Search Results - "Lu, Zhonghui"

Characteristics of Vegetation Photosynthesis under Flash Droughts in the Major Agricultural Areas of Southern China by Zhang, Yuqing, Liu, Fengwu, Liu, Taizheng, Chen, Changchun, Lu, Zhonghui

“…Flash droughts adversely affect agriculture and ecosystems due to their rapid depletion of soil moisture (SM). However, few studies assessed the impacts of…”
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Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR by Hu, Jinhui, Chen, Li, Lu, Zhonghui, Yao, Han, Hu, Yunfei, Feng, Luanqi, Pang, Yanqing, Wu, Jia-Qiang, Yu, Zhiling, Chen, Wen-Hua

“…Cellular mesenchymal-epithelial transition factor (c-Met), an oncogenic transmembrane receptor tyrosine kinase (RTK), plays an essential role in cell…”
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Reliability and validity of the repetitive behavior scale-revised for young Chinese children with autism spectrum disorder in Jiangxi Province by Luo, Xiu, Xiong, Yaoyao, Gu, Mei, Huang, Liyun, Lu, Zhonghui, Zhong, Xia, Zou, Shipu

“…Restricted and repetitive behaviors (RRBs) are one of the two main diagnostic features of autism spectrum disorder (ASD). To date, a growing body of research…”
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α,β-Cyclic-β-benzamido hydroxamic acids: Novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-α converting enzyme (TACE) by Ott, Gregory R., Asakawa, Naoyuki, Lu, Zhonghui, Liu, Rui-Qin, Covington, Maryanne B., Vaddi, Krishna, Qian, Mingxin, Newton, Robert C., Christ, David D., Traskos, James M., Decicco, Carl P., Duan, James J.-W.

“…Selective inhibitors of TNF-α Converting Enzyme (TACE) based on novel α,β-cyclic-β-benzamido hydroxamic acids have been synthesized and evaluated. Selective…”
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Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors by Duan, James J.-W., Chen, Lihua, Lu, Zhonghui, Xue, Chu-Biao, Liu, Rui-Qin, Covington, Maryanne B., Qian, Mingxin, Wasserman, Zelda R., Vaddi, Krishna, Christ, David D., Trzaskos, James M., Newton, Robert C., Decicco, Carl P.

“…β-Benzamido hydroxamic acids were discovered as potent TACE inhibitors. A computer model was constructed to help understanding the binding activities and…”
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Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-α converting enzyme by Duan, James J.-W., Lu, Zhonghui, Wasserman, Zelda R., Liu, Rui-Qin, Covington, Maryanne B., Decicco, Carl P.

“…[Display omitted] New inhibitors of tumor necrosis factor-α converting enzyme (TACE) were discovered with a pyrimidine-2,4,6-trione in place of the commonly…”
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An unsupervised data mining-based framework for evaluation and optimization of operation strategy of HVAC system by Tian, Zhe, Lu, Zhonghui, Lu, Yakai, Zhang, Qiang, Lin, Xinyi, Niu, Jide

“…The evaluation and optimization of existing operation strategies are significant for energy-saving in heating, ventilation, and air conditioning (HVAC)…”
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Discovery of N-Hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE) by Duan, James J.-W., Lu, Zhonghui, Xue, Chu-Biao, He, Xiaohua, Seng, Jennifer L., Roderick, John J., Wasserman, Zelda R., Liu, Rui-Qin, Covington, Maryanne B., Magolda, Ronald L., Newton, Robert C., Trzaskos, James M., Decicco, Carl P.

“…New inhibitors of tumor necrosis factor-α converting enzyme (TACE) were discovered using an N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamide scaffold. The series…”
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Population exposure to concurrent daytime and nighttime heatwaves in Huai River Basin, China by Zhang, Yuqing, Mao, Guangxiong, Chen, Changchun, Lu, Zhonghui, Luo, Zhen, Zhou, Wenting

“…•Severe heatwaves are likely to occur in the southeastern parts of the basin.•Various indices of heatwaves show significant upward trends from 1987 to…”
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Design, Synthesis, and Antitumor Efficacy of Substituted 2‑Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2 by Chen, Li, Hu, Yunfei, Lu, Zhonghui, Lin, Zeyin, Li, Lanqing, Wu, Jia-Qiang, Yu, Zhi-Ling, Wang, Chunye, Chen, Wen-Hua, Hu, Jinhui

