir Using Analytical Quality by Design Principles by Kovač, Lidija, Časar, Zdenko, Trdan Lušin, Tina, Roškar, Robert

“…Cabotegravir is one of the newly approved human immunodeficiency virus (HIV) integrase enzyme inhibitors used for the prevention and treatment of HIV…”
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Evaluation of bisphenol A glucuronidation according to UGT1A128 polymorphism by a new LC–MS/MS assay by Trdan Lušin, Tina, Roškar, Robert, Mrhar, Aleš

“…The endocrine disruptor bisphenol A (BPA) is a frequently used chemical in the manufacture of consumer products. In humans, BPA is extensively metabolized to…”
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Co-crystals, Salts or Mixtures of Both? The Case of Tenofovir Alafenamide Fumarates by Lengauer, Hannes, Makuc, Damjan, Šterk, Damjan, Perdih, Franc, Pichler, Arthur, Trdan Lušin, Tina, Plavec, Janez, Časar, Zdenko

“…Tenofovir alafenamide fumarate (TAF) is the newest prodrug of tenofovir that constitutes several drug products used for the treatment of HIV/AIDS. Although the…”
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Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene by Trdan Lušin, Tina, Stieger, Bruno, Marc, Janja, Mrhar, Aleš, Trontelj, Jurij, Zavratnik, Andrej, Ostanek, Barbara

“…Raloxifene, a selective estrogen receptor modulator, exhibits quite large and unexplained interindividual variability in pharmacokinetics and pharmacodynamics…”
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Fast and Simple LC-MS/MS Method for Rifampicin Quantification in Human Plasma by Trontelj, Jurij, Kristl, Albin, Grabnar, Iztok, Faganeli, Nataša, Trdan Lušin, Tina, Klančar Andrejc, Anita, Roškar, Robert, Temova Rakuša, Žane, Mrhar, Aleš

“…A simple, fast, and cost-effective LC-MS/MS method for quantification of rifampicin in human plasma was developed and fully validated. The plasma samples…”
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Understanding of cabotegravir degradation through isolation and characterization of key degradation products and kinetic studies by Kovač, Lidija, Črnugelj, Martin, Roškar, Robert, Trdan Lušin, Tina, Časar, Zdenko

“…[Display omitted] •Cabotegravir stability characteristics were established under stress conditions.•Key degradation products of cabotegravir formed under…”
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Raloxifene Glucuronidation in Human Intestine, Kidney, and Liver Microsomes and in Human Liver Microsomes Genotyped for the UGT1A1 28 Polymorphism by Trdan Lušin, Tina, Trontelj, Jurij, Mrhar, Aleš

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Raloxifene Glucuronidation in Human Intestine, Kidney, and Liver Microsomes and in Human Liver Microsomes Genotyped for the UGT1A128 Polymorphism by TINA TRDAN LUSIN, TRONTELJ, Jurij, MRHAR, Aleš

“…Raloxifene, a selective estrogen receptor modulator, exhibits quite large interindividual variability in pharmacokinetics and pharmacodynamics. In women,…”
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Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment by Trdan Lušin, Tina, Mrhar, Aleš, Stieger, Bruno, Kullak-Ublick, Gerd A, Marc, Janja, Ostanek, Barbara, Zavratnik, Andrej, Kristl, Albin, Berginc, Katja, Delić, Katja, Trontelj, Jurij

“…Raloxifene exhibits a large and unexplained interindividual variability in its pharmacokinetics and pharmacodynamics. The aim of our study was to identify…”
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Efflux and uptake transporters involved in the disposition of bazedoxifene by Lušin, Tina Trdan, Mrhar, Aleš, Stieger, Bruno, Kristl, Albin, Berginc, Katja, Trontelj, Jurij

“…Bazedoxifene, a novel selective estrogen receptor modulator, has complex pharmacokinetics with rapid absorption, high metabolic clearance, low oral…”
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In vitro bioactivation of bazedoxifene and 2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol in human liver microsomes by Lušin, Tina Trdan, Tomašić, Tihomir, Trontelj, Jurij, Mrhar, Aleš, Peterlin-Mašič, Lucija

“…[Display omitted] . ► We examined in vitro bioactivation of bazedoxifene and N-dealkylated fragment of bazedoxifene in HLM and with P450 isozymes. ►…”
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Inverse correlation of carotid intima-media thickness with raloxifene serum levels in osteoporosis by Lušin, Tina Trdan, Mrhar, Aleš, Marc, Janja, Trontelj, Jurij, Zavratnik, Andrej, Žegura, Branka, Pfeifer, Marija, Ostanek, Barbara

“…Summary Background Raloxifene is a selective oestrogen receptor modulator with effects on bone and breast cancer and cardiovascular disease risk. The aim of…”
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Evaluation of bisphenol A glucuronidation according to UGT1A1 28 polymorphism by a new LC–MS/MS assay by Trdan Lušin, Tina, Roškar, Robert, Mrhar, Aleš

“…Abstract The endocrine disruptor bisphenol A (BPA) is a frequently used chemical in the manufacture of consumer products. In humans, BPA is extensively…”
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