Search Results - "Lu, ZengJun"
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Structures of Foot-and-mouth Disease Virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization
Published in PLoS pathogens (01-04-2021)“…The development of a universal vaccine against foot-and-mouth disease virus (FMDV) is hindered by cross-serotype antigenic diversity and by a lack of knowledge…”
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Pseudorabies Virus Glycoproteins E and B Application in Vaccine and Diagnosis Kit Development
Published in Vaccines (Basel) (20-09-2024)“…: Pseudorabies virus (PRV) is a highly infectious pathogen that affects a wide range of mammals and imposes a significant economic burden on the global pig…”
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High-throughput screening unveils nitazoxanide as a potent PRRSV inhibitor by targeting NMRAL1
Published in Nature communications (06-06-2024)“…Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) poses a major threat to the global swine industry, yet effective prevention and control measures…”
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Conserved antigen structures and antibody-driven variations on foot-and-mouth disease virus serotype A revealed by bovine neutralizing monoclonal antibodies
Published in PLoS pathogens (20-11-2023)“…Foot-and-mouth disease virus (FMDV) serotype A is antigenically most variable within serotypes. The structures of conserved and variable antigenic sites were…”
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Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I
Published in PLoS pathogens (28-10-2024)“…Non-structural protein 2 (NSP2) of PRRSV is highly variable and plays crucial roles in the virus's life cycle. To elucidate the function of NSP2 during PRRSV…”
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6
Optimization of wind resistance in commercial vehicles with consideration of sunroof buffeting noise
Published in AIP advances (01-08-2021)“…The aim of this study was to reduce the aerodynamic resistance coefficient of heavy commercial vehicles and buffeting noise that occurs when a sunroof is…”
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Engineering viable foot-and-mouth disease viruses with increased acid stability facilitate the development of improved vaccines
Published in Applied microbiology and biotechnology (01-02-2020)“…Foot-and-mouth disease virus (FMDV), the most acid-unstable virus among picornaviruses , tends to disassemble into pentamers at pH values slightly below…”
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The long non-coding RNA LNC_000397 negatively regulates PRRSV replication through induction of interferon-stimulated genes
Published in Virology journal (05-03-2022)“…Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most significant threats to the global swine industry. It is of great importance to…”
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Rational design and efficacy of a multi-epitope recombinant protein vaccine against foot-and-mouth disease virus serotype A in pigs
Published in Antiviral research (01-04-2017)“…Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, and outbreaks of this disease are often economically catastrophic…”
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Modification of the second translation initiation site restricts the replication of foot-and-mouth disease virus in PK-15 cells
Published in Applied microbiology and biotechnology (01-10-2020)“…The translation initiation of foot-and-mouth disease virus (FMDV) occurs at two alternative initiation sites (Lab AUG and Lb AUG). Usually, the Lb AUG is more…”
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11
The rescue and selection of thermally stable type O vaccine candidate strains of foot-and-mouth disease virus
Published in Archives of virology (01-08-2021)“…Inactivated foot-and-mouth disease virus (FMDV) vaccines have been used widely to control foot-and-mouth disease (FMD). However, the virions (146S) of this…”
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12
Evaluation of immunogenicity and cross-reactive responses of vaccines prepared from two chimeric serotype O foot-and-mouth disease viruses in pigs and cattle
Published in Veterinary research (Paris) (08-07-2022)“…Abstract Foot-and-mouth disease (FMD) remains a very serious barrier to agricultural development and the international trade of animals and animal products…”
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Genome-wide analysis of long noncoding RNA profiling in PRRSV-infected PAM cells by RNA sequencing
Published in Scientific reports (10-07-2017)“…Porcine reproductive and respiratory syndrome (PRRS) is a major threat to the global swine industry and causes tremendous economic losses. Its causative agent,…”
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14
Development of a Blocking ELISA Using a Monoclonal Antibody to a Dominant Epitope in Non-Structural Protein 3A of Foot-and-Mouth Disease Virus, as a Matching Test for a Negative-Marker Vaccine
Published in PloS one (20-01-2017)“…Foot-and-mouth disease (FMD) is a devastating animal disease. Strategies for differentiation of infected from vaccinated animals (DIVA) remain very important…”
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15
Prediction and Aerodynamic Analysis of Interior Noise and Wind Drag Generated by the Outside Rear-View Mirror for Commercial Vehicles
Published in Shock and vibration (2020)“…The outside rear-view mirror (OSRVM) is installed on the vehicle’s surface, which causes unwanted aerodynamic noise and wind drag during driving. It is…”
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Development of Foot-and-Mouth Disease Virus-Neutralizing Monoclonal Antibodies Derived From Plasmablasts of Infected Cattle and Their Germline Gene Usage
Published in Frontiers in immunology (06-12-2019)“…Cattle are susceptible to foot-and-mouth disease virus (FMDV), and neutralizing antibodies are critical for protection against FMDV infection in this species…”
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The pH stability of foot-and-mouth disease virus
Published in Virology journal (28-11-2017)“…ᅟ: This review summarized the molecular determinants of the acid stability of FMDV in order to explore the uncoating mechanism of FMDV and improve the acid…”
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Development and Evaluation of a Competitive Enzyme-Linked Immunosorbent Assay Based on Swine Monoclonal Antibodies for Detecting Neutralizing Antibodies against Senecavirus A
Published in Microbiology spectrum (15-06-2023)“…Senecavirus A (SVA) is an emerging viral pathogen related to vesicular disease and neonatal mortality in swine, which results in enormous economic losses to…”
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Identification of the largest non-essential regions of the C-terminal portion in 3A protein of foot-and-mouth disease virus for replication in cell culture
Published in Virology journal (14-09-2020)“…Recent study has shown that the C-terminal portion of 3A (amino acids (aa) 81-153) is not essential for foot-and-mouth disease virus replication in cell…”
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The molecular characteristic analysis of PRRSV GSWW/2015 strain and its pathogenicity to pigs
Published in BMC veterinary research (17-08-2018)“…Porcine reproductive and respiratory syndrome (PRRS) is a severe disease, causing great economic losses to the pig industry. The causative agent, porcine…”
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