“…Preclinical and clinical studies have demonstrated the synergistic effect of microtubule-targeting agents in combination with Janus kinase 2 (JAK2) inhibitors,…”
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Anticancer efficacy triggered by synergistically modulating the homeostasis of anions and iron: Design, synthesis and biological evaluation of dual-functional squaramide-hydroxamic acid conjugates by Zhi, Hai-Tao, Lu, Zhonghui, Chen, Li, Wu, Jia-Qiang, Li, Lanqing, Hu, Jinhui, Chen, Wen-Hua

“…[Display omitted] •Dual-functional squaramide-hydroxamic acid conjugates were designed and synthesized.•Compound 16 exhibited potent antiproliferative activity…”
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Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches by Xiao, Hai-Yun, Li, Ning, Duan, James J.-W, Jiang, Bin, Lu, Zhonghui, Ngu, Khehyong, Tino, Joseph, Kopcho, Lisa M, Lu, Hao, Chen, Jing, Tebben, Andrew J, Sheriff, Steven, Chang, ChiehYing Y, Yanchunas, Joseph, Calambur, Deepa, Gao, Mian, Shuster, David J, Susulic, Vojkan, Xie, Jenny H, Guarino, Victor R, Wu, Dauh-Rurng, Gregor, Kurt R, Goldstine, Christine B, Hynes, John, Macor, John E, Salter-Cid, Luisa, Burke, James R, Shaw, Patrick J, Dhar, T. G. Murali

“…Scaffold hopping and structure-based drug design were employed to identify substituted 4-aminoquinolines and 4-aminonaphthyridines as potent, small molecule…”
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Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists by Duan, James J.-W, Lu, Zhonghui, Jiang, Bin, Stachura, Sylwia, Weigelt, Carolyn A, Sack, John S, Khan, Javed, Ruzanov, Max, Galella, Michael A, Wu, Dauh-Rurng, Yarde, Melissa, Shen, Ding-Ren, Shuster, David J, Borowski, Virna, Xie, Jenny H, Zhang, Lisa, Vanteru, Sridhar, Gupta, Arun Kumar, Mathur, Arvind, Zhao, Qihong, Foster, William, Salter-Cid, Luisa M, Carter, Percy H, Dhar, T. G. Murali

“…A new phenyl (3-phenylpyrrolidin-3-yl)­sulfone series of RORγt inverse agonists was discovered utilizing the binding conformation of previously reported…”
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Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists by Harikrishnan, Lalgudi S., Gill, Patrice, Kamau, Muthoni G., Qin, Lan-Ying, Ruan, Zheming, O'Malley, Daniel, Huynh, Tram, Stachura, Sylwia, Cavallaro, Cullen L., Lu, Zhonghui, J.-W. Duan, James, Weigelt, Carolyn A., Sack, John S., Ruzanov, Max, Khan, Javed, Gururajan, Murali, Wong, Jessica J., Huang, Yanling, Yarde, Melissa, Li, Zhuyin, Chen, Cliff, Sun, Huadong, Borowski, Virna, Murtaza, Anwar, Fink, Brian E.

“…[Display omitted] Substituted benzyloxy aryl compound 2 was identified as an RORγt agonist. Structure based drug design efforts resulted in a potent and…”
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Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists by Lu, Zhonghui, Duan, James J.-W., Xiao, Haiyun, Neels, James, Wu, Dauh-Rurng, Weigelt, Carolyn A., Sack, John S., Khan, Javed, Ruzanov, Max, An, Yongmi, Yarde, Melissa, Karmakar, Ananta, Vishwakrishnan, Sureshbabu, Baratam, Venkata, Shankarappa, Harisha, Vanteru, Sridhar, Babu, Venkatesh, Basha, Mushkin, Kumar Gupta, Arun, Kumaravel, Selvakumar, Mathur, Arvind, Zhao, Qihong, Salter-Cid, Luisa M., Carter, Percy H., Murali Dhar, T.G.

“…[Display omitted] An X-ray crystal structure of one of our previously discovered RORγt inverse agonists bound to the RORγt ligand binding domain revealed that…”
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Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity by Gong, Hua, Weinstein, David S., Lu, Zhonghui, Duan, James J.-W., Stachura, Sylwia, Haque, Lauren, Karmakar, Ananta, Hemagiri, Hemalatha, Raut, Dhanya Kumar, Gupta, Arun Kumar, Khan, Javed, Camac, Dan, Sack, John S., Pudzianowski, Andrew, Wu, Dauh-Rurng, Yarde, Melissa, Shen, Ding-Ren, Borowski, Virna, Xie, Jenny H., Sun, Huadong, D'Arienzo, Celia, Dabros, Marta, Galella, Michael A., Wang, Faye, Weigelt, Carolyn A., Zhao, Qihong, Foster, William, Somerville, John E., Salter-Cid, Luisa M., Barrish, Joel C., Carter, Percy H., Dhar, T.G. Murali

“…[Display omitted] We disclose the optimization of a high throughput screening hit to yield benzothiazine and tetrahydroquinoline sulfonamides as potent RORγt…”
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Discovery of highly potent, selective, covalent inhibitors of JAK3 by Kempson, James, Ovalle, Damaso, Guo, Junqing, Wrobleski, Stephen T., Lin, Shuqun, Spergel, Steven H., Duan, James J.-W., Jiang, Bin, Lu, Zhonghui, Das, Jagabandhu, Yang, Bingwei V., Hynes, John, Wu, Hong, Tokarski, John, Sack, John S., Khan, Javed, Schieven, Gary, Blatt, Yuval, Chaudhry, Charu, Salter-Cid, Luisa M., Fura, Aberra, Barrish, Joel C., Carter, Percy H., Pitts, William J.

“…[Display omitted] A useful and novel set of tool molecules have been identified which bind irreversibly to the JAK3 active site cysteine residue. The design…”
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Discovery of 2,6–difluorobenzyl ether series of phenyl ((R)–3–phenylpyrrolidin–3–yl)sulfones as surprisingly potent, selective and orally bioavailable RORγt inverse agonists by Duan, James J.-W., Jiang, Bin, Lu, Zhonghui, Stachura, Sylwia, Weigelt, Carolyn A., Sack, John S., Khan, Javed, Ruzanov, Max, Wu, Dauh–Rurng, Yarde, Melissa, Shen, Ding–Ren, Zhao, Qihong, Salter–Cid, Luisa M., Carter, Percy H., Murali Dhar, T.G.

“…[Display omitted] In an effort to discover oral inverse agonists of RORγt to treat inflammatory diseases, a new 2,6–difluorobenzyl ether series of cyclopentyl…”
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Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors by Hynes, John, Wu, Hong, Kempson, James, Duan, James J.-W., Lu, Zhonghui, Jiang, Bin, Stachura, Sylwia, Tokarski, John S., Sack, John S., Khan, Javed A., Lippy, Jonathan S., Zhang, Rosemary F., Pitt, Sidney, Shen, Guoxiang, Gillooly, Kate, McIntyre, Kim, Carter, Percy H., Barrish, Joel C., Nadler, Steven G., Salter-Cid, Luisa M., Fura, Aberra, Schieven, Gary L., Pitts, William J., Wrobleski, Stephen T.

“…[Display omitted] A series of potent dual JAK1/3 inhibitors have been developed from a moderately selective JAK3 inhibitor. Substitution at the C6 position of…”
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Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors by Duan, James J-W, Lu, Zhonghui, Jiang, Bin, Yang, Bingwei V, Doweyko, Lidia M, Nirschl, David S, Haque, Lauren E, Lin, Shuqun, Brown, Gregory, Hynes, Jr, John, Tokarski, John S, Sack, John S, Khan, Javed, Lippy, Jonathan S, Zhang, Rosemary F, Pitt, Sidney, Shen, Guoxiang, Pitts, William J, Carter, Percy H, Barrish, Joel C, Nadler, Steven G, Salter-Cid, Luisa M, McKinnon, Murray, Fura, Aberra, Schieven, Gary L, Wrobleski, Stephen T

“…A new class of Janus kinase (JAK) inhibitors was discovered using a rationally designed pyrrolo[1,2-b]pyridazine-3-carboxamide scaffold. Preliminary studies…”
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